Paul Thomes
Paul G. Thomes, PhD
Research Scientist
Liver Pathobiology Laboratory
James G. Cannon Research Center
Prior Positions and Experience
2007-2009
Associate Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)
2001-2007
Assistant Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)
2000-2001
Research Assistant Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)
1997-2000
Research Analyst, Department of General Surgery, University of North Carolina at Chapel Hill (Chapel Hill, NC)
1993-1997
Postdoctoral Fellow, NIH National Research Service Award, Department of Medicine, University of North Carolina at Chapel Hill (Chapel Hill, NC)
Education
BS (Summa Cum Laude): 1988, North Carolina State University (Raleigh, NC)
PhD: 1993, North Carolina State University (Raleigh, NC)
Recent Publications
Sendi H, Mehrab-Mohseni M, Foureau DM, Ghosh S, Walling TL, Steuerwald N, Zamor PJ, Kaplan KJ, Jacobs C, Ahrens WA, Russo MW, CLemens MG, Schrum LW, Bonkovsky HL. MiR-122 decreases HCV entry into hepatocytes through binding to the 3' UTR of OCLN mRNA. Liver Int. 2015;35(4):1315-23. PMID: 25302477
Li T, Eheim AL, Klein S, Uschner FE, Smith AC, Brandon-Warner E, Ghosh S, Bonkovsky HL, Trebicka J, Schrum LW. Novel role of nuclear receptor Rev-erbα in hepatic stellate cell activitation: potential therapeutic target for liver injury. Hepatology. 2014;59(6):2283-96. PMID: 24497272
Bonkovsky HL, Hou W, Steuerwald N, Tian Q, Li T, Parsons J, Hamilton A, Hwang S, Schrum L. Heme status affects human hepatic messenger RNA and microRNAs expression. World J Gastroenterol. 2013;19:1593-1601. [PMID: 23538684]
Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL. Cytoskeletal proteins: shaping progression of hepatitis C virus-induced liver disease. Int Rev Cell Mol Biol. 2013;302:279-319. [PMID: 23351713]
Lakner AM, Steuerwald NM, Schrum LW. Reply to HEP-12-0853.R3. Hepatology. 2013;57:1286-7. See article
Brandon-Warner E, Schrum LW, Schmidt CM, McKillop IH. Rodent models of alcoholic liver disease: Of mice and men. Alcohol. 2012;46:715-25. [PMID: 22960051]
Brandon-Warner E, Eheim AL, Foureau DM, Walling TL, Schrum LW, McKillop IH. Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice. Cancer Lett. 2012;326:88-95. [PMID: 22863537]
Brandon-Warner E, Walling TL, Schrum LW, McKillop IH. Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis. Alcohol Clin Exp Res. 2012;36:641-53. [PMID: 22017344]
Hou W, Tian Q, Steuerwald NM, Schrum LW, Bonkovsky HL. The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes. Biochim Biophys Acta. 2012;1819:1113-22. [PMID: 22698995]
Lakner AM, Steuerwald N, Walling T, Ghosh S, McKillop IH, Russo MW, Bonkovsky HB, Schrum LW. Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology. 2012;56:300-10. [PMID: 22278637]
Osna N, Kharbanda K, Schrum L, Dolganiuc A. Advances in alcoholic liver disease. Int J Hepatol. 2012:563018. See article
Lakner AM, Walling TL, McKillop IH, Schrum LW. Altered aquaporin expression and role in apoptosis during hepatic stellate cell activation. Liv. Int. 2011 Jan;31(1):42-51. [PMID: 20958918]
Day SA*, Lakner AM*, Moore CC, Yen MH, Clemens MG, Wu ES, Schrum LW. Opioid-like compound exerts anti-fibrotic activity via decreased hepatic stellate cell activation and inflammation. Biochem Pharmacol. 2011;81(8):996-1003. [PMID: 21291870] *Both authors contributed equally to this manuscript
Thompson KJ, Lakner AM, Cross BW, Tsukada S, Rippe RA, McKillop IH, Schrum LW. S-adenosyl-L-methionine inhibits collagen secretion in hepatic stellate cells via increased ubiquitination. Liver Int. 2011;31:891-901. [PMID: 21645221]
Mehrab-Mohseni M, Sendi H, Steuerwald N, Ghosh S, Schrum LW, Bonkovsky HL. Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV. World J Gastroenterol. 2011;17:1694-1700. [PMID: 21483629]
Tian Q, Li T, Hou W, Zheng J, Schrum LW, Bonkovsky HL. Lon Peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. J. Biol. Chem. 2011;286:26424-30. [PMID: 21659532]
Moore CC, Lakner AM, Yengo CM and Schrum LW. Identification and function of nonmuscle myosin II isoforms in hepatic stellate cells. World J Hepatol. 2011;3:184-97. [PMCID: PMC3158907]
Sokolov E, Schrum LW, McKillop IH. Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma. Cell Signal. 2011;23:1603-10. [PMID: 21620966]
Lakner AM, Bonkovsky HL, Schrum LW. microRNAs: fad or future of liver disease. World J Gastroenterol. 2011;17:2536-42. [PMID: 21633658]
Thompson KJ, McKillop IH, Schrum LW. Targeting collagen expression in alcoholic liver disease. World J Gastroenterol. 2011;17:2473-81. [PMCID: PMC3103805]
Ghosh S, Ahrens WA, Phatak SU, Hwang S, Schrum LW, Bonkovsky HL. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J Viral Hepat. 2011;18:e568-77. [PMID: 21914078]
Hwang SI, Lee YY, Park JO, Norton HJ, Clemens E, Schrum LW, Bonkovsky HL. Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by an improved LC-MS/MS method. Clinica Chemica Acta. 2011;412:2241-7. [PMID: 21867695]
Ellefson WM, Lakner AM, Hamilton A, McKillop IH, Bonkovsky HL, Steuerwald NM, Huet YM, Schrum LW. Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen. PLoS ONE. 2011;6(12):e29463. [PMID: 22206017]
Brandon-Warner E, Sugg JA, Schrum LW, McKillop IH. Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in rat hepatocellular carcinoma cells. Cancer Lett. 2010;291(1):120-9. [PMID: 19900758]
Lakner AM, Moore CC, Gulledge AA, Schrum LW. 2010. Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation. World J Gastroenterol. 2010;16(40):5047-56. [PMCID: PMC2965281]
McKillop IH, Schrum LW. Role of Alcohol in Liver Carcinogenesis. Semin. Liver Dis. 2009;29(2):222-32. [PMID: 19387921]
Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA. Inhibition of Phosphatidylinositol 3-Kinase Signaling in Hepatic Stellate Cells Blocks the Progression of Hepatic Fibrosis. Hepatology. 2009;50(5):1512-23. [PMID: 19790269]
Karaa A*, Thompson KJ*, McKillop IH, Clemens MG, Schrum LW. S-Adenosyl-L-Methionine (SAMe) Attenuates Oxidative Stress and Hepatic Stellate Cell Activation in an Ethanol-Lipopolysaccharide (LPS)-Induced Fibrotic Rat Model. Shock. 2008;30:197-205. [PMID: 18180699] *Both authors contributed equally to this manuscript
Zheng J, Tian Q, Hou W, Watts JA, Schrum LW, Bonkovsky HL. Tissue-specific Expression of ALA Synthase-1 and Heme Oxygenase-1 and Their Expression in Livers of Rats Chronically Exposed to Ethanol. FEBS Lett. 2008;582(13):1829-34. [PMID: 18472004]
Current, Recent and Pending Grant Support
Tenascin-C as a therapeutic target and biomarker for obesity-induced HCC
Funding Agency: Atrium Health
Role: Co-Principal investigator (David Sindram)
Years: 01/01/14-12/31/14
Goal: To delineate the cellular mechanism of tenascin-C in obesity-induced HCC
Role of microRNAs in HSC-mediated fibrogenesis
Funding Agency: NIH/NIAAA - R21
Role: Principal Investigator
Years: 12/01/2013 - 11/30/2015
Goal: To determine the role of miR19b in HSC-mediated fibrosis and test this miR as an effective anti-fibrotic molecule