The Emergency Medicine Research Laboratory conducts translational research focused primarily on pulmonary embolism. There is cooperation and synergy created from the interaction between clinical and basic science studies. Specialized analyses are conducted on patient samples. Animal models provide evidence for new diagnostic markers, mechanisms of disease progression and novel treatments. These types of information are then used to generate hypotheses for clinical studies or devices for diagnosis. Recent animal studies focus upon the hypothesis that inflammation results in a biphasic response, contributing to both right ventricle damage and healing from pulmonary embolism. Right ventricular damage is associated with a dramatic increase in mortality and morbidity in patients with pulmonary embolism. We hope to provide protection of the heart during the pulmonary embolism to enhance the subsequent quality of life in these patients. Additional animal studies focus upon the hypothesis that pulmonary arterial endothelial dysfunction contributes to limited blood flow through the lungs during pulmonary embolism. We hope to enhance blood flow and gas exchange by protecting endothelial function during pulmonary embolism.
Mission Statement: To research the mechanisms and treatment of acute, life-threatening diseases and injury.
Jeffrey A. Kline, MD, Director of Emergency Medicine Research
John A. Watts, PhD, Director of Emergency Medicine Preclinical Research
Michael A. Puskarich, MD, Research Fellow
Michael A. Gellar, BS, Senior Research Technician
Mary-Beth Fulkerson, MS, Research Technician II
Contact Information: Jeffrey A. Kline, MD; John A. Watts, PhD