|Brief Description||Principal Investigator|
|The primary objective of this study is to evaluate safety and tolerability and select a recommended Phase 2 dose (RP2D) of ADXS31-164 in subjects with solid tumors that express HER2||Tan, Antoinette Roslyn|
|To describe the anti-tumor activity (efficacy) and toxicity (safety) of commercially available, targeted anti-cancer drugs used for treatment of patients with advanced solid tumors, multiple myeloma or B cell non-Hodgkin lymphoma with a genomic variant known (i) to be a target of an FDA-approved anti-cancer drug or (ii) to predict sensitivity to an FDA-approved anti-cancer drug.||Kim, Edward Sanghyun|
|To investigate the safety and tolerability of selumetinib when given in combination with MEDI4736 to patients with advanced solid malignancies.||Kim, Edward Sanghyun|
|The purpose of this study is to evaluate the objective response rate (ORR) of nivolumab monotherapy or nivolumab combined with ipilimumab in subjects with advanced or metastatic tumors.||Amin, Asim|
To evaluate the time to treatment failure (TTF) in LAPC subjects treated with
nab-paclitaxel plus gemcitabine as induction therapy followed by Investigator?s
Choice of treatment
|Hwang, Jimmy John|
|Celgene ABI-007-ST-001||Carrizosa, Daniel Ricardo|
I. To maintain a Childhood Cancer Registry for infants, children, adolescents, and young adults with cancer.
II. To utilize clinical and biological data to help determine eligibility or stratification, based on childhood cancer disease classification schemas, for potential enrollment of research subjects onto Children's Oncology Group (COG) therapeutic clinical trials.
III. To develop a well annotated childhood cancer biobank for current and future research through the collection of biospe
|Kaplan, Joel Adam|
Primary: To assess the potential benefit of regorafenib in the treatment of advanced previously-treated pancreatic cancer.
Secondary: Critical examination of Response Rate (RR), Disease Control Rate (DCR, defined as CR+Pr+SD), Overall Survival (OS), and toxicity.
Exploratory: Tissue and blood samples will be collected for exploratory biomarker analyses.
|Salmon, John Stuart|