Carolinas HealthCare System
In this Section

Marjan Mehrab-Mohseni

Marjan Mehrab-Mohseni, MSResearch Technician II
Liver Pathobiology Laboratory
Cannon Research Center
Carolinas HealthCare System 

Prior Positions and Experience

2013-present Research Technician II, Liver Pathobiology Laboratory, Carolinas Medical Center, Charlotte, NC
2008-2012 Research Technician II, Liver, Digestive and Metabolic Disorders Laboratory, Carolinas Medical Center, Charlotte, NC
2007-2008 Research Assistant, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
2004-2006 Research Assistant, Department of Virology, Swedish Institute for Infectious Diseases Control, Stockholm, Sweden
2002-2003 Research Technician, Research Center for Gastroenterology, and Liver Diseases, Tehran, Iran

Education

MS in Molecular Cell Biology; 2006-2007 Uppsala University, Sweden
BS in Applied Chemistry; 1995-2000 Tehran Azad University, Tehran, Iran

Marjan Mohseni has been working in the field of viral hepatitis for seven years. She joined in the Liver Group of the Research Center for Gastroenterology and Liver Diseases in Tehran, Iran, in 2002 working under the supervision of Professor Mohammad R. Zali. While in this lab, she worked on the molecular epidemiology of viral hepatitis.

Her collaboration with the Swedish Institute for Infectious Diseases Control led Marjan to carry on her research under the supervision of Professor Lars Magnius in late 2003. Marjan examined the molecular epidemiology of hepatitis B and assisted in the identification of a novel core promoter mutation in HBV isolates of Hepatitis B patients that was published in journal of General Virology. Marjan also worked on the molecular epidemiology of viral hepatitis A, C, and E while in Sweden as well as the complete genome sequencing of Enterovirus strains in a European multi-country project called Vizier.

Marjan's master thesis project involved the epigenetic reprogramming of host by CMV. She assisted in a collaborative project under supervision of Professor Tomas Ekstrom to identify DNMT1 translocation out of the cell by CMV transfection.

Since 2008, Marjan joined Liver, Digestive and Metabolic Disorders Laboratory when she explored the effects of a natural compound from Milk Thistle, Legalon-Sil on HCV replication under the guidance of Dr. Herbert Bonkovsky. Currently, Marjan is working in Liver Pathobiology Laboratory under the supervision of Dr. Laura Schrum, PhD, on identifying effects of Legalon-Sil on HCV entry into hepatocytes.

Recent Publications

Sendi H, Mehrab-Mohseni M. HFE Gene Mutations in Cryptogenic Cirrhosis Patients. Hepat Mon. 2012;12:48-9. [PMC: 3298877]

Esteki-Zadeh A, Karimi M, Strååt K, Ammerpohl O, Zeitelhofer M, Jagodic M, Mehrab-Mohseni M, Sjöholm L, Rahbar A, Söderberg-Nauclér C, Ekström TJ. Humancytomegalovirus infection is sensitive to the host cell DNA methylation state andalters global DNA methylation capacity. Epigenetics. 2012 Jun 1;7(6):585-93. [PMID: 22595877]

Mehrab-Mohseni M, Sendi H, Steuerwald N, Ghosh S, Schrum LW, Bonkovsky HL.Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressingfull-length HCV. World J Gastroenterol. 2011;17:1694-700. [PMID: 21483629]

Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM , Noorinaye B, Zali MR, Pumpens P, Bonkovsky HL, Magnius LO. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low viral load. J Clin Virol 2009; 46:259-264. [PMID: 19748824]

Sendi H, Mehrab-Mohseni M, Zali MR, Norder H, Magnius LO. T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D. J Gen Virol 2005; 86: 2451-8. [PMID: 16099903]

Selected Meeting and Abstract Presentations

Mehrab-Mohseni M, Sendi H, Schrum LW, Bonkovsky HL. Legalon-SIL down-regulates Occludin and Claudin expression in human liver cells expressing full length HCV genome. Hepatology: 54: 817A-817A, Suppl. 1, Oct 2011  

Sendi H, Mehrab-Mohseni M, Schrum LW, Bonkovsky HL. Mir-122 down-regulates OCLN expression through direct binding to the 3 ' UTR of OCLN mRNA . Heoatology 54: 1318A-1319A, Suppl. 1, Oct 2011

Mehrab-Mohseni M, Steuerwald N, Sendi H, Vachris J, Bonkovsky HL. Legalon-Sil down-regulates HCV core and NS5A expression in human hepatoma lines expressing full-length HCV. Hepatology 50: 685A-686A, 2009

Sendi H, Mehrab-Mohseni M, Steuerwald N, Bonkovsky HL. Heme Oxygenase 1 [HMOX1] expression is up-regulated by HCV in human hepatoma cells and is normalized through IFN treatment. Hepatology 50: 936A, 2009

Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM , Noorinaye B, Zali MR, Pumpens P, Bonkovsky HL, Magnius LO. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low viral load. Digestive Disease Week. Chicago 2009

Steuerwald N, Bennett K, Mehrab-Mohseni M, Sendi H, Bonkovsy HL. Global miRNA Expression Profile of HCV Infected Human Hepatoma Cells.  Digestive Disease Week. Chicago 2009

Karimi M, Mehrab-Mohseni M, Strat K, Soderberg-Naucler C, Ekstrom T. Epigenetic Reprogramming of host by Human Cytomegalovirus. KI Cancer. Stockholm, September 2007

Sendi H, Mehrab-Mohseni M, Zali MR, Norder H, Magnius LO. Mutations in core immune epitopes in different promoter and precore mutants in chronic e antigen negative hepatitis B. J Clinical Virol. 36: S82-S82  Suppl. 2, July 2006

About Carolinas HealthCare System
Who We Are
Leadership
Community Benefit
Corporate Financial Information
Diversity & Inclusion
Annual Report
Foundation
Patient Links
Pay Your Bill
Hospital Pre-Registration
Patient Rights
Privacy Policy
Financial Assistance
Quality & Value Reports
Insurance
Careers
Join Carolinas HealthCare System
Physician Careers

For Employees
Carolinas Connect
Connect with Us
Watch Carolinas HealthCare on YoutubeFollow Carolinas HealthCare on TwitterLike Carolinas HealthCare on FacebookContact Carolinas HealthCareJoin Carolinas HealthCare on LinkedInGo to our mobile website.