Carolinas HealthCare System

Yubo Sun, PhD
Senior Scientist, Orthopedic Research Biology
Department of Orthopedic Surgery
Adjunct Associate Professor, University of North Carolina at Charlotte

Prior Positions and Experience

2006-present Senior Scientist, Orthopedic Research Lab, Department of Orthopedic Surgery, Carolinas Medical Center
2001-06 Assistant Professor, Department of Medicine, University of Miami School of Medicine, Miami
1999-2001 Instructor, Department of Medicine, University of Miami School of Medicine, Miami
1997-99 Senior Postdoctoral Fellow, Department of Medicine, University of Miami School of Medicine, Miami
1995-97 Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami
1993-95 Postdoctoral Fellow, Department of Immunology and Microbiology, University of North Texas Health Science Center, Fort Worth


PhD: 1993, The American University (Washington, D.C.)
MS: 1985, Nankai University (Tianjin, China)
BS: 1982, Nankai University (Tianjin, China)

Research Interests

Dr. Sun’s main research interest is to determine the pathogenesis of articular cartilage degeneration and meniscus degeneration. He has authored 41 peer-reviewed scientific articles including invited review articles. He uses a human cartilage/meniscus/synovium explant culture model and several molecular probes to 1) investigate the cellular and gene expression alterations occurring in tissues and cells derived from patients with osteoarthritis, and 2) identify potential therapeutic targets for intervention. Another research interest is to develop small molecule drugs and investigate their disease-modifying activity using animal models of osteoarthritis.

Recent Publications

Sun Y, Mauerhan DR, AM Franklin, Norton HJ, Hanley EN, Jr, Gruber HE. Phosphocitrate is potentially a disease-modifying drug for non-crystal-associated osteoarthritis. BioMed Research International. 2013:326267. [PMID:23555081]

Sun Y, Roberts A, Mauerhan DR, Sun AR, Norton HJ, Hanley EN, Jr. Biological activities of phosphocitrate – a potential meniscal protective agent. BioMed Research International. 2013: 726581. [PMID:23936839]

Sun Y, Mauerhan DR: Meniscal calcification, pathogenesis and implications.  Curr Opin Rheumatol 2012: 24(2):152-7. [PMID:22227878]

Sun Y, Mauerhan DR, Kneisl JS, Norton HJ, Zinchenko N, Ingram J, Hanley EN, Jr, Gruber HE. Histological Examination of Collagen and Proteoglycan Changes in Osteoarthritic Menisci. The Open Rheumatology Journal  2012: 6:29-37. [PMID:22550551]

Current, Recent and Pending Grant Support

Grant Title: Chitasan-PC therapies for degenerative joints diseases and osteochondral defect repair
Funding Agency: Charlotte Health Science Service Foundation
Role: Principal Investigator
Years: 2012-2014

Grant Title: Develop Disease Modifying Drugs and Identify Key Disease Candidate Genes of Osteoarthritis
Funding Agency: NC-Biotech Center
Role: Principal Investigator
Years: 2010-2013