Carolinas HealthCare System
In this Section

Laura W. Schrum

Laura W. Schrum, PhD
Research Group Director, Liver Pathiobiology Laboratory
James G. Cannon Research Center

Prior Positions and Experience

2007-2009 Associate Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)
2001-2007 Assistant Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)
2000-2001 Research Assistant Professor, Department of Biology, University of North Carolina at Charlotte (Charlotte, NC)
1997-2000 Research Analyst, Department of General Surgery, University of North Carolina at Chapel Hill (Chapel Hill, NC)
1993-1997 Postdoctoral Fellow, NIH National Research Service Award, Department of Medicine, University of North Carolina at Chapel Hill (Chapel Hill, NC)

Education

BS (summa cum laude): 1988, North Carolina State University (Raleigh, NC)
PhD: 1993, North Carolina State University (Raleigh, NC)

Recent Publications

Karaa A*, Thompson KJ*, McKillop IH, Clemens MG, Schrum LW. 2008. S-Adenosyl-L-Methionine (SAMe) Attenuates Oxidative Stress and Hepatic Stellate Cell Activation in an Ethanol-Lipopolysaccharide (LPS)-Induced Fibrotic Rat Model. Shock. 30:197-205. [PMID: 18180699]
*Both authors contributed equally to this manuscript

Zheng J, Tian Q, Hou W, Watts JA, Schrum LW, Bonkovsky HL. 2008. Tissue-specific Expression of ALA Synthase-1 and Heme Oxygenase-1 and Their Expression in Livers of Rats Chronically Exposed to Ethanol. FEBS Lett. 582:1829-1834. [PMID: 18472004]

McKillop IH, Schrum LW. 2009. Role of Alcohol in Liver Carcinogenesis. Semin. Liver Dis. 29:222-232. [PMID: 19387921]

Son G, Hines IN, Lindquist J, Schrum LW, Rippe RA. 2009. Inhibition of Phosphatidylinositol 3-Kinase Signaling in Hepatic Stellate Cells Blocks the Progression of Hepatic Fibrosis. Hepatology. 50:1512-1523. [PMID: 19790269]

Brandon-Warner E, Sugg JA, Schrum LW, McKillop IH. 2010. Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in rat hepatocellular carcinoma cells. Cancer Lett. 291:120-129. [PMID: 19900758]

Lakner AM, Moore CC, Gulledge AA, Schrum LW. 2010. Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation. World J Gastroenterol. 16(40):5047-56. [PMCID: PMC2965281]

Lakner AM, Walling TL, McKillop IH, Schrum LW. Altered aquaporin expression and role in apoptosis during hepatic stellate cell activation. Liv. Int. 2011 Jan;31(1):42-51. [PMID: 20958918]

Day SA*, Lakner AM*, Moore CC, Yen MH, Clemens MG, Wu ES, Schrum LW.  2011. Opioid-like compound exerts anti-fibrotic activity via decreased hepatic stellate cell activation and inflammation. Biochem Pharmacol. 81:996-1003. [PMID: 21291870]
*Both authors contributed equally to this manuscript

Thompson KJ, Lakner AM, Cross BW, Tsukada S, Rippe RA, McKillop IH, Schrum LW. 2011. S-adenosyl-L-methionine inhibits collagen secretion in hepatic stellate cells via increased ubiquitination. Liver Int. 31:891-901. [PMID: 21645221]

Mehrab-Mohseni M, Sendi H, Steuerwald N, Ghosh S, Schrum LW, Bonkovsky HL. 2011. Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV. World J Gastroenterol. 17:1694-1700. [PMID: 21483629]

Tian Q, Li T, Hou W, Zheng J, Schrum LW, Bonkovsky HL. 2011. Lon Peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells. J. Biol. Chem. 286:26424-26430. [PMID: 21659532]

Moore CC, Lakner AM, Yengo CM and Schrum LW. 2011. Identification and function of nonmuscle myosin II isoforms in hepatic stellate cells. World J Hepatol. 3:184-197. [PMCID: PMC3158907]

Sokolov E, Schrum LW, McKillop IH. 2011. Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma. Cell Signal. 23:1603-1610. [PMID: 21620966]

Lakner AM, Bonkovsky HL, Schrum LW. 2011. microRNAs: fad or future of liver disease. World J Gastroenterol. 17:2536-2542. [PMID: 21633658]

Thompson KJ, McKillop IH, Schrum LW. 2011. Targeting collagen expression in alcoholic liver disease. World J Gastroenterol. 17:2473-2481. [PMCID: PMC3103805]

Ghosh S, Ahrens WA, Phatak SU, Hwang S, Schrum LW, Bonkovsky HL. 2011. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J Viral Hepat.18:e568-577. [PMID: 21914078]

Hwang SI, Lee YY, Park JO, Norton HJ, Clemens E, Schrum LW, Bonkovsky HL. 2011. Effects of a single dose of oral iron on hepcidin concentrations in human urine and serum analyzed by an improved LC-MS/MS method. Clinica Chemica Acta. 412:2241-2247. [PMID: 21867695]

Ellefson WM, Lakner AM, Hamilton A, McKillop IH, Bonkovsky HL, Steuerwald NM, Huet YM, Schrum LW. 2011. Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen.  PLoS ONE. 6(12):e29463. [PMID: 22206017]

Brandon-Warner E, Walling TL, Schrum LW, McKillop IH. 2012. Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis. Alcohol Clin Exp Res. 36:641-653. [PMID: 22017344]

Hou W, Tian Q, Steuerwald NM, Schrum LW, Bonkovsky HL. 2012. The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes. Biochim Biophys Acta. 1819:1113-1122. [PMID: 22698995]

Lakner AM, Steuerwald N, Walling T, Ghosh S, McKillop IH, Russo MW, Bonkovsky HB, Schrum LW. 2012. Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology. 56:300-310. [PMID: 22278637]

Osna N, Kharbanda K, Schrum L, Dolganiuc A. 2012. Advances in alcoholic liver disease. Int J Hepatol. 2012:563018. See article

Brandon-Warner E, Eheim AL, Foureau DM, Walling TL, Schrum LW, McKillop IH. 2012. Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice. Cancer Lett. 326:88-95. [PMID: 22863537]

Brandon-Warner E, Schrum LW, Schmidt CM, McKillop IH. 2012. Rodent models of alcoholic liver disease: Of mice and men. Alcohol. 46:715-725. [PMID: 22960051]

Lakner AM, Steuerwald NM, Schrum LW. 2013. Reply to HEP-12-0853.R3. Hepatology. 57:1286-1287. See article

Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL. 2013. Cytoskeletal proteins: shaping progression of hepatitis C virus-induced liver disease. Int Rev Cell Mol Biol. 302:279-319. [PMID: 23351713]

Bonkovsky HL, Hou W, Steuerwald N, Tian Q, Li T, Parsons J, Hamilton A, Hwang S, Schrum L. 2013. Heme status affects human hepatic messenger RNA and microRNAs expression. World J Gastroenterol. 19:1593-1601. [PMID: 23538684]

Current, Recent and Pending Grant Support

Current Funding
Funding Agency: Carolinas HealthCare System
Title: Tenascin-C as a therapeutic target and biomarker for obesity-induced HCC
Role: Co-Principal investigator (David Sindram)
Project Dates: 01/01/14-12/31/14
Goal: To delineate the cellular mechanism of tenascin-C in obesity-induced HCC.

Pending Funding
Funding Agency: NIH/NIAAA - R21
Title: Role of microRNAs in HSC-mediated fibrogenesis
Role: Principal investigator
Project Dates: 12/01/2013 - 11/30/2015
Goal: To determine the role of miR19b in HSC-mediated fibrosis and test this miR as an effective anti-fibrotic molecule.

Previous Funding
Funding Agency:NIH/NIAAA - R21 AA016858
Title:Effect of alcohol on hepatocellular carcinoma progression in vivo
Role: Co-Investigator (Iain McKillop, PI)
Project Dates:9/20/08 - 8/31/10
Goal: This project hypothesizes that the increased oxidative stress generated due to alcohol metabolism in the liver affects foci progression to HCC directly or via changes in the environment surrounding foci.

Funding Agency:Carolinas Medical Center
Title: Gender and sex steroid hormone effects on developmentally-induced responses in ALD
Role: Co-Principal Investigator (Nury Steuerwald, Yvette Huet, Co-PIs)
Project Dates:04/1/09 - 03/31/10
Goal: The specific goal of this proposal is to determine if the injurious effect of estrogen in alcohol-exposed females is due solely to adult exposure to estrogen or in part to the effects of estrogen on a female imprinted liver.

Funding Agency: NIH/NIAAA - R21 AA016858
Title: Effect of alcohol on hepatocellular carcinoma progression in vivo
Role: Co-Investigator (Iain McKillop, PI)
Project Dates:9/20/08 - 8/31/10
Goal: This project hypothesizes that the increased oxidative stress generated due to alcohol metabolism in the liver affects foci progression to HCC directly or via changes in the environment surrounding foci.

Funding Agency: Carolinas Medical Center
Title: Gender and sex steroid hormone effects on developmentally-induced responses in ALD
Role: Co-Principal Investigator (Nury Steuerwald, Yvette Huet, Co-PIs)
Project Dates:04/1/09 - 03/31/10
Goal: The specific goal of this proposal is to determine if the injurious effect of estrogen in alcohol-exposed females is due solely to adult exposure to estrogen or in part to the effects of estrogen on a female imprinted liver.

Funding Agency:Jenken Biosciences, Inc
Title:Studies of a Morphinan Derivative in the Inflammatory Injury Associated with Fatty Liver
Role: Co-PI (with Dr. Mark Clemens)
Project Dates: 07/01/2007 - 06/30/2008
Goal:The purpose of this project is to provide clear proof of concept regarding the ability of Nalmefene to ameliorate hepatic inflammation in a model and to elucidate the molecular mechanisms.

Funding Agency:NIH/NIDDK - R01 DK58503
Title:Engineering aspects of liver support systems.
Role:Co-Investigator (Mark Clemens, PI)
Project Dates: 9/30/01-7/31/06
Goal:To develop a partnership between bioengineers and biologists who will combine their expertise to improve bioartificial liver support systems and to improve liver preservation by using machine perfusion.

Funding Agency: NIH/NIDDK - R01 DK060606
Title: Prostanoids and liver microcirculation in stresses
Role: Co-Investigator (Jian Zhang, PI)
Project Dates:6/1/03 - 5/31/07
Goal: To evaluate the role of constrictor prostanoids in regulation of hepatic microcirculation in cirrhosis and endotoxin-induced sequential stresses.

Funding Agency: NIH/NIAAA - R03 AA14158
Title:Molecular mechanisms of SAMe in hepatic stellate cells
Role: Principal investigator
Project Dates: 9/30/02-8/31/05
Goal: To investigate the molecular mechanisms of the antioxidant S-adenosyl-L-methionine on the activation of NFkB and AP-1, and expression of TNFa, IL-6 and IL-10 in the hepatic stellate cell.

Funding Agency:NIH/NIAID - R01 AI053064
Title:Immunosuppression mediated by tick saliva protein Salp15
Role:Co-Investigator (Juan Anguita, PI)
Project Dates:7/1/03 - 6/30/07
Goal:This project is aimed to assess the mechanism of action of the tick saliva protein Salp15 on CD4+ T cells and the identification and characterization of its receptor.

Funding Agency:NIH - National Research Service Award
Title:Signal transduction in hepatic stellate cells initiated by TGFb1
Role:Principal Investigator
Project Dates:1994-1997
Goal:To characterize the signal transduction pathway(s) of TGFb1 in primary rat hepatic stellate cells.

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