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CSF analysis

Definition

Cerebrospinal fluid (CSF) analysis is a group of laboratory tests that measure proteins, sugar (glucose), and other chemicals in the fluid that surrounds and protects the brain and spinal cord.

Alternative Names

Cerebrospinal fluid analysis

How the test is performed

A sample of CSF is needed. A lumbar puncture, also called a spinal tap, is the most common way to collect this sample. For information on this procedure, see lumbar puncture. Other methods for collecting CSF are rarely used, but may be recommended in some cases. See also:

After the sample is taken, it is sent to the laboratory for evaluation.

How to prepare for the test

See: Lumbar puncture

How the test will feel

See: Lumbar puncture

Why the test is performed

Analysis of CSF can help detect certain conditions and diseases. All of the following can be, but are not always, measured in a sample of CSF:

Normal Values

  • Antibodies and DNA of common viruses: None
  • Bacteria: No bacteria grows in a lab culture
  • Cancerous cells: No cancerous cells present
  • Cell count: less than 5 white blood cells (all mononuclear) and 0 red blood cells
  • Chloride: 110 to 125 mEq/L
  • Fungus: None
  • Glucose: 50 to 80 mg/dL(or greater than two-thirds of blood sugar level)
  • Glutamine: 6 to 15 mg/dL
  • Lactate dehydrogenase: less than 2.0 to 7.2 U/mL
  • Oligoclonal bands: 0 or 1 bands that are not present in a matched serum sample
  • Protein: 15 to 60 mg/dL

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.

Note: mg/dL = milligrams per deciliter

What abnormal results mean

An abnormal CSF analysis result may be due to many different causes, including:

What the risks are

For information regarding risks of a spinal tap, see: Lumbar puncture

References

Griggs RC, Jozefowicz RF, Aminoff MJ. Approach to the patient with neurologic disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 418.

Rosenberg GA. Brain edema and disorders of cerebrospinal fluid circulation. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J, eds. Bradley: Neurology in Clinical Practice. 5th ed. Philadelphia, Pa: Butterworth-Heinemann Elsevier; 2008:chap 63.


Review Date: 4/30/2011
Reviewed By: Kevin Sheth, MD, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine;David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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