Carolinas HealthCare System

Ting Li, PhD
Research Scientist, Liver Pathology Laboratory
Carolinas HealthCare System

Prior Positions and Experience

2008–present Research Scientist, Liver Pathology Laboratory, Carolinas Medical Center
2002-07 Postdoctoral Associate, Oak Ridge National Laboratory/University of Georgia

Education

PhD: 2002, University of Kentucky
BS: 1993, Nankai University (Tianjin, China)

Research Interests

Dr. Li is interested in the function and regulation of nuclear receptors such as Rev-erbs in liver diseases.

Recent Publications

Bonkovsky HL, Hou W, Steuerwald N, Tian Q, Li T, Parsons J, Hamilton A, Hwang S, Schrum LW.  Heme status affects human hepatic messenger RNA and microRNA expression.  World J Gastroenterol. 2013 Mar 14;19(10):1593-601. [PMID: 23538684].

Bonkovsky HL, Guo JT, Hou W, Li T, Narang T, Thapar M. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan 1;3(1):365-401. [PMID:23720291].

Lakner AM, Steuerwald NM, Walling TL, Ghosh S, Li T, McKillop IH, Russo MW, Bonkovsky HL, Schrum LW.  Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology. 2012 Jan 25. Jul;56(1):300-10. [PMID: 22278637]

Tian Q, Li T, Hou W.H, et al. Lon Peptidase 1 (LONP1)-dependent Breakdown of Mitochondrial 5-Aminolevulinic Acid Synthase Protein by Heme in Human Liver Cells.  J. Biol. Chem. 2011 286: 26424-26430.   [PMID: 21659532]

Li T, Bonkovsky H, and Guo J.T. Structural analysis of heme proteins: implications for design and prediction.   BMC Structural Biology 2011, 11:13 [PMID: 21371326] 

Strand KR, Sun C, Li T, Jenney FE Jr, Schut GJ, Adams MW. Oxidative stress protection and the repair response to hydrogen peroxide in the hyperthermophilic archaeon Pyrococcus furiosus and in related species. Arch Microbiol. 2010 Jun;192(6):447-59. Epub 2010 Apr 9. [PMID: 20379702] 

Liu Z., Guo J.T., Li T., Xu Y. Structure-based recognition of binding sites of transcription factors using an efficient protein-DNA docking approach. Proteins: Structure, Function, and Bioinformatics, 72(4),1114-1124, 2008. [PMID: 18320590]

Wang BC, Adams MW, Dailey H, DeLucas L, Luo M, Rose J, Bunzel R, Dailey T, Habel J, Horanyi P, Jenney FE Jr, Kataeva I, Lee HS, Li S, Li T, Lin D, Liu ZJ, Luan CH, Mayer M, Nagy L, Newton MG, Ng J, Poole FL 2nd, Shah A, Shah C, Sugar FJ, Xu H. Protein production and crystallization at SECSG – an overview. J Struct Funct Genomics. 2005, 6(2-3):233-43. [PMID: 16211524]

Li T., Zhang J. Stable expression of three genes from a tricistronic retroviral vector containing a picornavirus and 9-nt cellular internal ribosome entry site elements. Journal of Virological Methods. 2004, Feb:115(2):137-44. [PMID: 14667529]

Li T., Zhang J. Intramolecular recombinations of moloney murine leukemia virus occur during minus-strand DNA synthesis. Journal of Virology. 2002, 76:9614-9623. [PMID: 12208940]

Li T., Zhang J. Retroviral recombination is temperature-dependent. Journal of General Virology. 2001, 82:1359-1364. [PMID: 11369880]

Li T., Zhang J. Determination of the frequency of retrovial recombination between two identical sequences within a provirus. Journal of Virology. 2000, 74:7646-7650. [PMID: 10906220]

Zhang J., Tang L., Li T., and Sapp C. Most retroviral recombination occurs during minus-strand DNA synthesis. Journal of Virology. 2000, 74:2312-2322. [PMID: 10666262]

Sapp C., Li T., Zhang J. Systematic comparison of a color reporter gene and drug resistance genes for determination of retroviral titers. Journal of Biomed Sci. 1999, 6:342-348. [PMID: 10494041]

Current, Recent and Pending Grant Support

Grant Title:  Tenascin-C as a therapeutic target and biomarker for obesity-induced HCC
Funding Agency:  Charlotte Medical Center
Role: Co-Investigator
Years: 2013-2014

Grant Title: Heme homeostasis and nuclear receptor signaling in HSC
Funding Agency: Charlotte Health Science Service Foundation
Role: Principal Investigator
Years: 2010 - 2012

Grant Title: An Integrative Approach to Study the Transcriptional Regulation of ALAS1 by Heme
Funding Agency: Carolinas HealthCare System University of North Carolina at Charlotte
Role: Principal Investigator
Years: 2009-2010

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