Carolinas HealthCare System

Research and Clinical Trials

Hodgkin's Lymphoma 

Brief Description PrincipalĀ Investigator
The purpose of this study is to establish a biologic specimen repository (of tumor tissue, tissue arrays, lymphoblastoid cell lines, host DNA, tumor and host RNA, serum, and plasma) and database linked to clinical features and outcomes from well-characterized cohorts of children and young adults with Hodgkin's lymphoma. Kaplan, Joel Adam 
To evaluate the feasibility of ABVD followed by brentuximab vedotin
consolidation in patients with previously untreated stage I or II non-bulky HL
based on the percentage of patients who achieve complete response (CR) by PET
post treatment.
Ghosh, Nilanjan 
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda Rene 
This open-label, randomized, 2-arm, multicenter, phase 3 study has the primary objective of comparing the modified progression-free survival (mPFS) obtained with brentuximab vedotin (ADCETRISĀ®) plus AVD (doxorubicin [Adriamycin], vinblastine, and dacarbazine; abbreviated A+AVD) versus that obtained with ABVD (doxorubicin [Adriamycin],bleomycin, vinblastine, and dacarbazine) for the frontline treatment of advanced classical Hodgkin lymphoma(HL)

Ghosh, Nilanjan 
To identify potential biomarkers of primary (intrinsic) resistance in relapsed/refractory Hodgkin lymphoma (HL) patients treated with brentuximab vedotin Ghosh, Nilanjan 
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