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Toan Huynh

Toan Huynh, MD

Toan Huynh, MD

Department of General Surgery
Division of Trauma, Surgical Critical Care and Acute Care Surgery
Director for Trauma Research
Director, Surgical Intensive Care Unit, Carolinas Medical Center
Director, Surgical Critical Care Fellowship
Adjunct Associate Professor of Biology, University of North Carolina at Charlotte
Clinical Associate Professor of Surgery, University of North Carolina at Chapel Hill
Associate Graduate Faculty, Department of Computer Science, University of North Carolina at Chapel Hill
Medical Director, Department of Respiratory Therapy, Central Piedmont Community College

Training and Education


Fellow, Trauma/Critical Care, University of North Carolina (Chapel Hill, NC)

Fellow, NIH-NRSA, University of North Carolina (Chapel Hill, NC)

Resident, General Surgery, University of North Carolina (Chapel Hill, NC)


MD: 1990, University of Washington School of Medicine (Seattle, WA)
BS: 1986, Microbiology and Immunology, University of Washington (Seattle, WA)

Recent Interests

The F.H. “Sammy” Ross Jr. Trauma Center’s laboratory for basic and clinical sciences focuses on studying the effects of systemic inflammation on microcirculation after injuries. Current research projects include the mechanisms of hepatic microcirculatory alterations after trauma and sepsis and the heterogeneity of liver blood flow after systemic stress. These experimental studies examine the pattern of gene expression, organ blood flow at the microcirculatory levels and oxygen transport in the liver. Dr. Huynh continues ongoing collaborations with Mark Clemens, PhD, in the Department of Biology, and Min Shin, PhD, in the Department of Computer Science at the University of North Carolina at Charlotte. Using sophisticated assays for gene analyses, intravital video microscopy and complex computational methodologies, these investigators have gained further insight into the alteration of blood flow patterns during systemic stress. On-going clinical trials examine the therapeutic benefits of chemotherapeutic agents for traumatic brain injuries; as well as the efficacy of new technologies in the operative interventions after severe torso injuries. These research efforts have generated extramural and intramural funding.

Select Publications

Sirleaf M, Jefferson B, Christmas AB, Sing RF, Thomason MH, Huynh TT. Comparison of procedural complications between resident physicians and advanced clinical providers. J Trauma Acute Care Surg 2014;77(1):143-7. PMID: 24977769

Powell RD, Swet JH, Kennedy KL, Huynh TT, McKillop IH, Evans SL. Resveratrol attenuates hypoxic injury in a primary hepatocyte model of hemorrhagic shock and resuscitation. J Trauma Acute Care Surg 2014;76(2):409-17. PMID: 24458046

Moore CC, McKillop IH, Huynh TT. MicroRNA expression following activated protein C treatment during septic shock. J Surg Res 2013;182(1):116-26. PMID: 22940033

Yu A, Teitelbaum J, Scott J, Gesin G, Russell B, Huynh T, Skrobik Y. Evaluating pain, sedation, and delirium in the neurologically critically ill-feasibility and reliability of standardized tools: a multi-institutional study. Crit Care Med 2013;41(8):2002-7. PMID: 23863231

Wormer BA, Fleming GP, Christmas AB, Sing RF, Thomason MH, Huynh T. Improving overtriage of aeromedical transport in trauma: a regional process improvement initiative. J Trauma Acute Care Surg 2013;75(1):92-6. PMID: 23778445

Klima DA, Hanna EM, Christmas AB, Huynh TT, Etson KE, Fair BA, Green JM, Madjarov J, Sing RF. Endovascular graft repair for blunt traumatic disruption of the thoracic aorta: experience at a nonuniversity hospital. Am Surg 2013;79(6):594-600. PMID: 23711269

Frankel HL, Butler KL, Cuschieri J, Friese RS, Huynh T, Mohr AM, Schinco MA, Napolitano LM, Britt LD, Coimbra R, Croce MA, Davis JW, Jurkovich GH, Moore EE, MOrris JA Jr, Peitzman AB, Pruitt BA, Rozycki GS, Scalea TM, Meredith JW. The role and value of surgical critical care, an essential component of Acute Care Surgery, in the Affordable Care Act: a report from the Critical Care Committee and Board of Managers of the American Association for the Surgery of Trauma. J Trauma Acute Care Surg 2012;73(1):20-6. PMID: 22743368

Montegudo AE, Palilonis MA, Moore CC, Huynh TT, McKillop IH, Evans SL. Pyrrolidine dithiocarbamate improves mortality in a rat model of severe hemorrhage. J Surg Res 2013;179(1):E149-55. doi:10.1016/j.jss.2012.01.006

Brintzenhoff RA, Christmas AB, Braxton VG, Janulis KE, Huynh TT, Sing RF. Mopeds: the legal loophole for repeat driving while intoxicated offenders. Am J Surg 2011;202(6):697-700. PMID: 22137136

Kellers SA, Moore CC, Clemens MG, McKillop IH, Huynh T. Activated protein C restores hepatic microcirculation during sepsis by modulating vasoregulator expression. Shock 2011;36(4):361-9. PMID: 21897335

Nguyen NH, Keller S, Norris E, Huynh TT, Clemens MG, Shin MC. Tracking colliding cells in vivo microscopy. IEEE Trans Biomed Eng 2011;58(8). PMID: 21632294

Keller SA, Moore CC, Evans SL, McKillop IH, Huynh T. Activated protein C alters inflammation and protects renal function in sepsis. J Surg Res 2011;168(1):e103-9. PMID: 21429520

Huynh T, Nguyen N, Keller S, Moore C, Shin M, McKillop IH. Leukocyte Trafficking Preserves Hepatic Function after Sepsis. J Trauma 2010;69(2)360-367. DOI: 10.1097/TA.0b013e3181e65133.

Huynh T, Blackburn A, McMiddleton-Nyatui D, Moran K, Thomason MH, Jacobs DG. An Initiative by Mid-level Providers to Conduct Tertiary Survey at a Level-I Trauma Center. J Trauma 2010;68:1052-1058. DOI: 10.1097/TA.0b013e3181d87789.

Ji SY, Smith R, Huynh T, Najarian K. A comparative analysis of multi-level computer-assist decision making systems for traumatic injuries. BMC Med Info Decision Making 2009;9:2. DOI:10.1186/1472-6947-9-2.

Schmugge SJ, Keller S, Nguyen N, Souvenir R, Huynh T, Clemens MG, Shin MC. Segmentation of vessels clustered with cells using a physics based model. Med Image Comput Comput Assist Interv, Lecture Notes in Computer Science 2008;5241:127-134 [PMID: 18979740]

Huynh T, Moran K, Blackburn A, Jacobs DG, Thomason MH, Sing RF. Optimal management strategy for incidental findings in trauma patients: an initiative for mid-level providers. J Trauma 2008;65:331-336 [PMID: 18695467]

Jacobs DG, Sarafin JL, Huynh T, Miles WS, Sing RF, Thomason MH. Audience response system technology improves accuracy and reliability of trauma outcome judgments. J Trauma 2006; 61: 135-143. [PMID: 16832261]

Huynh T, Jacobs DG, Dix S, Sing RF, Miles WS, Thomason MH. Utility of neurosurgical consultation for mild traumatic brain injury. Am Surg 2006; 72: 1162-1167. [PMID: 17216813]

Kamoun WS, Shin MC, Keller S, Karaa A, Huynh T, Clemens MG. Induction of biphasic changes in perfusion heterogeneity of rat liver after sequential stress in vivo. Shock 2005; 24: 324-331. [PMID: 16205316]

Burns JM, Sing RF, Mostafa G, Huynh T, Jacobs DG, Miles WS, Thomason MH. The role of transesophageal echocardiography in optimizing resuscitation in acutely injured patients. J Trauma 2005; 59: 36-42. [PMID: 16096536]

Paxian M, Keller SA, Baveja R, Korneszczuk K, Huynh T, Clemens MG. Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver. Microcirculation 2004; 11: 435-449. [PMID: 15280069]

Current, Recent and Pending Grant Support

Grant Title: Information Integration and Processing for Computer Aided Trauma Decision Making
Funding Agency: National Science Foundation
Role: Co-Principal Investigator
Years: 2007-2010

Grant Title: Role of micro-RNA in hepatic microcirculatory failure during sepsis
Funding Agency: Carolinas HealthCare System - Education & Research Foundation
Principal Investigator: Cathy Moore, PhD, Post-doctoral Fellow
Co-Principal Investigator:Toan Huynh, MD

Grant Title: Hepatic Microcirculatory Dysfunction after Trauma and Sepsis
Funding Agency: American Association for the Surgery of Trauma
Role: Principal Investigator
Years: 2003-2006

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