Jean-Luc Mougeot, PhD
Computational Biology Research
Department of Oral Medicine
Professor and Associate Graduate Faculty, University of North Carolina at Charlotte
Prior Positions and Experience
||Research Director, Translational Genomics/ Computational Biology Research, Department of Oral Medicine, Carolinas Medical Center and Adjunct Professor, UNC-Charlotte (Charlotte, NC)
||Director, Scientific Development, Department of Therapeutic Research and Development, Carolinas HealthCare System and Adjunct Professor, UNC-Charlotte (Charlotte, NC)
||Senior Scientist, Molecular Biologist, Cannon Research Center, Carolinas Medical Center and Adjunct Professor, UNC-Charlotte (Charlotte, NC)
||Consultant, Computational Biology/ Bioinformatics, Carolinas Medical Center (Charlotte, NC)
||Senior Research Scientist / Director, Protein Expression Core Laboratory, deCODE Genetics, Inc. (Reykjavik, Iceland)
||Senior Research Fellow, Laboratory of Molecular Biology, Medical Research Council (Cambridge, United Kingdom)
||Consultant, Biotech Marketing, European Center for Management (Colmar, France); Novartis International AG (Basle, Switzerland); and University of Freiburg (Freiburg, Germany)
PhD: 1995, University Louis Pasteur (Strasbourg, France)
Dr. Mougeot has a broad research background in gene regulation and molecular mechanisms of pathogenesis in various diseases affecting plants (e.g., pararetroviral infections) and humans (e.g., ovarian cancer, mucositis, schizophrenia, multiple sclerosis, and amyotrophic lateral sclerosis). In addition, during the recent years, Dr. Mougeot has conducted several genome-wide expression profiling studies and used a diverse array of bioinformatics and computational systems biology tools for data analysis. His expertise in computational biology has led to the design of new research strategies or approaches in functional genomics/ proteomics towards improvement or development of diagnosis, prognosis, and therapy. Dr. Mougeot has recently joined the Department of Oral Medicine to dedicate his efforts to the study of diseases such as cancer therapy-induced oral mucositis, head and neck cancer, Sjögren’s syndrome, and infective endocarditis.
Molecular Virology Research
Mougeot JL, Guidasci T, Wurch T, Lebeurier G, Mesnard JM. Identification of C-terminal amino acid residues of cauliflower mosaic virus open reading frame III protein responsible for its DNA binding activity. Proc Natl Acad Sci U S A. 1993;90(4): pp1470-3. PMCID: PMC45895
Leclerc D, Burri L, Kajava AV, Mougeot JL, Hess D, Lustig A, Kleemann G, Hohn T. The open reading frame III product of cauliflower mosaic virus forms a tetramer through a N-terminal coiled-coil. J Biol Chem. 1998;273(44): 29015-21. PMID: 9786907
Genome and Transcriptove Computational Biology/ Bioinformatics Research
Cancer/ Oral Mucositis
Marshburn PB, Zhang J, Bahrani-Mostafavi Z, Mostafavi BZ., Marroum MC, Mougeot JL, Roshon MJ. Estrogen receptor-alpha mRNA variants lacking exon 5 or exon 7 are co-expressed with wild type form during all stages of human endometrial development. Am J Obstet Gynecol. 2004;191(2):633-4. PMID: 15343251
Mougeot JL, Bahrani-Mostafavi Z, Vachris JC, McKinney KQ, Gurlov S, Naumann RW, Higgins RV, Hall BJ. Gene expression profiling of ovarian tissues for determination of molecular pathways reflective of tumorigenesis. J Mol Biol. 2006;358(1):310-29. PMID: 16503337
Brennan MT, Coleman S, Kent ML, Lockhart PB, Bahrani-Mougeot F, Mougeot JL. Gene expression profiling of buccal mucosa specimens from patients with acute myelogenous leukemia exposed to chemotherapy. J Clin Oncol. 2005;23: (16S).
Mougeot JL, Bahrani-Mougeot F, Lockhart PB, Brennan MT. Microarray analyses of oral punch-biopsies from AML patients suggest immune deregulation and DNA damage as a likely prerequisite for chemotherapy-induced oral mucositis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(4):446-52. PMID: 21862359
Mougeot JL, Mougeot FK, Padilla RJ, Brennan MT, Lockhart PB. Use of archived biopsy specimens to study gene expression in oral mucosa from chemotherapy-treated cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(5):630-7. PMID: 23541936
Lee JG, McKinney KQ, Mougeot JL, Bonkovsky HL, Hwang S. Proteomic strategy for probing complementary lethality of kinase inhibitors against pancreatic cancer. Proteomics. 2013;13(23-24):3554-62. PMID: 24167056
Infection Control and Microbiome Metagenomics
Napeñas JJ, Brennan MT, Coleman S, Kent ML, Noll J, Frenette G, Nussbaum ML, Mougeot JL, Paster BJ, Lockhart PB, Bahrani-Mougeot FK. Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(4):554-60. PMID: 20303053
Bahrani-Mougeot FK, Strader W, Mougeot JL, Lovell R. Incidence of Klebsiella pneumoniae Carbapenemase (KPC)-producing Multidrug-Resistant Bacterial Infections in a Teaching Hospital in SouthEast. Am J Infect Control. 2012;40(5):e65. doi:10.1016/j.ajic.2012.04.114
Mougeot JL, Mougeot FB, Stevens CB, Kokaras AS, Morton D, Brennan MT, Paster B, Lockhart PB. Microbiome Analysis of Subgingival Plaque in Bacteremic Patients. J Dental Res. 2014;93(B).
Mougeot FB, Mougeot JL, Stevens CB, Kokaras AS, Morton D, Brennan MT, Paster BJ, Lockhart PB. Effects of Antibiotic Prophylaxis on Microbial Community of Dental Plaque. J Dental Res. 2014;93(B).
Mougeot JL, Bonkovsky HL, Brooks BR. Genetic polymorphisms in ALS revisited: a systems biology approach. Amyotroph Lateral Sc. 2008;9(S1):97.
Mougeot JL, Milazi-Richardson S, Brooks BR. Whole-genome association studies of sporadic amyotrophic lateral sclerosis: are retroelements involved? Trends Mol Med. 2009;15(4):148-58. (Bioinformatics meta-analysis) PMID: 19332388
Mougeot JL, Li Z, Price AE, Wright FA, Brooks BR. Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway. BMC Medical Genomics. 2011;4:74. doi:10.1186/1755-8794-4-74
Baciu C, Thompson KJ, Mougeot JL, Brooks BR, Weller JW. The LO-BaFL method and ALS microarray expression analysis. BMC Bioinformatics. 2012;13:244. doi: 10.1186/1471-2105-13-244
Mougeot JL, Price AE, Ghosh S, Lutin AC, Hemendinger RA, Armstrong III EJ, Brooks BR. Confocal microscopy analysis of altered TDP-43 expression in peripheral blood lymphocytes from ALS patients (2012). Amyotroph Lateral Sc. 2012;13(S1):59-72.
Mougeot JL, Ghosh S, Lutin AC, Price AE, Hemendinger RA, Armstrong III EJ, Brooks BR. Confocal microscopy analysis of altered TDP-43 expression in peripheral blood lymphocytes from ALS patients. Annals of Neurology, 137th Annual Meeting of the American Neurological Association. 2012; 72(16): S1-S232, A3-A8.
Niemeier JP, Mougeot JL, Hurst B, Grafton L. Effects of endogenous reproductive hormones fluctuations in TBI short-term recovery. ACRM 90th Annual Meeting. Archives of Physical Medicine and Rehabilitation. 2013.
Perrin PB, Niemeier JP, Mougeot JL, Vannoy CH, Hirsch MA, Watts JA, Rossman W, Grafton LM, Guerrier TD, Pershad R, Kingsbury CA, Bartel SW, Whitney MP. Measures of Injury Severity and Prediction of Acute Traumatic Brain Injury Outcomes. J Head Trauma Rehabil. 2014 Feb 28. [Epub ahead of print] PMID: 24590151
Gruber HE, Mougeot JL, Hoelscher G, Ingram JA, Hanley EN. Microarray analysis of laser capture microdissected-annulus cells from the human intervertebral disc. Spine. 2007;32(11):1181-87. PMID: 17495774
Stem cell biology and drug studies
Neural stem cell differentiation
Milazi-Richardson S, Brooks BR, Mougeot JL (senior author). Enrichment of motor neuron-like cell precursor derived from mouse embryonic stem cells by density gradient centrifugation. Acta Neuropharmacologica. 2011;1(1):16-25.
Motor neuron cell survival
Hemendinger RA, Armstrong III EJ, Persinski R, Todd J, Mougeot JL, Panov A, Volvovitz F, Rosenfeld J. Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death. Neurotox Res. 2008; 13: pp49-62. PMID: 18367440
Current, Recent and Pending Grant Support
Research Grant Award from the North Carolina Translational and Clinical Science Research Institute (NC-TRACS)
ALS Foundation Research Fund
Freedland Foundation Cancer Research Grants
Carolinas HealthCare System Research Grants
Sonia Hanko Wyatt Ovarian Cancer Foundation Grant