Carolinas HealthCare System

Clinical Research at Sanger

Sanger Heart & Vascular Institute is committed to progressive and leading edge medical research through a number of clinical trials.

Highlights from Clinical Research 2011 (SHVI)

  • Continued enrollment in a large number of clinical trials with more than 2000 patients enrolled in 45 ongoing trials
  • SHVI physicians generated more than 150 publications, abstracts and presentations in 2011
  • Gained national exposure as thought leaders through attendance at national conferences with presentations on research effort
  • Streamlined research efforts by integrating independent research programs at CMC and CMC-NE into one overarching program for the metro Charlotte area, ultimately leveraging the size and scope of laboratory
  • Added depth and breadth to the research program with the onboarding of Charles Bridges, MD, Sc.D. and Frank Arko, MD. Dr. Bridges is a national leader in the field of gene therapy for cardiac regeneration in heart failure and Dr. Arko is nationally recognized in the field of thoracic endograft therapy, serving as the national PI on several clinical trials.

Featured studies in 2011 (SHVI):

  • SHVI faculty participated in highly selective trials to bring new technology and services to CHS, showcasing our level of expertise and bringing an awareness of SHVI as a nationally-recognized institution
  • Trials include percutaneous mitral valve repair, thoracic stent grafting for traumatic rupture, atrial appendage occlusion for stroke prevention, implantable internal heart monitors for the remote management of heart failure, and pediatric LVADS for companionate use.
  • Also selected as sites for new technologies including renal nerve ablation for treatment of uncontrollable blood pressure, stem cell therapy for treatment of chest pain, and research to look at completely bio absorbable stents.
  • More than 1,200 patients enrolled in the ADAPT DES registry making SHVI the second highest enrolling site in the United States. Dr. Rinaldi served as a national co-PI and Dickson Advanced Analytics (DA2) (formerly The Dickson Institute) served as the data coordination and analysis center, managing data for more than 8,000 enrollees. This project brought more than $6.4 million to CHS for coordination and management of the project and database.
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