The Department of Internal Medicine has grown dramatically in the last five years, adding 18 new faculty members and a number of new lines of investigation.
|704-355-3165 / 704-355-0709 Fax|
|Scott Furney, MD, FACP, 1100 Blythe Blvd, Charlotte, N.C. 28203|
Make a Donation
You may make a tax-deductible contribution to:
Department of Internal Medicine Research and Education Fund
c/o Carolinas HealthCare Foundation
PO Box 32861
Charlotte, N.C. 28232
For further information, contact 704-355-4048.
Faculty Research Interests
Scott Furney, MD, FACP
Chairman, Department of Internal Medicine
Dr. Furney received his MD from the University of Michigan, and also completed his Internal Medicine training there. His research interests have included faculty development in clinical teaching, quality of health care, and thromboembolism treatment and prevention.
Fletcher KE, Furney SL, Stern DT. Patients speak: what's really important about bedside interactions with physician teams. Teach Learn Med 2007; 19: 120-127. [PMID: 17564539]
Almanaseer Y, Mukherjee D, Kline-Rogers EM, Kesterson SK, Sonnad SS, Rogers B, Smith D, Furney S, Ernst R, McCort J, Eagle KA. Implementation of the ACC/AHA guidelines for preoperative cardiac risk assessment in a general medicine preoperative clinic: improving efficiency and preserving outcomes. Cardiology 2005; 103: 24-29. [PMID: 15528897]
Parekh V, Saint S, Furney S, Kaufman S, McMahon L. What effect does inpatient physician specialty and experience have on clinical outcomes and resource utilization on a general medical service? J Gen Intern Med 2004; 19: 395-401. [PMID: 15109336]
Furney SL, Jensen J, Williams BC. A feasibility study of on-site teacher training for ambulatory preceptors. Med Educ 2001; 35: 1087. [PMID: 11715977]
Furney SL, Orsini AN, Orsetti KE, Stern DT, Gruppen LD, Irby DM. Teaching the one-minute preceptor. A randomized controlled trial. J Gen Intern Med 2001; 16: 620-624. [PMID: 11556943]
Jianfeng Cheng, MD, PhD
Dr. Jianfeng Cheng is a faculty member of the Gastroenterology Division for the department of Internal Medicine. She received her medical degree from Zhejiang Medical University in Zhejiang, China. She has also completed her Masters and PhD in Biostatistics from Columbia University, New York. Dr. Cheng completed her Internal Medicine residency at the New York Medical College, New Rochelle and her GI fellowship from the Virginia Commonwealth University in Richmond. Prior to this she trained extensively in Zhejiang, China.
Dr. Cheng is interested in utilizing a system biology approach to investigate the microbiota in inflammatory bowel disease (IBD), comparing the spectrum between inflammatory bowel disease and general population. She is also looking at the association between infection, thromboembolic disease or coronary artery disease and inflammatory bowel disease. In addition, she is interested in applying Nutraceutical medicine into IBD and optimizing the outcome/ outcome measurement of IBD, issues related to women in IBD; including health maintenance and pregnancy, investigating proactive management vs “crisis” management and implementing an IBD population health management toolkit. Currently she is acting as principal investigator of the following clinical trial: Legacy (P11-282: A Long-Term Non-Interventional Registry to Assess Safety and Effectiveness of HUMIRA® (Adalimumab) in Patients with Moderately to Severely Active Ulcerative Colitis (UC).
Jin P, Cheng J, Liu D, Mei M, Xu Z, Sun L. Endoscopic papillary large balloon dilation versus endoscopic sphincterotomy for retrieval of choledocholithiasis: A meta-analysis. World J Gastroenterol. 2014;20(18):5548-56. PMCID: PMC4017071
Jones R, Scobey M, Cheng J. The Risk of Colon Cancer in Inflammatory Bowel Disease. Journal Medical Sciences Gastrointestinal and digestive system. In press.
Min HK, Sookoian S, Pirola CJ, Cheng J, Mirshahi F, Sanyal AJ. Metabolic profiling reveals that PNPLA3 induces widespread effects on hepatic metabolism beyond triacylglycerol remodeling in HUH-7 hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2014 [Epub ahead of print]. PMID: 24763554
Ye L, Cao Q, Cheng J. Review of Inflammatory Bowel Disease in China. Hindawi Publishing Corporation, The Scientific World Journal: Gastroenterology. Volume 2013, Article ID 296470. Http://dx.doi.org/10.1155/2013/296470
Asgharpour A, Cheng J, Bickston SJ. Adalimumab treatment in Crohn's Disease: an overview of long-term efficacy and safety in light of the EXTEND trial. Clin Exp Gastroenterol. 2013;6: 153–160. PMCID: PMC3770493
Stravitz TR, Sanyal AJ, Reisch J, Bajaj JS, Mirshahi F, Cheng J, Lee WM.3 and the Acute Liver Failure Study Group. Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival. Liver Int. 2013 Oct; 33(9):1324-31. PMID: 23782487
Cheng J, Joyce A, Yates K, Aouizerat B, Sanyal AJ (2012) Metabolomic profiling to identify predictors of response to vitamin E for non-alcoholic steatohepatitis (NASH). PLoS ONE. 2012;7(9): e44106. doi:10.1371/journal.pone.0044106
Tannous MM, Cheng J, Muniyappa K, Farooq I, Bharara A, Kappus M, Luketic V, Stravtiz RT, Fuchs M, Puri P, Sanyal A, Sterling R. Use of tacrolimus in the treatment of autoimmune hepatitis: a single center experience. Aliment Pharmacol Ther. 2011 Aug; 34(3):405-7. PMID: 21726256
Reilly NR, Aguilar K, Hassid BG, Cheng J, Defelice AR, Kazlow P, Bhagat G, Green PH.
Celiac disease in children with normal weight and overweight: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr. 2011 Nov;53(5):528-31. PMID: 21670710
Chang MS, Minaya MT, Cheng J, Connor BA, Lewis SK, Green PH. Double-blind randomized controlled trial of rifaximin for persistent symptoms in patients with celiac disease. Dig Dis Sci. 2011 Oct; 56 (10):2939-46. PMID: 21647654
Sun LM, Shang Y, Zeng YM, Deng YY, Cheng J. HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication. World J Gastroenterol. 2010 Sep 21;16 (35):4476-82. PMID: 20845517
Gonda TA, Khan SU, Cheng J, Lewis SK, Rubin M, Green PH. Association of intussusception and celiac disease in adults. Dig Dis Sci 2010 Oct;55(10):2899-903. PMID: 20033844
Gonzalez S, Gupta A, Cheng J, Tennyson C, Lewis SK, Bhagat G, Green PH. Prospective study of the role of duodenal bulb biopsies in the diagnosis of celiac disease. Gastrointest Endosc. 2010 Oct;72(4):758-65. PMID: 20883853
Cheng J, Brar PS, Lee A, Green PH. Body Mass Index in Celiac Disease: beneficial effect of a gluten-free diet. J Clin Gastroenterol. 2010 Apr;44(4):267-71. PMID: 19779362
Cheng J, Mallahias T, Brar PS, Minaya MT, Green PH. The association between celiac disease,
dental enamel defects and aphthous ulcers in a United States cohort. J Clin Gastroenterol. 2010 Mar;44(3):191-4. PMID: 19687752
Recent Abstracts and Presentations:
Adam J, Bien A, Smallfield G, Kachaamy T,Shah R,Alebouyeh N,Sima A, Cheng J, Zfass A. The Use of Spray Cryotherapy in the Management of Esophageal Carcinoma. Poster presentation. 2014 Digestive Disease Week. Chicago, Illinois. May 3-6, 2014.
Lachar J, Cheng J, Smallfield G. Gastrointestinal Bleeding in Ventricular Assist Device and Total Artificial Heart Implantations. Poster presentation. 2014 Digestive Disease Week. Chicago, Illinois. May 3-6, 2014.
Adam J, Kachaamy T, Cheng J, Puri P. How solid are iron indices for risk stratification in suspected iron deficiency anemia? Poster presentation. 2014 Digestive Disease Week. Chicago, Illinois. May 3-6, 2014.
Cheng J, Proctor P, Maddukuri V, Scobey M. Narcotic Addiction Plus “Ileus” Is Not Always Narcotic Bowel Syndrome: A Case Report. Poster presentation, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s and Colitis Foundation’s Clinical and Research Conference. Hollywood, FL, December 12-14, 2013
Cheng J, Cao Q. Infliximab and Tuberculosis Infection: A Meta-Analysis. Poster presentation, 2013 Advances in Inflammatory Bowel Diseases, Crohn’s and Colitis Foundation’s Clinical and Research Conference. Hollywood, FL, December 12-14, 2013
Cheng J, Kaspar M, Call S, Smallfield G. Unusual Cause of Ascites: a Rare Case Report of Peritoneal Sarcomatous Mesothelioma. Poster presentation. 2013 American College of Gastroenterology 2013 Scientific Meeting. San Diego, October 11-16, 2013.
Cheng J, Bouhaidar D, Chambers K, Willingham R, Zfass A. Cryoablation therapy for Barrett’s Esophagus and Esophageal Cancer: A Single Center Experience. Poster presentation. 2013 American College of Gastroenterology 2013 Scientific Meeting. San Diego, October 11-16, 2013.
Cheng J, Joyce A, Yates K, Sanyal AJ. Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH): what is the mechanism? Poster presentation, 2013 Digestive Disease Week. Orlando, Florida May 18-21, 2013.
Cheng J, Joyce A, Yates K, Sanyal AJ. Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH): what is the mechanism? Oral presentation, 2013 Southern Regional Meetings New Orleans, Feb 21-23, 2013.
Andrew Dries, MD
Dr. Dries has been a member of the Department of Internal Medicine and Division of Gastroenterology since 2007. He received his medical degree from the University of Rochester School of Medicine and Dentistry and completed a residency in Internal Medicine from Vanderbilt University. He then completed a fellowship in Gastroenterology and Therapeutic Endoscopy at Baylor College of Medicine in Houston, TX prior to joining the faculty. He is currently involved with implementation of a 4th year Advanced Endoscopy Gastroenterology Fellowship at Carolinas Medical Center. His current clinical and research interests include advanced endoscopy including ERCP and Endoscopic Ultrasound as well as pancreatic and biliary disorders.
Law JK, Stoita A, Weaver W, Gleeson FC, Dries AM, Blackford A, Kiswani V, Shin EJ, Khashab MA, Canto MI, Singh VK, Lennon AM. Endoscopic ultrasound-guided fine needle aspiration improves the pre-operative diagnostic yield of solid-pseudopapillary neoplasm of the pancreas: an international multicenter case series (with video). Surg Endosc. 2014 April. [Epub ahead of print]. PMID: 24718662
Dries AM, Richardson P, Cavazo J, Abraham NS. Therapeutic intent of proton pump inhibitor prescription among elderly NSAID users. Aliment Phamacol Ther. 2009 Sep 15; 30(6): 652-61. doi: 10.1111/j.1365-2036.2009.04085.x
Sussman NL, Lee PL, Dries AM, Schwartz MR, Barton JC. Multi-organ iron overload in an African American man with ALAS2 and R452S and SLC40A1 R561G Acta Hematol 2008;120:168-173. PMID: 19573167
Dries AM, McDermott J. Diagnosis of Cystic Lymphangioma of the Pancreas with Endoscopic Ultrasound guided Fine Needle Aspiration. Am J Gastroenterol. 2008 Apr;103(4):1049-50. PMID: 18397437
James Horton, MD
Dr. Horton is the Chief of the faculty division for Infectious Disease of the Department of Internal Medicine. He received his medical degree from Duke University in 1977. He completed his Internal medicine residency at University of Florida, Gainesville and his Infectious Disease Fellowship Ochsner Clinic in New Orleans and University of Colorado, Denver.
Dr. Horton has participated as an investigator for HIV clinical trials both for the AIDS Clinical Trials Group and pharmaceutical companies. He has also worked with the CDC on their Tuberculosis clinical trials. His current research interests include the effects of environmental and medical interventions on the indigenous microbiota of the body. He has also teamed with Duke University on a trial looking at the length of IV antibiotic dosing in patients with bacteremia.
Marc Johnson, MD
Dr. Johnson is the Medical Director for the Infectious Disease Clinic at Carolinas Medical Center Myers Park and a member of the faculty Internal Medicine Department. He obtained his Medical Degree from Mt. Sinai College of Medicine, New York in 1985. He completed his residency and internship in Internal Medicine at the Long Island Jewish Medical Center, New Hyde Park, NY.
Dr. Johnson’s research interests include HIV and Hepatitis C treatment options and therapies. Specifically his is interested in the treatment and management of patients who are co-infected with both diseases. He is a participating investigator in more than 15 current and past pharmaceutical trials at Carolinas Medical Center. He is currently the principal investigator for 12 active clinical trials at Myers Park Infectious Disease Clinic. Combined with centers throughout the United States, and often globally, he has contributed patient information and data that led to the approval and use of many current HIV therapy options, including 3 newly approved medications since 2012.
Floris-Moore M, Mollan K, Wilkin A, Johnson M, Kashuba A, Wohl DA, Patterson K, Ragan D, Zelasky C, d Curring D, Pittard D, Eron Jr J. Antiretroviral Activity and Safety of Once-daily Etravirine in Treatment-naïve HIV-infected Adults. Infectious Diseases Society of America. October 8-12, 2013.
Eron Jr j, Rockstroh J, Pozniak A, Elliott J, Small C, Johnson M, Brennan C, Pappa K, Cuffe R, and the SPRING-2 and SINGLE Study Teams. Dolutegravir Treatment Reponses by Baseline Viral Load and BRTI Backbone in Treatment-Naïve, HIV-Infected Individuals. 11th International Congress on Drug Therapy in HIV Infections; November 11-15, 2012; Glasgow, UK.
Laszlo Littmann, MD, PhD
Dr. Littmann received his MD degree in 1970 from the Semmelweis University Medical School in Budapest, Hungary, and a PhD degree in 1983 from the Hungarian Academy of Sciences. He is board certified in Internal Medicine and Cardiology. His main research interests include clinical electrocardiography, clinical electrophysiology, cardiac arrhythmias and heart failure. Dr. Littmann serves as ad hoc reviewer for the following journals: Circulation, Journal of the American College of Cardiology, International Journal of Cardiology, American Journal of Cardiology, Heart, PACE (Pacing and Clinical Electrophysiology), Journal of Electrocardiology, Journal of Cardiovascular Electrophysiology, Lasers in Medical Science, Medical Science Monitor, Medical Principles and Practice and Clinical Cardiology. He has published over 200 publications in peer-reviewed scientific journals and textbooks and over 50 published abstracts. Dr. Littmann's publications have over 900 citations in peer reviewed scientific journals and textbooks.
Ongoing Research Studies
Outcome of patients who were discharged from a heart failure disease management program following full clinical and echocardiographic recovery. This study addresses the issue whether patients with a remote history of severe systolic heart failure can maintain clinical and echocardiographic recovery outside of the setting of intensive disease management.
Medical management, without revascularization, in patients with severe ischemic cardiomyopathy due to inoperable multivessel coronary artery disease. This study will review cases of severe ischemic cardiomyopathy where medical management alone resulted in full clinical and echocardiographic recovery.
The clinical significance of the electrocardiographic “spiked helmet” sign. This study collects clinical cases where the electrocardiogram showed a “spiked pattern” type pseudo-ST elevation. Our preliminary observations suggest that this new ECG sign is associated with critical non-cardiac illness and a high risk of in-hospital death.
The electrocardiogram in severe ascites. This study will systematically evaluate ECG abnormalities associated with large ascites. Our preliminary observations suggest that the ECG of ascites patients frequently resembles the ECG described in massive pulmonary embolism.
The electrocardiogram in late-term pregnancy. This study will systematically evaluate ECG abnormalities seen in late term pregnancy. Our preliminary observations suggest that the ECG of women in late term pregnancy frequently resembles the ECG described in massive pulmonary embolism.
Consistent mistakes by the MUSE 12SL electrocardiogram interpretation software. This study will systematically evaluate the accuracy of two interpretation software ECG diagnoses: that of “sinus tachycardia with first degree AV block” and that of “accelerated junctional rhythm.” Our preliminary observations suggest that these 2 interpretation software diagnoses are frequently incorrect.
Butschek R, Farrell RM, Littmann L. What is the cause of the apparent pacemaker malfunction? J Electrocardiol 2013; 46: 108-9. PMID: 23620875
Sathe NS, Friedman HB, Mehta R, Littmann L. Consult for heart block in a heart transplant recipient. Int J Cardiol 2013; 165: e30-e32. PMID: 23164589
Littmann L, Butschek R, Okeagu E. Rapid repetitive electric signals in a 12-lead ECG and in telemetry. J Electrocardiol 2013; 46: 366-7. PMID: 23980255
Littmann L, Monroe MH. Tombstone ST elevation without myocardial infarction: a variant of the “spiked helmet” sign? Am J Med 2013; 126: e9-e10. PMID: 23885687
Littmann L, Narveson SY, Fesel NM, Marconi SL. Beta blocker treatment of heart failure patients with ongoing cocaine use. Int J Cardiol 2013; 168: 2919-20. PMID: 23664043
Butschek R, Powell BD, Littmann L. Phase 4 paroxysmal AV block in a patient with scleroderma. J Electrocardiol 2013; 46: 679-81. PMID: 23849957
Littmann L, Bustin DJ, Haley MW. A simplified and structured teaching tool for the evaluation and management of pulseless electrical activity. Med Princ Pract 2014; 23: 1-6. PMID: 23949188
Siewe D, Nichols KB, Furney SL, Littmann L. King of hearts for ace of spades: apical hypertrophic cardiomyopathy. Am J Med 2014; 127: 31-3. PMID: 24239440
Littmann L. Electrocardiographic STEMI: a common but nonspecific finding in the ICU. Am J Med 2014; 127: e17-e18. PMID: 24462017
Littmann L. Wide QRS complex rhythm with pulseless electrical activity. Cleve Clin J Med 2014; 81: 81-82. Doi: 10.3949/ccjm.81a.13079
Littmann L, Proctor P. Real time recognition of the electrocardiographic “spiked helmet” sign in a patient with pneumothorax. Int J Cardiol 2014; 173: e51-e52. PMID: 24698249
Mark, Russo, MD, MPH, FACG, AGAF
Dr. Russo is Chief, Division of Hepatology and Medical Director of Liver Transplantation at Carolinas Medical Center. He received his medical degree at the Mount Sinai School of Medicine, NY and completed his internal medicine residency, gastroenterology, transplant hepatology and epidemiology fellowship at The University of North Carolina School of Medicine and Public Health. His current clinical interests are in cirrhosis, viral hepatitis, hepatocellular carcinoma and autoimmune liver diseases. His research interests are in cirrhosis, hepatocellular carcinoma and drug induced liver injury. He has more than 80 peer-reviewed publications and 10 book chapters. He serves on national committees for the American College of Gastroenterology and American Association for the Study of Liver Diseases. He has more than 60 presentations at national meetings. He is the recipient of grants from the National Institutes of Health-NIDDK, American College of Radiology Institutional Network, and American College of Gastroenterology. He is board certified in Internal Medicine, Gastroenterology and Transplant Hepatology.
Recent publications or book chapters:
Russo MW, Hoofnagle J, Gu J, Fontana RJ, Barnhart H, Kleiner DE, Chalasani N, Bonkovsky HL. The spectrum of statin hepatotoxicity: experience of the Drug Induced Liver Injury Network. Hepatology. 2014 April 2. [Epub ahead of print]. PMID: 24700436
Russo MW, Narang T, Eskind L, Hayes D, Casingal V, Purdum PP, Hanson JS, Ahrens W, Norton J, Bonkovsky H. Intravenous interferon administered during liver transplantation is not effective in preventing hepatitis C reinfection. Dig Dis Sci. 2013;58(10):3010-6. PMID 23812862
Yazici C, Niemeyer D, Iannitti DA, Russo MW. Hepatocellular carcinoma and cholangiocarcinoma, an update. Expert Rev Gastroenterol Hepatol 2014 Jan;8(1):63-82. PMID 24245910
Wald C, Russo MW, Heimbach JK, Hussain HK, Pomfret EA, Bruix J. New OPTN/UNOS policy for liver transplant allocation: standardization of liver imaging, diagnosis, classification and reporting of hepatocellular carcinoma. Radiology. 2013;266(2):376-382. PMID: 23362092. DOI: 10.1148/radiol.12121698
Maddukuri VC, Russo MW Ahrens WA Emerson SU, Engle RE, Purcell RH, Thompson EB, Bonkovsky HL. Chronic hepatitis E with neurologic manifestations and rapid progression of liver fibrosis in a liver transplant recipient. Dig Dis Sci. 2013;58(8):2413-6. PMID 23512404
Lakner A, Steuerwald N, Walling TL, Ghosh S, Li T, Mckillop IH, Russo MW. Bonkovsky H, Schrum LW. Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology. 2012 Jan 25; 56(1):300-10. PMID:22278637
Russo MW. Hepatocellular Carcinoma and Cholangiocarcinoma. In:Common Liver Diseases and Transplantation An Algorithmic Approach to Work-Up and Management, ed. Brown Jr RS. Slack Incorporated, NJ, 2013, p. 35-46.
Russo MW. Evaluation of the Transplant Candidate. In:Common Liver Diseases and Transplantation An Algorithmic Approach to Work-Up and Management, ed. Brown Jr RS. Slack Incorporated, NJ, 2013, p. 35-46.
Bonkovsky HL, Jones DP, Russo MW, Shedlofsky I. Drug Induced Liver Injury. In:Zakim and Boyer’s Hepatology:A textbook of liver disease 6th edition. Elsevier Saunders, Philadelphia, 2011, p 471-461.
Russo MW, Shrestha RS in McNally PR GI/Liver Secrets Plus Fourth Edition. Evaluation of a liver mass, Mosby Elsevier 2010, p173-179.
Martin Scobey, MD, FACP
Dr. Scobey is the Gastroenterology Fellowship Program Director at Carolinas Medical Center and holds an appointment as a Clinical Professor of Medicine with the University of North Carolina, Chapel Hill. He received his medical degree from the University of Tennessee where he also completed his residency in internal medicine. He subsequently completed his gastroenterology fellowship at the Wake Forest University School of Medicine. His current clinical and research interests relate to esophageal disorders, C. difficile colitis and endoscopic quality improvement.
Current Research Projects
“Variables Affecting Trends in Anesthesia Usage in a Large-Volume Hospital Based Endoscopy Unit”
“Clostridium Difficile Associated Disease: A Retrospective Comparison of Severity of Community Acquired Disease Versus Healthcare Facility Acquired Disease”
Knight N, Strait T, Anthony N, Lovell R, Norton J, Sautter R, Scobey M. Clostridium difficile colitis: a retrospective study of incidence and severity before and after institution of an alcohol based hand rub policy. Am J Infect Control. 2010;38(7):523-528. PMID: 20392538
Narang TK, Sendi H, Scobey MW, Bonkovsky HL. Iron and Hepatitis C. Current Hepatitis Reports 2010;9:169-177.
Hong C, Scobey M, Napenas J, Brennan M, Lockhart P. Dental postoperative bleeding complications in patients with suspected and documented liver disease. Oral Dis. 2012;18(7):661-6. PMID: 22458329
Anthony NE, Blackwell J, Ahrens W, Lovell R, Scobey MW. Intestinal Spirochetosis: An Enigmatic Disease. Dig Dis Sci. 2013;58(1):202-8. PMID:22851039
Woods JA, Wright NJ, Gee J, Scobey MW. Cannabinoid Hyperemesis Syndrome: An Emerging Drug-Induced Disease. Am J Ther 2014 Jan 9. [Epub ahead of print] PMID: 24413371
Michael Zgoda, MD
Dr. Zgoda is the President of the Medical Staff at Carolinas HealthCare System University as well as the Medical Director of the Interventional Pulmonology Service and Intensive Care Unit. He received his medical degree from the University of Kentucky, Lexington in 2000 where he also completed his residency in Internal Medicine and fellowship in Pulmonary/Critical care and sleep medicine. He also holds an MBA from the University of Massachusetts, Amherst.
Dr. Zgoda’s current research interests include surgical and medicinal interventions to treat severe chronic obstructive pulmonary disease. He is the principal investigator at Carolinas Medical Center for the EMPROVE (A Prospective, Randomized, Controlled Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Single-Lobe Treatment of Severe Emphysema) clinical research trial.