Research and Clinical Trials

Brief Description Principal Investigator
The primary objective of this study is to evaluate safety and tolerability and select a recommended Phase 2 dose (RP2D) of ADXS31-164 in subjects with solid tumors that express HER2 Tan, Antoinette Roslyn
To evaluate whether radiation to the undissected axilla and regional lymph nodes is not inferior to axillary lymph node dissection with radiation to the regional lymph nodes but not to the dissected axilla in terms of invasive breast cancer recurrence-free interval in patients with positive SLN(s) after completion of neoadjuvant chemotherapy
White, Richard Laverne
To describe the anti-tumor activity (efficacy) and toxicity (safety) of commercially available, targeted anti-cancer drugs used for treatment of patients with advanced solid tumors, multiple myeloma or B cell non-Hodgkin lymphoma with a genomic variant known (i) to be a target of an FDA-approved anti-cancer drug or (ii) to predict sensitivity to an FDA-approved anti-cancer drug. Kim, Edward Sanghyun
To investigate the safety and tolerability of selumetinib when given in combination with MEDI4736 to patients with advanced solid malignancies. Kim, Edward Sanghyun
Primary objective
 To evaluate the safety and tolerability of AZD1775 monotherapy administered in 21-day cycles for patients with advanced solid tumours (BID PO x 3 days [weeks 1 and 2]).

Secondary objectives
 To evaluate the anti-tumour activity of AZD1775 monotherapy in previously treated patients with ovarian cancer, triple-negative breast cancer (TNBC) and small cell lung cancer (SCLC).
 To characterise the pharmacokinetic (PK) profile of AZD1775.
 To c
Tan, Antoinette Roslyn
The purpose of this study is to evaluate the objective response rate (ORR) of nivolumab monotherapy or nivolumab combined with ipilimumab in subjects with advanced or metastatic tumors. Amin, Asim
Celgene ABI-007-ST-001 Carrizosa, Daniel Ricardo
I. To maintain a Childhood Cancer Registry for infants, children, adolescents, and young adults with cancer.

II. To utilize clinical and biological data to help determine eligibility or stratification, based on childhood cancer disease classification schemas, for potential enrollment of research subjects onto Children's Oncology Group (COG) therapeutic clinical trials.

III. To develop a well annotated childhood cancer biobank for current and future research through the collection of biospe
Kaplan, Joel Adam
The primary efficacy objective is to estimate the efficacy of ipatasertib combined with paclitaxel compared with placebo combined with paclitaxel in patients with early stage TNBC, as measured by local pathology laboratory evaluation of pCR rate within the breast and exilla (ypT0/Tis ypN0) in all patients and in patients with PTEN-low tumors. Fisher, Julie Gottlieb
Primary: to compare radioactive seed localization (RSL) and wire-guided localization (WL) based on negative margins in malignant disease where negative margins is defined as no tumor on ink in invasive disease, and greater than or equal to 2mm from the inked margin in non-invasive disease (DCIS).
Secondary: to compare RSL and WL base on the following: total procedure cost, subject satisfaction over time, time from subject consult to operating room, radiologist satisfaction, time in radiology, s
Hadzikadic-Gusic, Lejla
The primary objective is to assess the safety, describe the DLTs, and determine the MTD or the maximum administered dose (MAD; in the absence of exceeding the MTD) for MEDI4276 administered as a single agent in subjects with HER2-expressing advanced breast or gastric cancer refractory to standard therapy or for which no standard therapy exists. Tan, Antoinette Roslyn
To evaluate the objective response rate (ORR) to pembrolizumab as 2L+ monotherapy in subjects with PD-L1(+)high centrally confirmed mTNBC, based on RECIST 1.1 as assessed by central radiology review. Tan, Antoinette Roslyn
To determine whether the addition of carboplatin to an adjuvant chemotherapy regimen of doxorubicin/cyclophosphamide followed by paclitaxel will improve the invasive disease-free survival (IDFS) compared to doxorubicin/cyclophosphamide followed by paclitaxel when administered to patients with operable node-positive or high-risk node-negative triple-negative breast cancer. Vallabhaneni, Geetha
This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whether comprehensive radiation therapy is more effective than standard radiation therapy in treating patients with breast cancer. Sharp, Hadley Jean
The primary objective is to assess the effect of adjuvant treatment with olaparib on Invasive Disease Free Survival (IDFS). Tan, Antoinette Roslyn
The primary safety objective for this study is to evaluate the safety and tolerability of the
following combination treatments administered q3w to patients with HER2-positive MBC
or operable LABC or inflammatory EBC:
? Atezolizumab in combination with trastuzumab and pertuzumab
? Atezolizumab in combination with trastuzumab emtansine
Fisher, Julie Gottlieb
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