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Toan Huynh

Toan Huynh, MD

Toan Huynh, MD

Director for Trauma Research
The Department of General Surgery
Division of Trauma, Surgical Critical Care and Acute Care Surgery
Adjunct Associate Professor of Biology, University of North Carolina at Charlotte
Clinical Associate Professor of Surgery, University of North Carolina at Chapel Hill

Prior Positions and Experience

Director, Surgical Intensive Care Unit, Carolinas Medical Center

Fellow, Trauma/Critical Care, University of North Carolina at Chapel Hill (Chapel Hill, NC)

Fellow, NIH-NRSA, University of North Carolina at Chapel Hill (Chapel Hill, NC)

Resident, General Surgery, University of North Carolina at Chapel Hill (Chapel Hill, NC)


MD: 1990,University of Washington (Seattle, WA)
BS: 1986, Microbiology and Immunology, University of Washington (Seattle, WA)

Recent Interests

The F.H. “Sammy” Ross Jr. Trauma Center’s laboratory for basic and clinical sciences focuses on studying the effects of systemic inflammation on microcirculation after injuries. Current research projects include the mechanisms of hepatic microcirculatory alterations after trauma and sepsis and the heterogeneity of liver blood flow after systemic stress. These experimental studies examine the pattern of gene expression, organ blood flow at the microcirculatory levels and oxygen transport in the liver. Dr. Huynh continues ongoing collaborations with Mark Clemens, PhD, in the Department of Biology, and Min Shin, PhD, in the Department of Computer Science at the University of North Carolina at Charlotte. Using sophisticated assays for gene analyses, intravital video microscopy and complex computational methodologies, these investigators have gained further insight into the alteration of blood flow patterns during systemic stress. On-going clinical trials examine the therapeutic benefits of chemotherapeutic agents for traumatic brain injuries; as well as the efficacy of new technologies in the operative interventions after severe torso injuries. These research efforts have generated extramural and intramural funding.

Recent Publications

T Huynh, N Nguyen, S Keller, C Moore, M Shin, IH McKillop. Leukocyte Trafficking Preserves Hepatic Function after Sepsis. J Trauma 2010;69(2)360-367. DOI: 10.1097/TA.0b013e3181e65133.

T Huynh, A Blackburn, D McMiddleton-Nyatui, K Moran, MH Thomason, DG Jacobs. An Initiative by Mid-level Providers to Conduct Tertiary Survey at a Level-I Trauma Center. J Trauma 2010;68:1052-1058. DOI: 10.1097/TA.0b013e3181d87789.

Soo-Yeon Ji, R Smith, T Huynh, K Najarian. A Comparative Analysis of Multi-level Computer-assist Decision Making Systems for Traumatic Injuries. BMC Med Info Decision Making 2009;9:2. DOI:10.1186/1472-6947-9-2.

SJ Schmugge, S Keller, N Nguyen, R Souvenir, T Huynh, MG Clemens, MC Shin. Segmentation of Vessels Clustered with Cells Using a Physics Based Model. Medical Image Computing and Computer Assisted Intervention, Lecture Notes in Computer Science 2008;5241:127-134 [PMID: 18979740]

T Huynh, K Moran, A Blackburn, DG Jacobs, MH Thomason, RF Sing. Optimal Management Strategy for Incidental Findings in Trauma Patients: An Initiative for Mid-level Providers. J Trauma 2008;65:331-336 [PMID: 18695467]

Jacobs DG, Sarafin JL, Huynh T, Miles WS, Sing RF, Thomason MH. Audience response system technology improves accuracy and reliability of trauma outcome judgments. J Trauma 2006; 61: 135-143. [PMID: 16832261]

Huynh T, Jacobs DG, Dix S, Sing RF, Miles WS, Thomason MH. Utility of neurosurgical consultation for mild traumatic brain injury. Am Surg 2006; 72: 1162-1167. [PMID: 17216813]

Kamoun WS, Shin MC, Keller S, Karaa A, Huynh T, Clemens MG. Induction of biphasic changes in perfusion heterogeneity of rat liver after sequential stress in vivo. Shock 2005; 24: 324-331. [PMID: 16205316]

Burns JM, Sing RF, Mostafa G, Huynh T, Jacobs DG, Miles WS, Thomason MH. The role of transesophageal echocardiography in optimizing resuscitation in acutely injured patients. J Trauma 2005; 59: 36-42. [PMID: 16096536]

Paxian M, Keller SA, Baveja R, Korneszczuk K, Huynh T, Clemens MG. Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver. Microcirculation 2004; 11: 435-449. [PMID: 15280069]

Current, Recent and Pending Grant Support

Grant Title: Information Integration and Processing for Computer Aided Trauma Decision Making
Funding Agency: National Science Foundation
Role: Co-Principal Investigator
Years: 2007-2010

Grant Title: Role of micro-RNA in hepatic microcirculatory failure during sepsis
Funding Agency: Carolinas HealthCare System - Education & Research Foundation
Principal Investigator: Cathy Moore, PhD, Post-doctoral Fellow
Co-Principal Investigator:Toan Huynh, MD

Grant Title: Hepatic Microcirculatory Dysfunction after Trauma and Sepsis
Funding Agency: American Association for the Surgery of Trauma
Role: Principal Investigator
Years: 2003-2006

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