Charles Vannoy, PhDCharles Vannoy, PhD
Postdoctoral Research Fellow
McColl-Lockwood Laboratory for Muscular Dystrophy Research
Department of Neurology
Carolinas HealthCare System

Prior Positions and Experience

2010-2012 Postdoctoral Research Fellow, Department of Chemical and Physical Sciences, University of Toronto, Mississauga, ON, Canada
2007-2010 Graduate Research Associate, Department of Chemistry, University of Miami, Coral Gables, FL

Education

PhD:          2010, University of Miami (Coral Gables, FL)
BS & BA:   2006, Southern Methodist University (Dallas, TX)

Research Interest

My research is devoted to the development of genetic therapies for muscular dystrophy, specifically limb-girdle muscular dystrophy (LGMD). Gene therapy is able to provide a normal copy of the defected gene to the diseased muscles, which can effectively rescue the muscles or ameliorate the disease without any additional pharmacological intervention. The main focus of the proposed research is to investigate the use of adeno-associated virus (AAV) mediated gene delivery systems to achieve therapeutic effects in transgenic mice engineered to display phenotypic abnormalities (i.e., skeletal muscle wasting and cardiac problems) encountered in human disease. AAV vectors are replication-defective, nonenveloped viruses that have been successfully used to establish efficient and long-term gene expression in a variety of tissues, including muscle, without significant immune response or toxicity. AAV vectors can readily bypass extracellular barriers because of their small viral particle size (20 nm), which facilitates efficient transduction of muscle myofibers of various levels of maturity. With these optimized technologies, we hope to transition site-specific gene therapies for muscular dystrophy into the clinical setting.

Publications

Vannoy CH, Xu L, Keramaris E, Lu P, Xiao X, Lu QL. Adeno-associated virus-mediated overexpression of LARGE rescues α-dystroglycan function in dystrophic mice with mutations in the fukutin-related protein. Hum Gene Ther Methods. 2014;25(3):187-96. PMID: 24635668

Tavares AJ, Noor MO, Uddayasankar U, Krull UJ, Vannoy CH. Solid-phase supports for the in situ assembly of quantum dot-FRET hybridization assays in channel microfluidics. Methods Mol Biol. 2014;1199:241-55. PMID: 25103813

Vannoy CH, Chong L, Le C, Krull UJ. (2013). A Competitive Displacement Assay with Quantum Dots as Fluorescence Resonance Energy Transfer Donors. Anal Chim Acta. 2013;759:92-9. PMID: 23260681

Chong L, Vannoy CH, Noor MO, Krull UJ. (2012). Intracellular Nucleic Acid Interactions Facilitated by Quantum Dots: Conceptualizing Theranostics. Ther Deliv. 2012;3(4):479-99. PMID: 22834078

Tavares AJ, Noor MO, Vannoy CH, Algar WR, Krull UJ. (2012). On-Chip Transduction of Nucleic Acid Hybridization Using Spatial Profiles of Immobilized Quantum Dots and Fluorescence Resonance Energy Transfer. Anal Chem. 2012;84(1):312-9. PMID: 22136151

Vannoy CH, Tavares AJ, Noor MO, Uddayasankar U, Krull UJ. (2011). Biosensing with Quantum Dots: A Microfluidic Approach. Sensors. 2011;11(10):9732-63. PMCID: PMC3231262

Vannoy CH, Leblanc RM. (2010). Effects of DHLA-Capped CdSe/ZnS Quantum Dots on the Fibrillation of Human Serum Albumin. J Phys Chem B. 2010;114(33), 10881-8. PMID: 20681557

Vannoy CH, Xu J, Leblanc RM. (2010). Bioimaging and Self-Assembly of Lysozyme Fibrils Utilizing CdSe/ZnS Quantum Dots. J Phys Chem C. 2010;114(2):766-73. See article

Grant Support

Grant Title: Exploration of mini-agrin as a therapeutic for treatment of FKRP deficient dystroglycanopathies
Funding Agency: LGMD2I Research Fund
Role: Postdoctoral Research Fellow
Year: 2013

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