Research Technician II
Prior Positions and Experience
MS in Molecular Cell Biology; 2006-2007 Uppsala University, Sweden
Marjan Mohseni has been working in the field of viral hepatitis for seven years. She joined in the Liver Group of the Research Center for Gastroenterology and Liver Diseases in Tehran, Iran, in 2002 working under the supervision of Professor Mohammad R. Zali. While in this lab, she worked on the molecular epidemiology of viral hepatitis.
Her collaboration with the Swedish Institute for Infectious Diseases Control led Marjan to carry on her research under the supervision of Professor Lars Magnius in late 2003. Marjan examined the molecular epidemiology of hepatitis B and assisted in the identification of a novel core promoter mutation in HBV isolates of Hepatitis B patients that was published in journal of General Virology. Marjan also worked on the molecular epidemiology of viral hepatitis A, C, and E while in Sweden as well as the complete genome sequencing of Enterovirus strains in a European multi-country project called Vizier.
Marjan's master thesis project involved the epigenetic reprogramming of host by CMV. She assisted in a collaborative project under supervision of Professor Tomas Ekstrom to identify DNMT1 translocation out of the cell by CMV transfection.
Since 2008, Marjan joined Liver, Digestive and Metabolic Disorders Laboratory when she explored the effects of a natural compound from Milk Thistle, Legalon-Sil on HCV replication under the guidance of Dr. Herbert Bonkovsky. Currently, Marjan is working in Liver Pathobiology Laboratory under the supervision of Dr. Laura Schrum, PhD, on identifying effects of Legalon-Sil on HCV entry into hepatocytes.
Sendi H, Mehrab-Mohseni M. HFE Gene Mutations in Cryptogenic Cirrhosis Patients. Hepat Mon. 2012;12:48-9. [PMC: 3298877]
Esteki-Zadeh A, Karimi M, Strååt K, Ammerpohl O, Zeitelhofer M, Jagodic M, Mehrab-Mohseni M, Sjöholm L, Rahbar A, Söderberg-Nauclér C, Ekström TJ. Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity. Epigenetics. 2012 Jun 1;7(6):585-93. [PMID: 22595877]
Mehrab-Mohseni M, Sendi H, Steuerwald N, Ghosh S, Schrum LW, Bonkovsky HL.Legalon-SIL down regulates HCV core and NS5A in human hepatocytes expressing full-length HCV. World J Gastroenterol. 2011;17:1694-700. [PMID: 21483629]
Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM , Noorinaye B, Zali MR, Pumpens P, Bonkovsky HL, Magnius LO. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low viral load. J Clin Virol 2009; 46:259-264. [PMID: 19748824]
Sendi H, Mehrab-Mohseni M, Zali MR, Norder H, Magnius LO. T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D. J Gen Virol 2005; 86: 2451-8. [PMID: 16099903]
Selected Meeting and Abstract Presentations
Mehrab-Mohseni M, Sendi H, Schrum LW, Bonkovsky HL. Legalon-SIL down-regulates Occludin and Claudin expression in human liver cells expressing full length HCV genome. Hepatology: 54: 817A-817A, Suppl. 1, Oct 2011
Sendi H, Mehrab-Mohseni M, Schrum LW, Bonkovsky HL. Mir-122 down-regulates OCLN expression through direct binding to the 3 ' UTR of OCLN mRNA . Hepatology 54: 1318A-1319A, Suppl. 1, Oct 2011
Mehrab-Mohseni M, Steuerwald N, Sendi H, Vachris J, Bonkovsky HL. Legalon-Sil down-regulates HCV core and NS5A expression in human hepatoma lines expressing full-length HCV. Hepatology 50: 685A-686A, 2009
Sendi H, Mehrab-Mohseni M, Steuerwald N, Bonkovsky HL. Heme Oxygenase 1 [HMOX1] expression is up-regulated by HCV in human hepatoma cells and is normalized through IFN treatment. Hepatology 50: 936A, 2009
Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM , Noorinaye B, Zali MR, Pumpens P, Bonkovsky HL, Magnius LO. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low viral load. Digestive Disease Week. Chicago 2009
Steuerwald N, Bennett K, Mehrab-Mohseni M, Sendi H, Bonkovsy HL. Global miRNA Expression Profile of HCV Infected Human Hepatoma Cells. Digestive Disease Week. Chicago 2009
Karimi M, Mehrab-Mohseni M, Strat K, Soderberg-Naucler C, Ekstrom T. Epigenetic Reprogramming of host by Human Cytomegalovirus. KI Cancer. Stockholm, September 2007
Sendi H, Mehrab-Mohseni M, Zali MR, Norder H, Magnius LO. Mutations in core immune epitopes in different promoter and precore mutants in chronic e antigen negative hepatitis B. J Clinical Virol. 36: S82-S82 Suppl. 2, July 2006