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Hossein Sendi

Hossein Sendi, MD, PhD
Post-doctoral Research Fellow
The Liver-Biliary-Pancreatic Center
Carolinas Medical Center

Prior Positions and Experience

2013-present Post-doctoral Research Fellow, The Liver-Biliary-Pancreatic center, Carolinas Medical Center, Charlotte, NC
2008-2012 Research Assistant, Liver & Digestive Diseases Laboratory, Carolinas Medical Center,
Charlotte, NC
2004-2006 Research Assistant, Department of Virology, Swedish Institute for Infectious Diseases Control, Stockholm, Sweden
2002-2003 Research Associate, Research Center for Gastroenterology, and Liver Diseases, Tehran, Iran
2000-2001 General practitioner, Tehran, Iran

Education

MD, Doctorate in Medicine; 1992-1999 Tehran University of Medical Sciences, Tehran, Iran
MPhil, Licenciate in Infection Biology; 2004-2006, Microbiology and Tumor Biology Department, Karolinska Institute, Stockholm, Sweden
PhD, 2008-2012; Department of Biology, University of North Carolina, Charlotte, NC

Hossein (Shahin) Sendi received his Doctorate Degree in Medicine (MD) in 1999 from Tehran University of Medical Sciences, Tehran, Iran. He practiced medicine as a general practitioner in Tehran, Iran during 2000-2001. In 2002, he joined Research Center for Gastroenterology and Liver Disease (RCGLD), Teharn, Iran as a clinical investigator working in the field of viral Hepatitis. Since Nov 2003, Shahin continued his research in Swedish Institute for Infectious Disease, Stockholm, Sweden, which led to a Licentiate (MPhil) degree in Infection Biology from Karolinska Institute, Sweden in 2006. His thesis was to identify viral and host determinants in Hepatitis B. His work in Sweden led to the identification of a novel core promoter mutation in the isolates of HBV infected patients. Dr. Sendi  received his PhD in Biology in 2013  from University of North Carolina at Charlotte under the guidance of Dr. Herbert Bonkovsky and Dr. Mark Clemens, working on molecular pathogenesis of Hepatitis C Virus. His thesis dealt with the role of miR-122 in HCV pathogenesis. Dr. Sendi is  currently a post-doctoral research fellow working at the Liver-Biliay-Pancreatic center under the direction of Dr. Herbert Bonkovsky. He is investigating the role of miRNAs in molecular pathogenesis of HCV both with in vitro studies and translational research on patients with chronic hepatitis C.

Selected Peer-reviewed Publications

Sendi H, Ghaziani T, Zali MR, Adibi P, Agah M, Jazayeri M, Shahraz S, Magnius L, Bonkovsky HL. Hemochromatosis mutations in Iranians with hepatitis B virus infection. Clin Infect Dis. 2005;40:e19-21. PMID: 15668853

Sendi H, Mehrab-Mohseni M, Zali MR, Norder H, Magnius LO. T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D.J Gen Virol. 2005;86:2451-8. PMID: 16099903

Ghaziani T, Alavian SM, Zali MR, Shahraz S, Agah M, Jensen KP, Ansari S, Sendi H, Lambrecht RW, Covault J, Bonkovsky HL. Serum Measures of Iron Status and HFE Gene Mutations in Patients with Chronic Hepatitis B. Hepatol Res. 2007; 37:172-8. PMID: 17362299

Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM , Noorinaye B, Zali MR, Pumpens P, Bonkovsky HL, Magnius LO. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low viral load. J Clin Virol. 2009; 46:259-264. PMID: 19748824

Narang TK, Sendi H, Scobey M, Bonkovsky HL. Iron and hepatitis C. Current Hepatitis Reports. 2010;9:169-177. DOI: 10.1007/s11901-010-0049-z
Alidoust L, Zafarghandi M, Agah M, Sendi H, Alavian SM, Zali MR. Glutathione-S-transferase M1, T1 and P1 gene polymorphisms in type I autoimmune hepatitis: a case-control study. Indian J Gastroenterol. 2007;26: 97-9. [PMID: 17558082]

Mehrab-Mohseni M., Sendi H., Steuerwald N., Ghosh S., Schrum L.W., Bonkovsky H.L.  2011.  Legalon-SIL down-regulates HCV core and NS5A in human hepatocytes expressing full-length HCV. World J. Gastroenterol.  17:1694-700. [PMID: 21483629]

Sendi H, Mehrab-Mohseni M. HFE gene mutations in cryptogenic cirrhosis patients. Hepat Mon. 2012;12:48-9. [PMCID: PMC3298877]

Assar S, Arababadi MK, Mohit M, Ahmadabadi BN, Pumpens P, Khorramdelazad H, Hajghani M, Assar S, Araste M, Nekhei Z, Sendi H, Kennedy D. T helper and B cell escape mutations within the HBc gene in patients with asymptomatic HBV infection: a study from the South-Eastern region of Iran. Clin Lab. 2012;58:53-60. [PMID: 22372345]

Caballes FR, Sendi H, Bonkovsky HL. Hepatitis C, porphyria cutanea tarda and liver iron: an update. Liver International. 2012;32:880-93. [PMID: 22510500]

Sendi H. Dual Role of miR-122 in molecular pathogenesis of viral hepatitis. Hepat Mon. 2012;12:312-4. [PMID: 22783341]

Khorramdelazad H, Hakimizadeh H, Hassanshahi G,  Rezayati M, Sendi H, Kazemi Arababadi M. CCR5 D 32 mutation is not prevalent in Iranians with chronic HBV infection. J Med Virol.  2013;85:964-8. [PMID:23588722]

Selected Peer-reviewed Abstracts and Presentations

Sendi H, Mehrab-Mohseni M, Schrum LW, Bonkovsky HL. Mir-122 down-regulates OCLN expression through direct binding to the 3 ' UTR of OCLN mRNA . Heoatology 54: 1318A-1319A, Suppl. 1, Oct 2011

Mehrab-Mohseni M, Sendi H, Schrum LW, Bonkovsky HL. Legalon-SIL down-regulates Occludin and Claudin expression in human liver cells expressing full length HCV genome. Hepatology: 54: 817A-817A, Suppl. 1, Oct 2011

Sendi H, Mehrab-Mohseni M, Steuerwald N, Bonkovsky HL. Heme Oxygenase 1 [HMOX1] expression is up-regulated by HCV in human hepatoma cells and is normalized through IFN treatment. Hepatology 50: 936A, Oct 2009

Sendi H, Mehrab-Mohseni M, Shahraz S, Norder H, Alavian SM , Noorinaye B, Zali MR, Pumpens P, Bonkovsky HL, Magnius LO. CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low viral load. Gastroenterology 136(5): A865-A865 Suppl. 1, Nov 2009  

Mehrab-Mohseni M, Steuerwald N, Sendi H, Vachris J, Bonkovsky HL. Legalon-Sil down-regulates HCV core and NS5A expression in human hepatoma lines expressing full-length HCV. Hepatology 50: 685A-686A, Oct 2009

Steuerwald N, Bennett K, Mehrab-Mohseni M, Sendi H, Bonkovsy HL. Global miRNA Expression Profile of HCV Infected Human Hepatoma Cells.  Gastroenterology 136(5): A842-A842 Suppl. 1, 2009  

Zhang L, Steuerwald N, Wang G, Hou W, Sendi H, Tian Q, Bonkovsky HL. Traditional Chinese medicines (TCM) for chronic hepatitis C (CHC) in China: Review of randomized controlled trailas. 13th International Symposium on Viral Hepatitis and Liver Disease. Washington DC 2009

Zhang L, Hou W, Wang G, Steuerwald N, , Sendi H, Tian Q, Bonkovsky HL. Randomized controlled trials of traditional Chinese medicine (TCM) for chronic hepatitis B (CHB) IN China. 13th International Symposium on Viral Hepatitis and Liver Disease. Washington DC 2009

Sendi H, Mehrab-Mohseni M, Zali MR, Norder H, Magnius LO. Mutations in core immune epitopes in different promoter and precore mutants in chronic e antigen negative hepatitis B. J Clinical Virol. 36:     S82-S82  Suppl. 2, July 2006 
Alidoust L, Agah M, Sendi H, et al. Association of Glutathion-S-Transferase m1, t1 and p1 gene Polymorphisms with autoimmune hepatitis (AIH) in Iranian population. Gastroenterology 128 (4): A728-A728 Suppl. 2, Apr 2005

Esteghamat F, Ghaziani T, Sendi H, et al. HLA DRB1*04 in autoimmune hepatitis patients-frequency and relationship with response to treatment. Gastroenterology 128 (4): A728-A728 Suppl. 2, Apr 2005

Esteghamat F, Ghaziani T, Sendi H, et al.  HLA DRBl *04 alleles in autoimmune hepatitis patients frequency and   relationship with response to treatment . European conference of human genetic, Prague, 2005.

Agah M, Motahari Z, Zafarghandi M, Sendi H, et al. Hemochromatosis and transferrin receptor-2 gene mutations in Iranian patients with chronic hepatitis C. Am J Gastrol 100 (9): S130-S130 324 Suppl. S Sep 2005

Ghaziani T, Sendi H, Javeri A, et al.  Human papillomavirus-16 and-18 DNA and Epstein-Bar virus DNA in esophageal squamous cell carcinoma. Gastroenterology 126 (4): A652-A652 Suppl. 2, Apr 2004

Rezailashkajani M, Roshandel D, Hekmatdoost A, Shalmani HM, Ghaziani T, Sendi H, et al. Clinical and laboratory characteristics of autoimmune hepatitis in 46 Iranian patients. Am J Gastrol 99 (10): S88-S88 270 Suppl. S, Oct 2004

Sendi H, Ghaziani T, Adibi P, et al. Distribution of HFE gene mutations in HBs Ag positive patients. Gastroenterology 124 (4): A725-A725 Suppl. S, Apr 2003

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