Nephropathy is damage, disease, or other problems with the kidney. IgA nephropathy is a kidney disorder in which antibodies called IgA build up in kidney tissue.
It is also called Berger's disease.
Nephropathy - IgA; Berger's disease
Causes, incidence, and risk factors
IgA is a protein called an antibody that helps the body fight infections. IgA nephropathy (Berger's disease) occurs when too much of this protein is deposited in the kidneys. IgA builds up inside the small blood vessels of the kidney. Structures in the kidney called glomeruli become inflamed and damaged.
IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis.
The disorder can appear suddenly (acute), or get worse slowly over many years (chronic glomerulonephritis).
Risk factors include:
A personal or family history of IgA nephropathy or Henoch Schonlein purpura, a form of vasculitis that affects many parts of the body
Caucasian or Asian ethnicity
IgA nephropathy can occur in people of all ages, but it most often affects males in their teens to late 30s.
There may be no symptoms for many years.
Bloody urine that starts during or soon after a respiratory infection
You may get medicines to control high blood pressure and swelling (edema), such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). Controlling blood pressure is the most important way to delay kidney damage.
Corticosteroids, other drugs that suppress the immune system, and fish oil have also been used to treat this disorder.
Salt and fluids may be restricted to control swelling. A low to moderate protein diet may be recommended in some cases.
Some people will need to take medicines to lower their cholesterol.
Eventually, many patients must be treated for chronic kidney disease and may need dialysis.
For additional information and support, see the IgA Nephropathy Support Network website (www.igansupport.org).
IgA nephropathy gets worse slowly. In many cases, it does not get worse at all. Your condition is more likely to get worse if you have:
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Herbert Y Lin, MD, PhD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.