Lupus anticoagulants Definition
Lupus anticoagulants are antibodies against substances in the lining of cells that prevent blood clotting in a test tube. These substances are called phospholipids.
Persons with these antibodies may have an abnormally high risk of blood clotting.
Causes, incidence, and risk factors
Lupus anticoagulants are usually found in persons with autoimmune diseases, such as
systemic lupus erythematosus (SLE).
They may also be found in persons who take certain medications, including phenothiazines, phenytoin, hydralazine, quinine, and the antibiotic amoxicillin.
Persons with inflammatory bowel disease (
Crohn's disease and ulcerative colitis), infections, and certain tumors may have lupus anticoagulants.
Some people have no risk factors for this condition. In some cases, SLE is linked to an increased risk of
blood clots and may be the cause of recurrent miscarriages.
You may not have any symptoms. Symptoms that may occur include:
Recurrent miscarriages Signs and tests
The following tests may be done:
No treatment is required if you do not have symptoms.
If you develop blood clots, your doctor may prescribe blood thinners (heparin followed by warfarin). Higher-than-usual doses of warfarin may be needed.
The outcome is usually good with appropriate therapy. Some patients have difficult-to-control clots with recurrent symptoms.
Complications Calling your health care provider
Call your health care provider if you notice symptoms of a blood clot, which include swelling or redness in the leg, shortness of breath, or pain, numbness and pallor in an arm or leg.
Awareness of risk factors may allow early diagnosis. Prevention may not be possible.
Harris ED, Budd RC, Genovese MC, Firestein GS, Sargent JS, Sledge CB.
Kelley's Textbook of Rheumatology. 7th ed. St. Louis, Mo: WB Saunders; 2005.
Todd Gersten, M.D., Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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