Carolinas HealthCare System

Research and Clinical Trials

Other Hematopoietic 

Brief Description PrincipalĀ Investigator
Complete response of VOD [ Time Frame: D+100 from SCT or 100 days from start of chemotherapy] Gilman, Andrew 
To determine the ability of CD34+ cell selection using the CliniMACSĀ® device as the sole
GVHD prophylaxis to prevent severe (grade III-IV) acute GVHD in recipients of
alternative donor (mismatched related donor and unrelated donor) hematopoietic stem
cell transplants.
Gilman, Andrew 
To assess the ability of a donor lymphocyte infusion given with methotrexate
GVHD prophylaxis to accelerate immune recovery following transplantation of a
CD34+selected, T cell-depleted stem cell product.
Gilman, Andrew 
Primary:
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Exploratory:
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda 
The objective of this treatment protocol is to allow pediatric patients who have failed to respond to steroid treatment for acute GVHD expanded access to Prochymal. Gilman, Andrew 
The purpose of this study is to determine if treatment with alemtuzumab, fludarabine and melphalan followed by related/unrelated bone marrow, peripheral blood stem cell, or umbilical cord blood cell transplant will result in donor engraftment on day +100. It is also to determine major toxicities from this conditioning regimen, within the first 100 days after transplantation. Gilman, Andrew 
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