Research and Clinical Trials

Title  
GOG 0275
Brief Description  
The purpose of this study is to compare actinomycin-D and methotrexate to find out which works better to control GTN (gestational trophoblastic neoplasia) with the fewest side effects and least interruption in normal daily living. Subjects are randomized to either actinomycin-D given IV (injection a vein) or methotrexate IV or IM (injection into a muscle) with oral leucovorin. This study includes quality of life questionnaires to be completed periodically throughout treatment.
Who may be Eligible  
-Low-risk GTN: post molar GTN or choriocarcinoma -Adequate blood counts, kidney, and liver function -No prior pelvic radiation allowed -No previous invasive cancers within the last 5 years
IRB Number  
##-##-##A
Principal Investigator  
Higgins, Robert

For More Information, Contact  Sarah  , Norek
Phone:  (704) 355-1520  Fax:  (704) 355-9897  
Email:  Sarah.Norek@carolinashealthcare.org
Address:1025 Morehead Medical Drive Charlotte, NC
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