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News and events will connect you to seminars, conferences, recent announcements and research activities related to Cannon Research Center and University of North Carolina at Charlotte.

CHS, Dr. Bonkovsky at forefront of groundbreaking research on acetaminophen

On Jan. 13, the Food and Drug Administration announced that they will begin limiting the amount of acetaminophen that can be found in prescription medications.

Acetaminophen, when taken at higher than recommended dosages, often unintentionally, has been linked to high incidence of liver damage and liver failure.

Acetaminophen is a common pain reliever and fever reducer sold under product names such as Tylenol®, NyQuil® and Excedrin® as well as prescription drugs such as Percocet and Vicodin.

Video courtesy of WCNC-TV, Charlotte
Read the entire story and watch the full interview with Dr. Bonkovsky at WCNC-TV.

Herbert Bonkovsky, MD, Senior Adviser for Research for the Liver-Biliary-Pancreatic Center at Carolinas HealthCare System, has been a leader in this groundbreaking research, much of that at Carolinas HealthCare System.

Carolinas Medical Center is a part of a large research effort on the issue.

It's only by doing carefully controlled and well-designed studies and putting a large number of patients together that we'll really be able to make progress and move the field forward," says Dr. Herbert Bonkovsky.

To participate in the research, contact Gale Groseclose at 704-355-4875 or email gale.groseclose@carolinashealthcare.org.

CMC Hosts International Workshop Focusing on Muscular Dystrophy Research
More than 50 internationally renowned scientists, researchers and clinicians attended the second International Workshop for Glycosylation Defects in Muscular Dystrophies hosted by Carolinas Medical Center last November.

Since the first workshop was held in 2008, numerous progresses have been made in different areas of muscular dystrophies associated with defects in alpha-dystroglycan (α-DG) glycosylation. The 2010 international workshop discussed the pathways responsible for the functional glycosylation of α-DG, the mechanisms underlying dystroglycanopathies, and the development of novel experimental therapy to the diseases.

The conference was sponsored by the Carolinas Medical Center with support from the Carolinas Muscular Dystrophy Research Endowment at the Carolinas HealthCare Foundation and the Muscular Dystrophy Association.

The workshop allows a rare opportunity to bring together internationally renowned scientists and clinicians with active research in these areas, providing them a unique opportunity to discuss the significance of recent progress, to facilitate collaboration, and finally to identify new approaches to treat the diseases.

Video: Herbert Bonkovsky, MD | Acute Porphyrias: Recognition Through Follow-Up
Video: Herbert Bonkovsky, MD | Acute Porphyrias: Recognition Through Follow-Up. A free account with MedscapeCME must be created in order to view the video.

Emergency Medicine Research's work highlighted on the cover of Physiological Genomics.
See Cover and Full Text.

Summer Student Scholars
The Cannon Research Center faculty mentored 24 summer students for the summer 2009. The students were exposed to a variety of research topics in addition to executing their own project which required a final poster presentation. Congratulations to our top three presenters:

  • 1st Place: Anne Lutin, ALS-related TDP-43 mRNA and Protein Expression in Human Blood Lymphocytes
  • 2nd Place: Laura Buchanan, The Relationship between Pregnancy-Associated Plasma Protein-A (PAPP-A) and Human Disc Degeneration
  • 3rd Place: Caryn Cloer, Triterpenoid saponins enhance the effect of AON-mediated exon skipping in dystrophic mdx mice

Kim Lang received an honorable mention with her presentation, Balance impairment in early ALS in the absence of clinical disability. She achieved notable success in her clinical setting.

Kirk Southern has the tremendous honor to present his work entitled Differential Expression of Osteopontin in Ovarian Carcinoma at the annual meeting of the Mid-Atlantic Gynecologic Oncology Society.

Students had the opportunity to network with many published scientists and evaluate their true desires for their future careers. For more information visit: CMC Summer Student Research Program

CHS Research Finds Long-Term Maintenance Therapy Ineffective in Non-Responsive Hepatitis C Patients
Carolinas HealthCare System researchers have found that long-term maintenance therapy with peginterferon does not reduce the rate of disease progression in Hepatitis C patients who failed to respond to standard therapy.

Herbert Bonkovsky, MD, Senior Adviser for Research for the Liver-Biliary-Pancreatic Center at Carolinas HealthCare System, published his findings in the Dec. 4 issue of the New England Journal of Medicine. His article, "Prolonged Therapy of Advanced Chronic Hepatitis C with Low-Dose Peginterferon," detailed his research. Read the full press release

CMC Discovery Holds Hope for MD Patients
A medical research team at Carolinas Medical Center (CMC), headed by Qi Long Lu, MD, PhD, has made a discovery that holds promise to restore muscle function in patients with Duchenne muscular dystrophy (DMD).

Dr. Lu's findings are summarized in an article that was published Sept. 30 in a highly respected research journal called "Proceedings of the National Academy of Sciences of the U.S.A." He and his colleagues have been utilizing a medical approach called "gene manipulation therapy" that - if ultimately proven safe and effective for humans - would offer new hope to DMD patients. >> Read the full press release

NEW! Dr. Qi Lu receives a major and prestigious grant from the National Institute of Health (NIH) for translating a highly promising novel therapy, exon skipping, into patient care of muscular dystrophy. See full story.

Cannon Center Research Seminar Series
Seminars in Clinical and Translational Research are held most Tuesdays between September-June from 12:30 - 1:30p.m. in the Cannon Research Auditorium at the Carolinas Medical Center. These seminars are designated as educational activities for a maximum of 1.0 AMA PRA Category 1 CreditTM.

Contact Information

Caren Anderson
Office of Research Administration
Cannon Research Center
704-355-9645 (Phone)

Bioinformatics Seminar Series at University of North Carolina at Charlotte
Seminars are hosted by UNC Charlotte Bioinformatics Research Center and the Charlotte Research Institute at 3:30 p.m. every Friday in Cameron 101, located on main campus of University of North Carolina, Charlotte.

For complete schedule, please go to http://www.bioinformatics.uncc.edu

Contact Information

Elise Marshall
Department of Bioinformatics and Genomics
University of North Carolina at Charlotte
Graduate Program Coordinator
College of Computing and Informatics
Cameron 216
704-687-7481 (Phone)

Farah Bahrani-Mougeot, PhD
Cannon Research Center
Carolinas Medical Center
Adjunct Graduate Faculty, University of North Carolina at Charlotte
704-355-8132 (Phone)

Biology Seminars at University of North Carolina at Charlotte
Seminars are hosted by UNC Charlotte Department of Biology and the Charlotte Research Institute at2p.m. every Friday in College of Education (COED) Room 010, located on main campus of University of North Carolina at Charlotte.

For complete schedule, please go to http://www.bioweb.uncc.edu/seminar/index.htm

Contact Information

Tracy Breslin
Department of Biology
University of North Carolina at Charlotte
704-687-8692 (Phone)

Farah Bahrani-Mougeot, PhD
Cannon Research Center
Carolinas Medical Center
Adjunct Graduate Faculty, University of North Carolina at Charlotte
704-355-8132 (Phone)

Liver-Biliary-Pancreatic Center Newsletters
The Liver-Biliary-Pancreatic Center of CMC has been established and is growing rapidly, both in terms of numbers of patients seen and cared for and in terms of the faculty members who make up the center. The Center is designed to provide the finest and best-coordinated evaluation and management possible for patients with disorders of the liver, bile ducts and pancreas. To learn more about recent activities of the Center and about currently active clinical studies that are open to new participants, please read the latest Newsletter of the Center (680KB, PDF).

 

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