Currently, there are no recommendations for preventing sarcoma, whether it starts in the bone or soft tissue. Certain genetic conditions can increase risk, but many cases of sarcoma occur in people who have no known risk factors.

Radiation is one risk factor for these sarcomas, however, people receiving radiation for other cancers often have no choice and cannot avoid this exposure. Exposure to certain chemicals, such as herbicides, on the job may be linked to soft-tissue sarcoma, although this link has not been proven.

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