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Megaloblastic anemia

Definition

Megaloblastic anemia is a blood disorder in which there is anemia with larger-than-normal red blood cells.

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues.

Alternative Names

Anemia - megaloblastic

Causes, incidence, and risk factors

Megaloblastic anemia is usually caused by a deficiency of folic acid or vitamin B12.

Other less common causes are:

Risk factors relate to the causes.

See also:

Symptoms

See:

Signs and tests

For testing information, see:

Treatment

The first goal is to diagnose the cause of the anemia. The treatment depends on the cause. Anemias related to specific vitamin deficiencies are discussed separately.

See:

References

Antony AC. Megoblastic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 39.

Kaferie J, Strzoda CE. Evaluation of macrocytosis. Am Fam Physician. 2009;79:203-208.


Review Date: 5/9/2011
Reviewed By: A.D.A.M. Editorial Team: David Zieve, MD, MHA, and David R. Eltz. Previously reviewed by Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital (1/31/2010).
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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