Carolinas HealthCare System
In this Section

Physical Medicine and Rehabilitation

Research Summary

Research is one of the three core missions of Carolinas HealthCare System, along with patient care and education.  Carolinas Rehabilitation, a part of Carolinas HealthCare System, is actively involved in research and industry-sponsored clinical trials.  The research faculty and staff in the Department of Physical Medicine and Rehabilitation at Carolinas Rehabilitation are nationally and internationally recognized for their scholarship, innovations, and productivity. Research is focused on advancing the field and providing recovery enhancement for persons with traumatic and acquired brain injury, spinal cord injury, stroke, neuromuscular and degenerative disorders, and other disorders resulting in disability.  Carolinas Rehabilitation has also led the community, state, and region in providing supportive services and opportunities for community-dwelling persons with disabilities.  Researchers have received federal and state funding to develop and apply methodologies and innovative treatment interventions that translate into state-of-the-science patient care and improved patient outcomes.  Research has been selected to receive funding from the National Institute of Health (NIH), National Institute on Disability and Rehabilitation Research (NIDRR), NC Division of Health and Human Services, and Health Resources and Services Administration (HRSA) as well as from several private foundation and industry sponsors.  The research program is fully integrated into clinical care and resident education.

Mission Statement:  Nationally and internationally recognized researchers, collaborating across fields within the community towards one common goal of providing the best recovery for people with disabilities.

Contact Information

Research Office: 704-355-1525
Deptartmen of Physical Medicine and Rehabilitation: 704-355-9330; 704-355-0709 Fax
1100 Blythe Blvd.
Charlotte, NC 28203
Email

Make a donation

You may make a tax-deductible contribution to the Rehabilitation Research and Education Fund. Donations may be mailed to:

Rehabilitation Research and Education Fund
c/o Carolinas HealthCare Foundation
P.O. Box 32861
Charlotte, NC 28232

For more information, call 704-355-4048 or visit Carolinas HealthCare Foundation.

Read more about:
Research Team List
Key Current and Completed Research Programs
Selected Publications

Physical Medicine and Rehabilitation Research Team

This team represents a wide range of interests and expertise in areas such as pediatrics and adult physical medicine and rehabilitation, health and interpersonal communication research, physical therapy, neurophysiology, biomedical engineering, neuropsychology, molecular/translational, occupational therapy, biostatistics and public health.

William Bockenek, MD, Chief Medical Officer, Spinal Cord Injury and Rehabilitation Research
Janet Niemeier, PhD, ABPP, Research Director
Vu Nguyen, MD, Stroke Research, Vice Chair of Academics
Vish Raj, MD, Vice Chair of Clinical Operations
Lori Grafton, MD, Traumatic Brain Injury Research
Jesse Lieberman, MD, Spinal Cord Injury Research
Latonya Lofton, MD, Spinal Cord Injury Research
Tobias Tsai, MD, Pediatric Rehabilitation Research
Mark Hirsch, PhD, Research Scientist Motor Behavioral Neuroscientist
Mark Newman, PhD, Research Scientist

Tami Guerrier, BS, CBIST, Assistant Research Director
William Clay, Research Manager
Marybeth Whitney, RN, Clinical Trials Manager
Sheri Bartel, MEd, CBIST, Coordinator, TBI Project STAR
Mary Andrews, BS, Research Analyst
Jessica Clark, MS, Community Development Specialist
Denise Consoli, BA, CEAS, Patient and Family Educator
Christine S. Davis, PhD, Adjunct Research Scientist
Rose Griffin, BS, TBI Community Development Specialist
Deanna Hamm, BS, CBIS, Research Analyst
Carla Kingsbury, BS, Research Analyst
Amy Ly, Research Tech I
Tiffini Molesky, BS, TBI Community Development Specialist
Sally Rickard, BS, CBIST, TBI Community Development Specialist
James Norton, PhD, Biostatistician

top

Faculty Research Interests

William Bockenek, MD; Find a Doctor; email
Chairman of Physical Medicine & Rehabilitation, Carolinas Medical Center
Chief Medical Officer, Carolinas Rehabilitation

Areas of Expertise and Interest: spinal cord injury medicine, neuromuscular disease, electrodiagnosis

Dr. Bockenek’s areas of research interests are in primary care for persons with disability, medical education, as well as, persons with spinal cord injury, including neurologic recovery, spasticity and pain management. He is active in clinical research activities related to Spinal Cord Injury.   Dr. Bockenek is involved nationally with the American Board of Physical Medicine and Rehabilitation, the American Paraplegia Society, and the American Academy of Physical Medicine and Rehabilitation.
Return to Research Team List
top

Janet P. Niemeier, PhD; email
Professor, Senior Director of Research
Carolinas Rehabilitation, 1100 Blythe Boulevard
Charlotte, North Carolina 28203
Without Compensation Employee, Salisbury Veteran’s Administration Hospital, 1601 Brenner Avenue, Salisbury, NC

Areas of Expertise and Interest: clinical trials of neurobehavioral and cognitive interventions following brain injury, adjustment to disability for TBI, Stroke, SCI, and neuromuscular disorders; ethnic and gender differences in rehabilitation outcomes, and grief following disability

Dr. Niemeier received her PhD from Virginia Commonwealth University and subsequently did postdoctoral work at University of Virginia.  She completed a fellowship at Drexel University College of Medicine in Executive Leadership in Academic Medicine for Women (ELAM), and is Board Certified in Rehabilitation Psychology.  She joined the Department of Physical Medicine and Rehabilitation at Carolinas Rehabilitation in 2012, where she is currently a Professor and Director of Research.

Dr. Niemeier is a nationally and internationally recognized clinician/researcher. Her work has been externally funded for 15 years by such agencies as NIH, NIDRR, and NARSAD.  Her social-behavioral research projects include a manualized intervention for improving functional status of persons with TBI, a manualized intervention for improving productivity after brain injury, and a visual attention strategy to improve outcomes following brain injury in persons with hemispatial inattention or neglect, The Lighthouse Strategy. More recently she and a cross-field collaborative research team at Carolinas HealthCare System are exploring biomarkers that may help shed light on treatments for persons with disabilities related to SCI and TBI.
Return to Research Team List
top

Vu Nguyen, MD, MBA; Find a Doctor; email
Vice Chair of Academics
PM&R Residency Program Director
Medical Director Stroke Rehabilitation
Medical Director Specialty Clinics
Carolinas Rehabilitation, Sports Medicine and Injury Care

Areas of Expertise and Interest: stroke rehabilitation, medical education, faculty development, quality medicine curriculum

Dr. Nguyen received a Master’s of Business Administration (MBA) from East Carolina University and his medical degree from Michigan State University. He completed his residency at Carolinas Medical Center. 

Dr. Nguyen has been a strong proponent of education and research throughout his career. His presentations and publications span two decades. His previous interests ranged from homelessness to brain injury prevention. Currently, his research focus is on a stroke database study, Hemiplegic Shoulder Pain neuromodulation studies, Spastic Hypertonia botulinum toxin studies, Healthcare Debate studies and Homelessness studies.
Return to Research Team List
top

Vish Raj, MD; Find a Doctor; email
Vice Chair of Clinical Operations, Carolinas Rehabilitation
Associate Medical Director of Carolinas Rehabilitation-Main
Director of Cancer Rehabilitation

Areas of Expertise and Interest:  oncology rehabilitation research

Dr. Raj is director of the cancer rehabilitation program at Carolinas Rehabilitation. His primary areas of interests in research are related to functional outcomes in cancer patients, novel methods to approach cancer fatigue, and the treatment of neurological deficits in brain and spinal tumor patients. Dr. Raj completed his training at the Baylor College of Medicine, where he spent extensive time at the MD Anderson Cancer Center. He remains active in the cancer special interest group of the American Academy of Physical Medicine and Rehabilitation.
Return to Research Team List
top

Lori Grafton, MD; Find a Doctor; email
Director of Brain Injury Rehabilitation at Carolinas Rehabilitation
Director of TBI Fellowship Program

Areas of Expertise and Interest: traumatic brain injury rehabilitation

Dr. Grafton received a bachelor of the arts degree from Goucher College and her medical degree from the University of Rochester School of Medicine.  She attended the Amsterdam International Medical Summer School and completed an internship at the Good Samaritan Hospital.  Her residency, with a role as chief resident, was completed at Sinai Hospital.  She completed a Brain Injury Fellowship at Carolinas Rehabilitation.

In her role as brain injury program director, Dr. Grafton has been involved with program development including CARF preparation, implantation of initial family education, development on educational materials to ease the transition from inpatient to outpatient therapies, and efforts to improve patient safety including restraint reduction. She has been an integral part of the development of evidence-based guidelines for the management of mild TBI throughout Carolinas HealthCare System including the education of the Carolinas Trauma Network in recognizing the importance of this injury and developing a system-wide core of recommendations for testing and follow up.  Dr. Grafton served as site principal investigator (PI) for multiple federally-funded research studies on traumatic brain injury.  She is also a PI on several internal grants studying potential biomarkers for traumatic brain injury.  She has been the PI for the TBI Model Systems grant funded by NIDRR as well as the TBI Model Systems Follow Up Site Grant.  
Return to Research Team List
top

Jesse Lieberman, MD, MSPH; Find a Doctor; email
Attending Physician, Carolinas Rehabilitation, Carolinas Medical Center
Physician, outpatient clinic primarily serving patients with spinal cord injuries

Areas of Expertise and Interest: cardiovascular disease prevention in individuals with chronic spinal cord injuries, primarily through nutrition interventions

Dr. Lieberman received his bachelor’s degree in Zoology from North Carolina State University.  He went on to receive his medical degree from Wake Forest University School of Medicine.  He received a certificate in Internal Medicine from East Carolina University School of Medicine, a certificate in physical medicine and rehabilitation from Carolinas Medical Center/Carolinas Rehabilitation, and a certificate in Spinal Cord Injury Medicine from the University of Pittsburgh Medical Center.  He finished an NIH-sponsored postdoctoral research fellowship at Carolinas Medical Center/Carolinas Rehabilitation in 2012 and finished a Master’s in Public Health degree of the University of North Carolina at Charlotte in 2013.   He is also the recipient of a K-award from the National Institutes of Health. 
Return to Research Team List
top

Latanya Lofton, MD; Find a Doctor; email
Director of Spinal Cord Injury Rehabilitation at Carolinas Rehabilitation
Director Outpatient Prosthetics/Orthotics Program

Area of Expertise and Interest: spinal cord injury rehabilitation

Dr. Lofton earned her bachelor’s degree from Rust College and her medical degree from the University of South Alabama College of Medicine.  Her residency was completed at the University of Arkansas for Medical Sciences and she served as a clinical fellow in spinal cord medicine at the Baylor College of Medicine/University of Texas Health Science Center in Houston. 

Dr. Lofton has been involved in multiple quality improvement projects as well as serves as a strong mentor to residents.  In particular, she has received national attention and provided presentations of her study and work related to risk of intimate partner violence, and prevention of abuse, for persons with disabilities. She is involved in research related to study of spinal cord investigator adherence to published guidelines on conduct and reporting of clinical trials.
Return to Research Team List
top

Tobias Tsai, MD; Find a Doctor; email
Medical Director, Pediatric Rehabilitation, Carolinas Rehabilitation
Clinical Assistant Professor of Physical Medicine & Rehabilitation, Carolinas HealthCare System

Areas of Expertise and Interest:  pediatric rehabilitation

Dr. Tobias Jung Ming Tsai received his bachelor of the arts degree from Harvard College in 2000.  He completed his PhD in 2005 from Johns Hopkins University School of Medicine.  He completed an internship at the University of Rochester in 2006 and completed his residency at University of Cincinnati/ Cincinnati Children’s Hospital Medical Center.  And, finally, he completed his fellowship in 2012 at Johns Hopkins University Kennedy Krieger Institute. 

Dr. Tsai has clinical and research experience in pediatric rehabilitation. His clinical, research and scholarship endeavors are focused on pediatric rehabilitation, traumatic brain injury, and spasticity. Dr. Tsai has presented nationally and internationally on pediatric rehabilitation, spasticity, and myelomeningocele.
Return to Research Team List
top

Mark A. Hirsch, PhD; email
Research Scientist and Faculty in the Department of Physical Medicine and Rehabilitation, Carolinas Rehabilitation
Adjunct Associate Professor, University of North Carolina

Areas of Expertise and Interest: innovation and participatory medicine, including conceptual and empirical studies on spouse and patient-as-partner in delivering health care, shared decision making, and potential barriers to physical activity

Dr. Hirsch undertook a study for his PhD degree to identify variables that predict equilibrium control in Parkinson’s disease and two randomized controlled trials of high intensity training to improve balance and quality of life in patients living with Parkinson’s disease.  In 2012, Dr. Hirsch, together with Dr. Sanjay Iyer, developed RENEW Carolinas Parkinson Disease Initiative to improve the quality of care for people living with Parkinson’s disease.  This led to international collaborations with Dr. Erwin van Wegen and Dr. Samyra Keus.  Dr. Hirsch’s research on traumatic brain injury and Parkinson’s disease has been funded through federal (National Institutes of Health) and foundation grants (Park Foundation). 
Return to Research Team List
top

Mark A. Newman, PhD, MPH; email
Assistant Professor and Research Scientist

Areas of Expertise and Interest: epidemiology, physical activity, skeletal muscle physiology, and aging

Dr. Newman received his Bachelor’s and Master’s degrees from Indiana University of Pennsylvania and his MPH and PhD degrees from the University of Pittsburgh.

His main research interests are examining how injury and illness impact physical function. Past research experience focused on falls prevention and ways to attenuate mobility disability in older adults.  Currently, he is focused on developing rehabilitative interventions that use available technology to assess each individual’s functional abilities, allowing for a more accurate characterization of the patient population.  As injury and illness affect each person differently, a goal of his research is to find more effective ways to tailor rehabilitation plans to meet the specific needs of each individual.
Return to Research Team List
top

Key Current and Completed Research Programs:

top

Physical Medicine and Rehabilitation Research Laboratory

The Physical Medicine and Rehabilitation Research Laboratory focuses on scientific evaluation of innovative therapies furthering knowledge and treatments to enhance participation in the community following neurologic injury.  The laboratory uses rigorous qualitative and quantitative research methods.  Neurophysiologic techniques (e.g., computerized dynamic posturography, balance master, gaitrite portable walkway, body-worn inertial sensors) are used to examine coordination of motor control, epidemiology and pathophysiology with emphasis on Parkinson’s disease, stroke, spinal cord and traumatic brain injury (TBI).  Qualitative techniques (e.g., in-depth interviews, focus groups with patients, care-partners and family members) are used to characterize people-centered care.  Various projects evaluate postural control, gait, balance, falls, along with the implementation and evaluation of complex interventions, including:  

  • Biomarkers that characterize persons with TBI and predict outcomes
  • Neurobehavioral and cognitive participatory research intervention trials post-TBI and poly-trauma
  • Gender differences among individuals with TBI and spinal cord injury (SCI)
  • Healthcare disparities
  • Benefits of and barriers to exercise in Parkinson’s disease and TBI
  • RENEW Carolinas Parkinson Initiative (www.CarolinasHealthCare.org/Renew-Carolinas-Neuroscience)
  • Complementary and alternative medicine (CAM) in TBI/SCI/Stroke
  • Randomized controlled trials of treatments/devices for persons with disabilities due to illness or injury
  • Consultants for use of biometric data (e.g., actigraph)

Key Research Programs
top


Brain Injury

An Acute Neurobehavioral Program for Improving Functional Status after TBI
The purpose of this research is to study the effectiveness of a new intervention for improving behavior and abilities after a traumatic brain injury.  The First Steps Acute Neurobehavioral and Cognitive Intervention (FANCI) is a 10-session intervention that focuses on concerns and challenges of early TBI recovery. The study is funded through the National Institute of Health.
Principal Investigator:  Janet Niemeier, PhD, ABPP

TBI Research Registry
The TBI Research Registry is a confidential database of individuals with TBI.  Researchers at Carolinas Rehabilitation established the registry to learn more about the effects of TBI.  The Registry contains contact and health information used to determine study eligibility and to notify participants of existing or upcoming studies in addition to providing information about community opportunities for individuals with TBI and educational information about TBI. 
Principal Investigator:  Lori Grafton, MD and Janet P. Niemeier, PhD, ABPP

TBI Model Systems
Carolinas Rehabilitation was honored to be selected as a TBI Model System from 1998-2012 by the National Institute of Disability and Rehabilitation Research. Carolinas Rehabilitation is currently a Follow Up site for TBI Model Systems. Carolinas Rehabilitation collects data at five years post injury and every five years after this from consented subjects for the TBI National Data and Statistical Center. This involvement allows access and participation in a national database for the purpose of sharing knowledge about recovery following TBI, long-term problems and TBI-related medical issues.
Principal Investigator:  Lori Grafton, MD, Janet Niemeier, PhD, ABPP

Mild TBI Registry
The Mild Traumatic Brain Injury (mTBI) Registry is funded internally through Carolinas Trauma Network Research Center of Excellence.  The study is collaborative among Carolinas HealthCare System’s departments of Physical Medicine & Rehabilitation, Emergency Medicine, and Trauma.  The purpose of this study is to gather information about the effects of mTBI or concussion and follow the changes in symptoms and health status over time to determine best possible treatment interventions. 
Principal Investigators:  Lori Grafton, MD and Michael Gibbs, MD

Mild TBI Participatory Action Research (PAR) Study
The Mild TBI Participatory Action Research Study is funded internally through Carolinas Trauma Network Research Center of Excellence.  The study is collaborative between Carolinas HealthCare System’s departments of Physical Medicine & Rehabilitation and Emergency Medicine.  The primary purpose of this study is to describe the experience of receiving health information about mild TBI from the perspective of the person with the mild brain injury or their family member.  Another purpose of the study is identifying which types of health information about mild TBI provided to patients by their primary care provider following a mild TBI. 
Principal Investigator:  Mark A. Hirsch, PhD

Characterizing Moderators of Gender Differences in Outcome after Traumatic Brain Injury (TBI)
This study leverages the expertise of a cross-field collaborative research team to explore the complexities that may underline the mixed findings related to hormonal neuroprotection after TBI. The team includes a basic scientist, an OB/GYN physician, an Emergency Medicine physician, an attending physician on the brain injury unit at CR, and a Rehabilitation Psychologist with seven years of experience studying gender differences in outcomes after TBI. We will take blood samples from women, ages 18 – 35, and examine relationships between hormone levels and their recovery.
Principal Investigators: PI: Janet P. Niemeier, PhD, ABPP; Co-PI: Jean-Luc Mougeot, PhD; Co-Investigators: Michael Gibbs, MD; Bradley Hurst, MD; Lori Grafton, MD

A Multi-Center, Parallel-Group, Randomized, Double-Blind, Placebo-Controlled Trial of Amantadine Hydrochloride in the Treatment of Chronic TBI Irritability and Aggression: A Replication Study
Approximately 29 to 71 percent of individuals with traumatic brain injury (TBI) experience the problem of irritability and/or aggression which can interfere with interpersonal interaction, relationships and function. The current medical literature does not support standards or guidelines for the management of TBI irritability or aggression. However, pilot research at Carolinas Rehabilitation has revealed that amantadine may reduce irritability and aggression severity and frequency.
The idea for this treatment came from our clinician and family observations of the drug's effect. Amantadine as a treatment for this problem adds to the traditional approach of managing TBI irritability and aggression. To confirm these pilot findings and learn more about the drug's impact on irritability and aggression, Carolinas Rehabilitation is now leading a multi-center research study on the effect of amantadine for 60 days. This project is funded through a $4.2 million grant from the National Institute on Disability Rehabilitation and Research.  Study enrollment is complete and is currently in the analysis phase. 

Participating Study Sites

  • Carolinas Rehabilitation
  • The Institute for Rehabilitation and Research
  • The Ohio State University
  • University of Washington
  • Spaulding Rehabilitation Hospital
  • Indiana University School of Medicine at the Rehabilitation Hospital of Indiana
  • Columbia University will serve as the Data Coordinating Center

Project Director and Principal Investigator:  Flora Hammond, MD

TBI Practice-Based Evidence
Traumatic Brain Injury Practice-Based Evidence is a study funded by the National Institutes of Health that aims to determine the components of inpatient rehabilitation that have the greatest impact on TBI outcomes. With this knowledge, treatments may be developed, refined and tested, to result in improved outcomes following TBI.

Participating Study Sites

  • Brooke Rehabilitation Hospital
  • Carolinas Rehabilitation
  • LDS Hospital Rehabilitation Center
  • Loma Linda University Rehabilitation Institute
  • Ohio Regional TBIMS at The Ohio State University
  • Montreal Rehabilitation Institute
  • Mount Sinai Medical Center
  • National Rehabilitation Hospital
  • Rush University Medical Center
  • Shepherd Center
  • Toronto Rehabilitation Institute

Principal Investigator: Flora Hammond, MD

Traumatic Brain Injury Project STAR
TBI Project STAR is a state-funded, community-based demonstration program that serves individuals affected by TBI by providing information about brain injury, linking to community resources and opportunities, offering educational training and community program development. The program works to facilitate involvement of individuals with TBI in their communities, through referral programs and community program development.
In this study, pertinent information from individuals and families affected by TBI and service providers is collected through focus groups and surveys. Issues studied include barriers to community participation, sports concussion awareness, community opportunities utilized, substance abuse following TBI and use of state-funded services. Researchers analyze results from these to develop a better understanding of how state-provided services and community agency collaborations can meet the needs of individuals
with TBI.
Principal Investigator: Sheri Bartel, MS

Mecklenburg County ABC Board Grant
This award is for modifying and testing a 12-step program for persons with traumatic brain injury to help them access meaningful substance abuse recovery resources. 
Principal Investigators: Sheri Bartel, MS; Rose Griffin, MS; Janet P. Niemeier, PhD, ABPP

Key Research Programs
top

Spinal Cord Injury

Spinal Cord Injury (SCI) Research Registry
The SCI Research Registry is a confidential database of individuals with spinal cord injury.  Researchers at Carolinas Rehabilitation established the registry to learn more about the effects of SCI.  The registry contains contact and health information used to determine study eligibility and to notify participants of existing or upcoming studies in addition to providing information about community opportunities for individuals
Principal Investigator:  Jesse Lieberman, MD

Improving SCI Rehabilitation Outcomes
This a multi-center collaborative project is sponsored by the US Department of Education, National Institute of Disability and Rehabilitation Research.  The goal of the research is to examine, in detail, the individual steps taken in the treatment of individuals with SCI and explore how the method, order or combination of treatment determines the outcome.  The aim is to produce clinical practice improvement and thus improve spinal cord injury patient outcomes.
Principal Investigator:  Flora Hammond, MD 

Key Research Programs
top

Stroke

Stroke Rehabilitation Outcomes Evaluation
This study is a collaborative effort between Carolinas Rehabilitation and Duke University.  The study represents a critical need in stroke rehabilitation research as it will provide a more complete understanding of the patient determinants of meaningful outcomes among individuals following a stroke diagnosis.  This is a retrospective study.
Principal Investigator:  Vu Nguyen, MD and George Thomas, MD

Key Research Programs
top

Neuromuscular Disorders

Exercise and Parkinson’s Disease
This research examines gait, balance and motor coordination among early diagnosed individuals with Parkinson’s disease, the patient “experience” during exercise and the implementation and evaluation of community-based interventions in Parkinson’s disease.
Principal Investigators: Mark A. Hirsch, PhD; Mohammed Sanjak, PhD, PT, MBA; Priscilla Russo; Danielle Englert, MD; Sanjay Iyer, MD; Margaret Quinlan, PhD

Key Research Programs
top

 

Industry-Sponsored Trials
Acute Spinal Cord Injury
Asubio   A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects with Acute Spinal Cord Injury
To evaluate the efficacy of SUN13837 injection versus placebo in acute spinal cord injury (AQSCI) by assessment of motor function using the Total Motor Score (TMS) of the International Standards for Neurological Classification of Spinal Cord Injury (ISNSCI).
PI:  William Bockenek, MD in collaboration with trauma services and Physical Therapy, CMC and CR.

Acorda Therapeutics, Inc

Department of Defense

 

A Double-Blind, Placebo-Controlled Study of AC105 in Patients with Acute Traumatic Spinal Cord Injury
Anticipated neuroprotective agent to be administered within 12 hours of ASCI. Safety and tolerability and effectiveness will be evaluated.
PI: William Bockenek, MD in collaboration with trauma services

InVivo Therapeutics   Pilot Study of Clinical Safety and Feasibility of the PLGA Poly-L-Lysine Scaffold for the treatment of Complete (ASIA A) Traumatic Acute Spinal Cord Injury
This is a first in human early feasibility study to evaluate whether the Scaffold is safe and feasible for the treatment of complete functional spinal cord injury.
PI: William Bockenek, MD; Co-PI: Domagoj Coric, MD
Spinal Cord Injury
Synapse Biomedical   NeuRx Diaphragm Pacing System Humanitarian Use Device
Implanted pocket sized ventilator for high level spinal cord injured persons who are unable to breathe on their own; improving Quality of Life
PI: William Bockenek, MD in collaboration with trauma, and   pulmonary services
Post-Stroke Should Pain
SPR Therapeutics, LLC   A Prospective Multi-Center Study of the SPR System for the Treatment of Post-Stroke Shoulder Pain
To gather preliminary data on the safety and clinical efficacy, and performance of the SPS System for the treatment of Post-stroke Shoulder Pain 
PI: Vu Q.C. Nguyen, MD
Post-Stroke Spasticity
Allergan LTD   Botox® Treatment in Adults with Post-Stroke Lower Limb Spasticity
Evaluating the safety and effectiveness of botulinum Toxin Type A, in a lower extremity
PI: Vu Nguyen, MD

Key Research Programs
top

 

Selected Publications

Bockenek WL, Massagli TL, Swing SR, Fischer C. The development of the physical medicine and rehabilitation milestones. J Grad Med Educ. 2014;6:204-6. PMID: 24701283

Hirsch MA, Sanjak M, Englert D, Iyer S, Quinlan MM. Parkinson patients as partners in care. Parkinsonism Relat Disord. 2014;20 Suppl 1:S174-9. PMID: 24262175

Hirsch MA, Williams K, Norton J, Hammond FM. Reliability of the timed 10-meter walk test during inpatient rehabilitation in ambulatory adults with traumatic brain injury. Brain Injury. 2014;28(8):1115-1120. Doi: 10.3109/02699052.2014.910701

Lieberman JA, Bockenek WL, Stendig-Lindberg G. Therapeutic Exercise. Medscape Reference. Updated March 21, 2014. Available at: http://emedicine.medscape.com/article/324583-overview

Lieberman JA, Goff DC Jr, Hammond FM, Schreiner PJ, Norton HJ, Dulin MF, Zhou X, Steffen LM. Dietary Intake and Adherence to the 2010 Dietary Guidelines for Americans Among Individuals with Chronic Spinal Cord Injury. J Spinal Cord Med. 2014 Jan 3. PMID: 24621049

Lieberman JA, Goff DC Jr , Hammond FM, Schreiner PJ, Norton HJ, Dulin MF, Zhou X, Steffen LM. Dietary Intake Relative to Cardiovascular Disease Risk Factors in Individuals with Chronic Spinal Cord Injury. Top Spinal Cord Inj Rehabil. 2014; 20:127-36. DOI: 10.1310/sci2002-127

Nguyen VQC, Bock WC, Groves CC, Whitney M, Lechman T, Bennett M, Chae J.  Fully Implantable Peripheral Nerve Stimulation for the Treatment of Hemiplegic Shoulder Pain:  A Case Series. Amer J Phys Med Rehab. 2014.

Niemeier JP, Perrin PB, Holcomb MG, Rolston CD, Artman LK, Lu J, Nersessova KS. Gender differences in awareness and outcomes during acute traumatic brain injury recovery. J Womens Health (Larchmt). 2014;23:573-80. PMID: 24932911

Ottens AK, Stafflinger JE, Griffin HE, Kunz RD, Cifu DX, Niemeier JP. Post-acute brain injury urinary signature: a new resource for molecular diagnostics. J Neurotrauma. 2014;31:782-8. PMID: 24372380

Perrin PB, Niemeier JP, Mougeot JL, Vannoy CH, Hirsch MA, Watts JA, Rossman W, Grafton LM, Guerrier TD, Pershad R, Kingsbury CA, Bartel SW, Whitney MP. Measures of Injury Severity and Prediction of Acute Traumatic Brain Injury Outcomes. J Head Trauma Rehabil. 2014. PMID: 24590151

Sanjak M, Hirsch MA, Bravver EK, Bockenek WL, Norton HJ, Rix Brooks B. Vestibular Deficits Leading to Disequilibrium and Falls in Ambulatory Amyotrophic Lateral Sclerosis. Arch Phys Med Rehabil. 2014. PMID: 24946083

van Wegen EEH, Hirsch MA, Huiskamp M, Kwakkel G.  Harnessing cueing training for neuroplasticity in Parkinson’s disease.  Topics in Geriatric Rehabilitation.  2014;30(1):46-57. Doi: 10.1097/TGR.0000000000000005

Brooks BR, Lucas NM, Bravver EK, Story JS, Smith NP, Nichols MS, Belcher SL, Wright KA, Ward AL,Langford VL, Holsten SE, Lindblom SS, PacIcco TJ, Bockenek WL, Sanjak MS, Walgren KL,. Frumkin,LH, Fischer MP, Corey QD, Oplinger HL. Disease-Specific Care (DSC) Certification in Amyotrophic Lateral Sclerosis (ALS) through the Joint Commission (TJC) Audit Protocol - Adding New Performance Measures (PMs) To Improve Patient Outcomes. Annals of Neurology Suppl, 2013: T2422.

Hammond FM, Lieberman J, Smout RJ, Horn SD, Dijkers MP, Backus D. Missed therapy time during inpatient rehabilitation for spinal cord injury. Arch Phys Med Rehabil. 2013;94:S106-14. PMID: 23527767

Lu J, Roe C, Aas E, Lapane KL, Niemeier J, Arango-Lasprilla JC, Andelic N. Traumatic brain injury: methodological approaches to estimate health and economic outcomes. J Neurotrauma. 2013;30:1925-33. PMID: 23879599

Maxwell AMW, Nguyen VQC. Management of Hemiplegic Shoulder Pain.  Curr Phys Med Rehabil Rep. 2013;1(1);1-8. DOI: 10.1007/s40141-0012-0001-y

Niemeier JP, Perrin PB, Holcomb MG, Nersessova KS, Rolston CD. Factor structure, reliability, and validity of the Frontal Systems Behavior Scale (FrSBe) in an acute traumatic brain injury population. Rehabil Psychol. 2013;58:51-63. PMID: 23438000

Raj VS, Lofton L. Rehabilitation and treatment of spinal cord tumors. J Spinal Cord Med. 2013;36:4-11. PMID: 23433329

Rejeski WJ, Axtell R, Fielding R, Katula J, King AC, Manini TM, Marsh AP, Pahor M, Rego A, Tudor-Locke C, Newman M, Walkup MP, Miller ME, Group LSI. Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity Intervention. Clin Interv Aging. 2013;8:1119-31. PMID: 24049442

Tsai TJ, Michaud LM. Visual Vignette: Split Cord Malformation. Am J Phys Med Rehabil. 2013;92(9):839. Doi:10.1097/PHM.0b013e3182328440

Link JN, Kropf M, Hirsch MA, Hammond FM, Karlawish J, Schur L, Kruse D, Davis C. Voting competency and political knowledge: Comparing traumatic brain injury survivors and average college students. Election Law Journal. 2012;11(1), 52-69. DOI: 10.1089/elj.2011.0121

Lieberman JA, Hammond FM, Barringer TA, Goff DC, Jr., Norton HJ, Bockenek WL, Scelza WM. Adherence with the National Cholesterol Education Program guidelines in men with chronic spinal cord injury. J Spinal Cord Med. 2011;34:28-34. PMID: 21528624

Lieberman JA, Hammond FM, Barringer TA, Norton HJ, Goff DC, Jr., Bockenek WL, Scelza WM. Comparison of coronary artery calcification scores and National Cholesterol Education program guidelines for coronary heart disease risk assessment and treatment paradigms in individuals with chronic traumatic spinal cord injury. J Spinal Cord Med. 2011;34:233-40. PMID: 21675362

Nguyen VQC, Harvey RL. Stroke Rehabilitation Process Improvement Project. American Academy of Physical Medicine and Rehabilitation.  http://me.e-aapmr.org/moc4.aspx.  March 2011.

Nguyen VQ, Hirsch MA. Use of a policy debate to teach residents about health care reform. J Grad Med Educ. 2011;3:376-8. PMID: 22942966

Santanasto AJ, Glynn NW, Newman MA, Taylor CA, Brooks MM, Goodpaster BH, Newman AB. Impact of weight loss on physical function with changes in strength, muscle mass, and muscle fat infiltration in overweight to moderately obese older adults: a randomized clinical trial. J Obes. 2011;2011. PMID: 20953373

Newman MA, Pettee KK, Storti KL, Richardson CR, Kuller LH, Kriska AM. Monthly variation in physical activity levels in postmenopausal women. Med Sci Sports Exerc. 2009;41:322-7. PMID: 19127194

Raj VS, Rintala DH. Perceived preparedness for physiatric specialization and future career goals of graduating postgraduate year IV residents during the 2004-2005 academic year. Am J Phys Med Rehabil. 2007;86:1001-6. PMID: 18090441

Lofton LD, Means KM.  Opportunities for Falls Prevention Screening Among Geriatric Outpatients.  Gerontologist.  2006.

Tsai T, Bookstein FL, Levey E, Kinsman SL. Chiari-II malformation: a biometric analysis. Eur J Pediatr Surg. 2002;12 Suppl 1:S12-8. PMID: 12541208

Niemeier JP, Burnett DM. No such thing as 'uncomplicated bereavement' for patients in rehabilitation. Disabil Rehabil. 2001;23:645-53. PMID: 11720114

Niemeier JP, Cifu DX, Kishore R. The lighthouse strategy: Improving the functional status of patients with unilateral neglect after stroke and brain injury using a visual imagery intervention. Top Stroke Rehabil. 2001;8:10-8. PMID: 14523742

Stempien L, Tsai T. Intrathecal baclofen pump use for spasticity: a clinical survey. Am J Phys Med Rehabil. 2000;79:536-41. PMID: 11083304

Niemeier JP. The Lighthouse Strategy: use of a visual imagery technique to treat visual inattention in stroke patients. Brain Inj. 1998;12:399-406. PMID: 9591143

top

 

About Carolinas HealthCare System
Who We Are
Leadership
Community Benefit
Corporate Financial Information
Diversity & Inclusion
Annual Report
Foundation
Patient Links
Pay Your Bill
Hospital Pre-Registration
Patient Rights
Privacy
Financial Assistance
Quality & Value Reports
Insurance
Careers
Join Carolinas HealthCare System
Physician Careers

For Employees
Carolinas Connect
Connect with Us
Watch Carolinas HealthCare on YoutubeFollow Carolinas HealthCare on TwitterLike Carolinas HealthCare on FacebookContact Carolinas HealthCareJoin Carolinas HealthCare on LinkedInGo to our mobile website.