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Orthopedics

CMC Orthopaedic Clinical Research (OCR)

The Clinical Research Division of the Orthopaedic Department coordinates the multiple patient-based research activities of the Carolinas Medical Center faculty and residents. Primarily tasked with the conduct of surgeon initiated critical clinical impact studies, the OCR Division works within the Carolinas Medical Center, in coordination with other major medical centers and in partnerships with UNCC and industry in efforts to improve the long term functional outcomes of patients with impairing musculoskeletal conditions. The research ranges from early translational studies, through industry-sponsored FDA clinical trials and to national or locally funded prospective studies addressing the current treatment controversies in the specialty. Specific areas of interest include trauma-related care (fracture fixation and healing), infections, total joint replacements, bone and soft tissue tumor, spinal instability and degenerative conditions and pediatric conditions. Functional outcome research is a critical component in all of the prospective research.

OCR Faculty and Research Interests

Michael J. Bosse, MD

Michael J. Bosse, MD
Director, Orthopaedic Clinical Research
1320 Scott Avenue
Charlotte, NC 28203

Undergraduate School: U.S.Naval Academy
Medical School: University of Maryland
Residency: Orthopaedic Surgery, Naval Hospital of San Diego
Fellowship: Trauma Surgery, Baltimore Shock Trauma Center
Specialty: Complex orthopaedic fractures and deformities resulting from injury

Research Interests: Outcomes Research, Fracture and Injury Related, Infections and Osteomyelitis

Recent Publications

MacKenzie EJ, Jones AS, Bosse MJ, Castillo RC, Pollak AN, Webb LX, Swiontkowski MF, Kellam JF, Smith DG, Sanders RW, Jones AL, Starr AJ, McAndrew MP, Patterson BM, Burgess AR. Health-care costs associated with amputation or reconstruction of a limb-threatening injury.
J Bone Joint Surg Am 2007; 89: 1685-1692. [PMID: 05176710]

Webb LX, Bosse MJ, Castillo RC, MacKenzie EJ; LEAP Study Group. Analysis of surgeon-controlled variables in the treatment of limb-threatening type-III open tibial diaphyseal fractures. J Bone Joint Surg Am 2007; 89: 923-928. [PMID: 17473126]

Karunakar MA, Sen A, Bosse MJ, Sims SH, Goulet JA, Kellam JF. Indometacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum.
J Bone Joint Surg Br 2006; 88: 1613-1617. [PMID: 17159174]

MacKenzie EJ, Bosse MJ, Kellam JF, Pollak AN, Webb LX, Swiontkowski MF, Smith DG, Sanders RW, Jones AL, Starr AJ, McAndrew MP, Patterson BM, Burgess AR, Travison T, Castillo RC. Early predictors of long-term work disability after major limb trauma. J Trauma.2006; 61: 688-694. [PMID: 16967009]

Bosse MJ, McCarthy ML, Jones AL, Webb LX, Sims SH, Sanders RW, MacKenzie EJ; The Lower Extremity Assessment Project (LEAP) Study Group. The insensate foot following severe lower extremity trauma: an indication for amputation? J Bone Joint Surg Am 2005; 87: 2601-2608. [PMID: 16322607]

Steven Frick, MD

Steven Frick, MD
Department of Orthopaedic Surgery
1616 Scott Avenue
Charlotte, N.C. 28203

Undergraduate School: George Washington University
Medical School: Medical University of South Carolina
Residency: Orthopaedic Surgery, Carolinas Medical Center
Fellowship: Pediatric Orthopaedics, Children’s Hospital of San Diego
Specialty: Pediatric Orthopaedics

Research Interests: Pediatric Injuries, Clubfoot and Outcomes Research

Recent Publications

Lundeen GA, Masonis JL, Frick SL. Sequelae of pediatric hip disorders: survey responses from experts in adult hip reconstruction. Am J Orthop 2008; 37: 153-156. [PMID: 18438471]

Slongo T, Audigé L, Clavert JM, Lutz N, Frick S, Hunter J. The AO comprehensive classification of pediatric long-bone fractures: a web-based multicenter agreement study. J Pediatr Orthop 2007; 27:171-180. [PMID: 17314642]

Bor N, Herzenberg JE, Frick SL. Ponseti management of clubfoot in older infants. Clin Orthop Relat Res 2006; 444: 224-228. [PMID: 16456307]

Mubarak SJ, Frick S, Sink E, Rathjen K, Noonan KJ. Volkmann contracture and compartment syndromes after femur fractures in children treated with 90/90 spica casts. J Pediatr Orthop 2006; 26: 567-572. [PMID: 16932092]

Moroz LA, Launay F, Kocher MS, Newton PO, Frick SL, Sponseller PD, Flynn JM. Titanium elastic nailing of fractures of the femur in children. Predictors of complications and poor outcome. J Bone Joint Surg Br 2006; 88: 1361-1366. [PMID: 17012428]

Edward Hanley, MD

Edward Hanley, MD
Chairman, Department of Orthopaedic Surgery
1618 Scott Avenue
Charlotte, N.C. 28203

Undergraduate School: Dartmouth College
Medical School: University of Vermont
Residency: Orthopaedic Surgery, University of Pittsburgh
Fellowship: Spine Surgery, University of Pittsburgh
Specialty: Spinal Disease

Research Interests: Coccydynia, Spine Reconstruction and Outcomes Research

Recent Publications

Gruber HE, Hoelscher G, Ingram JA, Chow Y, Loeffler B, Hanley EN Jr. 1,25(OH)2-vitamin D3 inhibits proliferation and decreases production of monocyte chemoattractant protein-1, thrombopoietin, VEGF, and angiogenin by human annulus cells in vitro.
Spine 2008; 33: 755-765. [PMID: 18379402]

Gruber HE, Ingram J, Hoelscher GL, Norton HJ, Hanley EN Jr. Cell polarity in the anulus of the human intervertebral disc: morphologic, immunocytochemical, and molecular evidence.
Spine 2007; 32: 1287-1294. [PMID: 17515816]

Gruber HE, Norton HJ, Sun Y, Hanley EN Jr. Crystal deposits in the human intervertebral disc: implications for disc degeneration. Spine J 2007; 7: 444-450. [PMID: 17630142]

Gruber HE, Gordon B, Williams C, Norton HJ, Hanley EN Jr. Vertebral endplate and disc changes in the aging sand rat lumbar spine: cross-sectional analyses of a large male and female population. Spine 2007; 32: 2529-2536. [PMID: 17978650]

Hanley EN Jr, Mayer HM, Suchomel P. Artificial disc replacement: a benefit to patients? AO Dialogue 2006; 30-33. [Article]

Madhav Karunakar, MD

Madhav Karunakar, MD
Department of Orthopaedic Surgery
1320 Scott Avenue
Charlotte, NC 28203

Undergraduate School: Pomona College
Medical School: Baylor College of Medicine
Residency: Orthopaedic Surgery, University of Cincinnati
Fellowship: Trauma Surgery, Carolinas Medical Center
Specialty: Traumatic Musculoskeletal Conditions

Research Interests: Fractures and Outcomes Research, Injury Related Diabetes

Recent Publications

Femino JE, Gruber BF, Karunakar MA. Safe zone for the placement of medial malleolar screws. J Bone Joint Surg Am 2007; 89:133-138. [PMID: 17200320]

Karunakar MA, Sen A, Bosse MJ, Sims SH, Goulet JA, Kellam JF. Indometacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum. J Bone Joint Surg Br 2006; 88: 1613-1617. [PMID: 17159174]

Karunakar MA, Goulet JA, Mueller KL, Bedi A, Le TT. Operative treatment of unstable pediatric pelvis and acetabular fractures. J Pediatr Orthop 2005; 25: 34-38. [PMID: 15614056]

Bedi A, Karunakar MA, Le TT. Operative treatment of distal tibial metaphyseal fractures. J Amer Acad Orthop Surg 2006; 14: 406-416.

Karunakar MA, Shah SN, Jerabek S. Body mass index as a predictor of complications after operative treatment of acetabular fractures. J Bone Joint Surg Am 2005; 87:1498-1502. [PMID: 15995116]

James Kellam, MD

James Kellam, MD
Department of Orthopaedic Surgery
1616 Scott Avenue
Charlotte, N.C. 28203

Undergraduate School: University of Toronto
Medical School: University of Toronto
Residency: Orthopaedic Surgery, University of Toronto
Fellowship: Orthopaedic Traumatology, Davos, Switzerland and University of Washington
Specialty: Musculoskeletal Injury

Research Interests: Fracture Healing, Bone Substitute, Outcomes Research

Recent Publications

MacKenzie EJ, Bosse MJ, Kellam JF, Pollak AN, Webb LX, Swiontkowski MF, Smith DG, Sanders RW, Jones AL, Starr AJ, McAndrew MP, Patterson BM, Burgess AR, Travison T, Castillo RC. Early predictors of long-term work disability after major limb trauma. J Trauma 2006; 61: 688-694. [PMID: 16967009]

Karunakar MA, Sen A, Bosse MJ, Sims SH, Goulet JA, Kellam JF. Indometacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum. J Bone Joint Surg Br 2006; 88: 1613-1617. [PMID: 17159174]

Smith JJ, Agel J, Swiontkowski MF, Castillo R, Mackenzie E, Kellam JF; LEAP Study Group. Functional outcome of bilateral limb threatening: lower extremity injuries at two years postinjury. J Orthop Trauma 2005;19: 249-253. [PMID: 15795573]

MacKenzie EJ, Bosse MJ, Pollak AN, Webb LX, Swiontkowski MF, Kellam JF, Smith DG, Sanders RW, Jones AL, Starr AJ, McAndrew MP, Patterson BM, Burgess AR, Castillo RC. Long-term persistence of disability following severe lower-limb trauma. Results of a seven-year follow-up. J Bone Joint Surg Am 2005; 87: 1801-1809. [PMID: 16085622]

Audigé L, Griffin D, Bhandari M, Kellam J, Rüedi TP. Path analysis of factors for delayed healing and nonunion in 416 operatively treated tibial shaft fractures. Clin Orthop Relat Res 2005; 438: 221-232. [PMID: 16131895]

Jeffrey Kneisl, MD

Jeffrey Kneisl, MD
Department of Orthopaedic Surgery
1618 Scott Avenue
Charlotte, N.C. 28203

Undergraduate School: Northwestern University
Medical School: Northwestern University
Residency: Orthopaedic Surgery, Northwestern University
Fellowship: Musculoskeletal Oncology, University of Chicago
Specialty: Musculoskeletal Oncology

Research Interests: Musculoskeletal Oncology

Recent Publications

Kneisl JS, Patt JC, Johnson JC, Zuger JH. Is PET useful in detecting occult nonpulmonary metastases in pediatric bone sarcomas? Clin Orthop Relat Res 2006; 450: 101-104. [PMID: 16906103]

Tenholder MJ, Kneisl JS, Harrow ME, Peindl RD, Stanley KJ. Biomechanical effects of processing bulk allograft bone with negative-pressure washing. Am J Orthop 2003; 32: 289-297. [PMID: 12834192] (2003 Resident Writer’s Award)

Wakely P Jr, Frable WJ, Kneisl JS. Soft tissue aspiration cytopathology of malignant lymphoma and leukemia. Cancer 2001; 93: 35-39. [PMID: 11241264]

David Mauerhan, MD

David Mauerhan, MD
Department of Orthopaedic Surgery
1618 Scott Avenue
Charlotte, N.C. 28203

Undergraduate School: Duke University
Medical School: University of Cincinnati
Residency: Orthopaedic Surgery, University of California
Specialty: Adult reconstruction and total joint replacement

Research Interests: Total Hip and Total Knee, Gait Abnormalities, and Outcomes Research

Recent Publications

Bozic KJ, Smith AR, Mauerhan DR. Pay-for-performance in orthopedics: implications for clinical practice. J Arthroplasty 2007; 22: 8-12. [PMID: 17823006]

Patt JC, Mauerhan DR. Outcomes research in total joint replacement: a critical review and commentary. Am J Orthop 2005; 34: 167-172. [PMID: 15913169]

Joshua Patt, MD

Joshua Patt, MD
Department of Orthopaedic Surgery
1616 Scott Avenue
Charlotte, N.C. 28203

Undergraduate School: Brown University
Medical School: Tulane University
Residency: Orthopaedic Surgery, Carolinas Medical Center
Fellowship: Musculoskeletal Oncology and Spine Surgery, University of Washington and Harborview Medical Center
Specialty: Musculoskeletal Oncology and Spine Surgery

Research Interests: Musculoskeletal Oncology and Spine Trauma and Reconstruction

Recent Publications

Biermann JS, Adkins D, Benjamin R, Brigman B, Chow W, Conrad EU 3rd, Frassica D, Frassica FJ, George S, Healey JH, Heck R Jr, Letson GD, Mayerson J, McGarry SV, O'Donnell RJ, Patt J, Randall RL, Santana V, Satcher RL, Schmidt RG, Siegel HJ, Wong MK, Yasko AW; National Comprehensive Cancer Network. Bone cancer. J Natl Compr Canc Netw 2007; 5: 420-437. [PMID: 17442233]

Kneisl JS, Patt JC, Johnson JC, Zuger JH. The utility of positron emission tomography (PET) with FDG in pediatric bone sarcomas. CORR 2006; 450: 101-104.

Gruber HE, Leslie K, Norton HJ, Heiner D, Patt J, Hanley EN Jr. Demographic factors that influence human disc cell proliferation in vitro. Spine J 2006; 6: 120-124. [PMID: 16517381]

Patt JC, Mauerhan DR. Outcomes research in total joint replacement: a critical review and commentary. Am J Orthop 2005; 34: 167-172. [PMID: 15913169]

Stephen Sims, MD

Stephen Sims, MD
Department of Orthopaedic Surgery
1616 Scott Avenue
Charlotte, N.C. 28203

Undergraduate School: Clemson University
Medical School: Medical University of South Carolina
Residency: Orthopaedic Surgery, Medical College of Virginia
Fellowship: Martin Allgower Trauma Fellowship
Specialty: Musculoskeletal Injury

Research Interests: Pelvic and Acetabular Fractures, Outcomes Research

Recent Publications

Sims SH. Subtrochanteric Femur Fracures. Stannard James P; Schmidt, Andrew H; Kregor, Phillip J. editor(s). 1st Edition. Surgical Treatment of Orthopaedic Trauma. New York:Thieme; pp. 589-610, 2007.

Karunakar MA, Sen A, Bosse MJ, Sims SH, Goulet JA, Kellam JF. Indometacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum. J Bone Joint Surg Br 2006; 88: 1613-1617. [PMID: 17159174]

Schaller TM, Sims S, Maxian T. Skin breakdown following circumferential pelvic antishock sheeting: a case report. J Orthop Trauma 2005; 19: 661-665. [PMID: 16247313]

Reilly, Norris, Bosse, Kellam, Sims: Pelvic Fractures: Sacral fixation In: Donald A. Wiss editor (s). 2nd Edition. Masters Technique in Orthopaedic Surgery Fracture. Philadelphia: Lippincott Williams and Wilkins; 669-684, 2006.

Bosse MJ, McCarthy ML, Jones AL, Webb LX, Sims SH, Sanders RW, MacKenzie EJ; The Lower Extremity Assessment Project (LEAP) Study Group. The insensate foot following severe lower extremity trauma: an indication for amputation? J Bone Joint Surg Am 2005; 87: 2601-2608. [PMID: 16322607]

 

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