Carolinas HealthCare System

Research and Clinical Trials


Brief Description PrincipalĀ Investigator
The primary objective of this study is to evaluate safety and tolerability and select a recommended Phase 2 dose (RP2D) of ADXS31-164 in subjects with solid tumors that express HER2 Tan, Antoinette Roslyn 
The objective is to compare progression free survival (PFS) and overall survival (OS)in patients treated with nintedanib plus BSC and patients treated with placebo plus BSC. Hwang, Jimmy John 
This trial is studying giving oxaliplatin, leucovorin calcium, and fluorouracil together to compare how well they work when given together with or without celecoxib in treating patients with stage III colon cancer previously treated with surgery. Salmon, John Stuart 
Estimate PFS in previously untreated mCRC patients receiving FOLFIRI + bevacizumab when irinotecan dose is based on UGT1A1 genotype Patel, Jai Narendra 
Phase I: The primary objective is to determine the safety and tolerability of Cetuximab and Neratinib in patients with metastatic colorectal cancer; Primary Tumor "Quadruple Wild-Type".
Phase II: The primary objective is to determine the overall response rate (ORR) and progression-free (PFS) survival rate at 16 weeks in patients with measurable metastatic Colorectal Cancer treated with Cetuximab and Neratinib.
Hwang, Jimmy John 
To identify subpopulations of registry patients on the basis of their molecular profiles that may be eligible for participation in available NSABP clinical trials involving novel agents. Hwang, Jimmy John 
To describe the long term safety, and clinical outcomes of aflibercept in combination with FOLFIRI in patients treated in daily practice for a metastatic CRC after failure of an oxaliplatin-based regimen. Nazemzadeh, Reza 
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