Carolinas HealthCare System

H. James (Jimy) Norton, PhD

H. James (Jim) Norton, PhD
Director of Biostatistics

Prior Positions and Experience

1980-1989                   System Manager, CLINFO Computer Center, Baylor College of Medicine, (Houston)

1978-1980                   NIH  Cardiovascular traineeship, University of Texas (Houston)


PhD:  1989,  University of Texas (Houston)
MS:   1980,  University of Texas  (Houston)
BA:    1970,  University of Connecticut

Statistical analysis of clinical trials, epidemiologic studies,  and medical research, and improving statistical education in the health sciences

Dr. Norton has been Director of Biostatistics at the Carolinas Medical Center since 1990. His work has cut across a number of topics and Departments at CMC. He has analyzed data from clinical trials of sodium bicarbonate to prevent contrast induced nephropathy, amoxicillin prophylaxis for dental procedures, and a non-inferiority trial, once daily versus twice daily amoxicillin for pediatric streptococcal pharyngitis. In emergency medicine, he has analyzed data regarding patient outcomes after implementation of a new stroke protocol, predicting patient outcomes for patients with a pulmonary embolism, and regarding the use of ultra-sound in the emergency department. In the area of cancer, topics for publication have included trends in breast conservation, new staging strategies for Stage III colon and rectal cancer and methods of biopsy for melanoma. In the surgical area, he has helped evaluate patient outcomes following cardiac bypass surgery, trauma surgery and laparoscopic surgery. In the basic sciences, he has co-authored a number of papers concerning disc-degeneration in both humans and the sand rat model. 

In the field of education, he has won several national awards for his presentations on improving statistical education for undergraduate biology students and medical  residents. He was the recipient of the Best Contributed Paper from American Statistical Association Teaching in the Health Sciences Section (2007 and 2009) and Statistical Education Section (2006 and 1998).  He has also received Faculty Teaching Awards from Carolinas Institute for Rehabilitation (2003) and the Dental Residency Program from Carolinas Medical Center (1993). He has written chapters on statistics and epidemiology for a text book for surgical residents reviewing for the American Board of Surgery In-training Examinations. He serves on the editorial board of the Journal of Surgical Oncology. He was a reviewer for the Orthopedic Clinical Trial Peer Review Panel for the Department of Defense. 

Recent Publications

Gruber HE, Ingram JA, Norton HJ, Hanley EN.  Senescence in cells of the aging and  degenerating disc. Spine 2007; 32:  321-327. [PMID:  17268263]

Norton HJ, Divine GW. The Will Rogers Effect. UMAP Journal 2007; 28: 75-85. [Article Overview]

Stell VH, Norton HJ, Smith SS, Salo JC, White RL.  Method of biopsy and incidence of positive margins in primary melanoma.  Ann  Surg Oncol 2007; 14: 893-898. [PMID: 17119869]

Merten GJ,  Burgess WP, Gray LV, Holleman JH, Roush TS, Kowalchuk GJ, Bersin RM, Van Moore  A, Simonton CA 3rd, Rittase RA, Norton HJ, Kennedy TP. Prevention of  contrast-induced nephropathy with sodium bicarbonate: A randomized controlled  trial.  JAMA 2004; 291:  2328-2334. [PMID:  15150204]

Greene FL, Stewart AK, Norton HJ. New tumor-node-metastasis staging strategy for  node-positive (Stage III) rectal cancer: An analysis.  J Clinl  Oncol 2004; 22: 1778-1784. [PMID: 14769855]

Current, Recent and  Pending Grant Support

Grant Title: Post TBI Irritability & Aggression: An evidence-based approach to management
Funding Agency: Department of Education
Role: Biostatistician/Co-investigator
Years: 2007-2012

Grant Title: Carolinas traumatic brain injury and rehabilitation system
Funding Agency: Department of Education
Role: Biostatistician/Co-investigator
Years: 2002-2007

Grant Title: Surrogate markers for severe pulmonary embolism
Funding Agency: NIHLBI
Role: Biostatistician/Co-investigator
Years: 2003-2006