Farah K. B. Mougeot, PhD

Farah K. Bahrani Mougeot, PhD

Senior Scientist and Director, Microbiome Research
Oral Medicine Research Laboratory
Carolinas Medical Center
Associate Professor and Associate Graduate Faculty, University of North Carolina at Charlotte

Prior Positions and Experience

2012-  

Senior Scientist, Director, Microbiome Research- Oral Medicine Research Laboratory, Carolinas Medical Center (Charlotte, NC)

2007-2012

Molecular Microbiology Scientist, LBP, Cannon Research Center, Carolinas Medical Center (Charlotte, NC)

2002-2007

Senior Scientist, Director, Oral Medicine Research Laboratory, Carolinas Medical   Center (Charlotte, NC)

200-2002

Senior Scientist/ Group leader, Prokaria, Ltd. (Reykjavik, Iceland)

1999-2000

NIAID/National research Service Award (NRSA)   Fellowship in Vaccinology (Bethesda, MD)

1998

Certificate in Epidemiology of Pediatric Infectious Diseases, WHO (Geneva,         Switzerland)

1997-2000

Research Fellow/   Bacterial Pathogenesis, Division of Infectious Diseases & Center for Vaccine Development, University of Maryland (Baltimore, MD)

1995-1996

European Molecular Biology Organization   (EMBO) Fellowship in Cellular Microbiology (Heidelberg, Germany)

1995-1997

Postdoctoral Fellow, Pathogen-Host   Interaction, Pasteur Institute   (Paris, France)

1989-1995

Research Assistant and Postdoctoral Fellow/   Bacterial Pathogenesis, School of Medicine, University of Maryland   (Baltimore, Maryland)

1987-1989

Research   and Teaching Assistant, University of North Carolina at Charlotte (Charlotte,   NC)

Education

PhD: 1994  School of Medicine, University of Maryland (Baltimore, MD)

Research Interests

For over 27 years, Dr. Mougeot’s research has revolved around understanding of the mechanisms of pathogenesis of bacteria in infectious diseases. The results of some of her previous studies have laid the groundwork for ongoing vaccine development against common uropathogens including Proteus mirabilis and uropathogenic E. coli, the design of anti-pathogenicity molecules against the enteric bacterial pathogens such as Shigella flexneri, the identification of diverse and novel bacterial pathogens involved in systemic infections such as pneumonia caused by the bacterial colonizers of the oral cavity, and characterization of the bacteremia following dental procedures.

Using molecular-based strategies, Dr. Mougeot studies the bacteria involved in disease in their human niche. Her current work at the Department of Oral Medicine at Carolinas Medical Center (CMC) includes the characterization of the oral microbiome and the host factors and their impact in various diseases such as cancer, cardiovascular disease, and mucositis following chemotherapy. 

Dr. Mougeot has also been involved in epidemiological studies of health care associated infections caused by Clostridium difficile and carbapenemase producing Enterobacteriaceae in collaboration with Departments of Infection Control and Internal Medicine/ Division of Gastroenterology at CMC.

Read more about Oral Medicine Research.

Selected Publications and Book Chapters

Hobel CF, Hreggvidsson GO, Marteinsson VT, Bahrani-Mougeot FK, Einarsson FM, Kristjansson JK. Cloning, expression and characterization of a highly thermostable family of chitinase from Rhodothermus marinus. Extremophiles. 2005; 9(1):53-64. DOI: 10.1007/s00792-004-0422-3. [PMID: 15583965]

Brigisson H, Fridjonsson O, Bahrani-Mougeot FK, Hreggvidsson GO, Kristjansson JK, Mattiasson BO. A new thermostable a-L-arabinofuranosidase from a novel thermophilic bacterium.  Extremophiles.  Biotech Let. 2004; 26(17):1347.

Buckles EL, Bahrani-Mougeot FK, Molina A, Lockatell CV, Johnson DE, Drachenberg CB, Burland V, Blattner FR, Donnenberg MS.  Identification and characterization of a novel uropathogenic Escherichia coli-Associated fimbrial Gene cluster.  Infect Immun. 2004; 72(7):3890-901. [PMID: 15213132]

Bahrani-Mougeot FK, Buckles EL, Lockatell CV, Hebel JR, Johnson DE, Tang CM, Donnenberg MS. Type 1 fimbriae and extracellular polysaccharides are preeminent uropathogenic Escherichia coli virulence determinants in the murine urinary tract.  Mol Microbiol. 2002; 45(4):1079-93. [PMID: 12180926]

Bahrani-Mougeot FK, Gunther NW IV, Donnenberg MS, Mobley HLT.  UropathogenicE. coli. p. 239-68. In Donnenberg M.S., ed. Escherichia coli:  Virulence mechanisms of a versatile pathogen.  Academic Press (2002)

Brennan MT, Bahrani-Mougeot FK, Fox PC, Kennedy TP, Hopkins S, Boucher RC, Lockhart PB. The Role of Oral Microbial Colonization in Ventilator-Associated Pneumonia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 98(6):665-72. [PMID: 15583538]

Brennan MT, Coleman S, Kent ML, Lockhart PB, Bahrani-Mougeot F, Mougeot JL. Gene expression profiling of buccal mucosa specimens from patients with acute myelogenous leukemia exposed to chemotherapy. J Clin Oncol. 2005; 23(16S).

Napeñas JJ, Brennan MT, Bahrani-Mougeot FK, Fox PC, Lockhart PB. Relationship Between Mucositis and Changes in Oral Microflora during Cancer Chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103(1):48-59. [PMID: 17178494]

Bahrani-Mougeot FK., Paster BJ, Coleman S, Barbuto S, Brennan MT, Noll J, Kennedy T, Fox PC, Lockhart PB. Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia. J Clin Microbiol. 2007;45(5): 1588-93. [PMCID: PMC1865865]

Lockhart PB, Brennan MT, Sasser H, Noll J, Coleman S, Ashar J, Kent ML, Fox PC, Paster BJ, Bahrani-Mougeot FK. Tooth extraction and tooth brushing both produce bacteremia of endocarditis-related pathogens. J Am Coll Cardiol. 2007; 49(9 supplA):301A.

Bahrani-Mougeot FK, Paster BJ, Coleman S, Ashar J, Knost, S, Sautter, RL, Lockhart, PB. Identification of oral bacteria in blood cultures by conventional versus molecular methods. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 105(6): 720-4. [PMID: 18485308]

Bahrani-Mougeot FK, Paster BJ, Coleman S, Asher J, Barbuto S, Lockhart PB. Diverse and novel oral bacterial species in blood following dental procedures. J Clin Microbiol. 2008; 46 (6):2129-32. [PMCID: PMC2446827]

Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Bacteremia associated with tooth brushing and dental extraction. Circulation 2008; 117(24):3118-25. [PMCID: PMC2746717]

Bahrani-Mougeot FK, Thornhill M, Sasser H, Marriott I, Brennan MT, Papagerakis S, Coleman S, Fox PC, Lockhart PB. Systemic host immuno-inflammatory response to dental extractions and periodontitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106(4):534-41. [PMID: 18619871]

Lockhart PB, Brennan MT, Sasser HC, Fox PC, Paster BJ, Bahrani-Mougeot FK. Response to letter by Kaplan Regarding Article, “Bacteremia associated with tooth brushing and dental extraction.” Circulation 2009; 119(2): e14.

Bahrani-Mougeot FK, Scobey, MW, Sansonetti, PJ. Enteropathogenic infections. In Encyclopedia of Microbiology (Schaechter M ed). Academic Press. Oxford 2009

Lockhart PB, Brennan MT, Thornhill M, Michalowicz B, Noll J, Bahrani-Mougeot FK, Sasser HC. Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. J Am Dent Assoc. 2009; 140(10): 1238-44. [PMCID: PMC2770162]

Napeñas JJ, Brennan MT, Coleman S, Kent, ML, Noll, J, Frenette G, Fox PC, Mougeot, J-L, Paster BJ, Lockhart PB, and Bahrani-Mougeot FK. Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(4): 554-60. [PMID: 20303053]

Xu XD, Zhang YC, Gao P, Bahrani-Mougeot FK, Zhang LY, He ZY, Zhang YW, Ma JZ. Treatment of major laparoscopic bile duct injury: A long-term follow-up result. Am Surg. 2011;77(12): 1584-8. [PMID: 22273213]

Mougeot JL, Bahrani-Mougeot FK, Lockhart PB, Brennan MT. Microarray analyses of oral punch-biopsies from acute myeloid leukemia (AML) patients treated with chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(4): 446-52. [PMID: 21862359]

Bahrani-Mougeot F, Strader W, Mougeot, JL, Lovell R. Incidence of Klebsiella pneumoniae carbapenemase (KPC)-producing multidrug-resistant bacterial infections in a teaching hospital in southeast. Am J Infect Control. 2012;40(5): e65.

Mougeot JL, Mougeot F, Padilla RJ, Brennan MT, Lockhart PB. Use of archived biopsy specimens to study gene expression in oral mucosa from chemotherapy-treated cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(5):630-7. [PMID: 23541936]

Hanna EM, Hamp T, McKillop IH, Bahrani-Mougeot FK, Martinie JB, Horton JM, Sindram D, Gharaibeh RZ, Fodor AA, Iannitti DA. Comparison of culture and molecular techniques for microbial community characterization in infected necrotizing pancreatitis. J Surg Res. 2014;191(2):362-9. doi:10.1016/j.jss.2014.05.003

Research Grant Support

Grant Title: Oral Hygiene, Periodontal Disease, and Infective Endocarditis
Funding Agency: NIDCR
Grant #: R01-DE023375-01A1
Role: Co- Investigator (PI: Peter Lockhart)
Project dates: 09/2014 to 08/2019

Grant Title: Oral mucositis following chemotherapy and radiotherapy in cancer patients at Carolinas Medical Center
Funding Agency: Charlotte Freedland Foundation
Role: Co- Investigator
Project dates: 2009-present

Grant Title: Molecular analysis of bacterial species in an animal model of alcohol induced, infected necrotizing pancreatitis – A pilot study
Funding Agency: Education and Research Grant, Carolinas HealthCare System
Role: Co-Investigator
Project dates: 2011-2013

Grant Title: Determination of the microbial etiology of spontaneous bacterial peritonitis using a molecular approach.
Funding Agency: American College of Gastroenterology (ACG) (Clinical Research Grant)
Role: Principal investigator
Project dates: 2008-2010

Grant Title: Microbial etiology of spontaneous bacterial peritonitis in patients with advanced liver disease.
Funding Agency: Carolinas HealthCare System (Education and Research Grant)
Role: Principal Investigator
Project dates: 2008-2010

Grant Title: Determining the cause of oral mucositis following chemotherapy for cancer: Molecular analysis of a unique archive of oral mucosal tissues from cancer patients who underwent chemotherapy
Funding Agency: Charlotte Freedland Foundation
Role: Co- Investigator
Project dates: 2008-2009

Grant Title: Viability of clinically important aerobic bacteria using different swab transport systems
Funding Agency: Copan Diagnostics Inc.
Role: Principal Investigator
Project dates: 2007

Grant Title: Determining the cause of oral mucositis following chemotherapy for cancer: Molecular analysis of a unique archive of oral mucosal tissues from cancer patients who underwent chemotherapy
Funding Agency: Charlotte Freedland Foundation
Role: Co-Investigator
Project dates: 2006-2007

Grant Title: Biological validation of differential Gene expression in buccal mucosal specimens of acute myelogenous leukemia patients exposed to chemotherapy
Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc.
Grant #: 204-155
Role: Co-Investigator
Project dates: 2006-2007

Grant Title: Immune alterations associated with bacteremia from dental procedures
Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc.
Grant #: 201-287       
Role: Co-Investigator
Project dates: 2005-2006

Grant Title: Changes in oral flora in patients undergoing cancer chemotherapy
Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc.
Grant #: 201-254
Role: Co-Investigator
Project dates: 2004-2008

Grant Title: Role of Oral Bacteria in Ventilator-Associated Pneumonia (VAP)
Funding Agency: The Charlotte-Mecklenburg Health Services Foundation, Inc. (#201179)
Role: Principal Investigator
Project dates: 2003-2007

Grant Title: Relationship between baseline tissue mRNA expression and chemotherapy induced mucositis
Funding Agency: Charlotte-Mecklenburg Health Services Foundation, Inc.
Grant #: 200-998
Role: Co-Investigator
Project dates: 2002-2005

Grant Title: Bacteremia from Dental Extractions vs. Oral Hygiene
Funding Agency: NIH/ NIDCR
Grant #: R01-DE13559-01A2
Role: Co- Investigator (PI: Peter Lockhart)
Project dates: 05/2002 to 04/2006

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