Carolinas HealthCare System

Research and Clinical Trials

Brain and Nervous System 

Brief Description PrincipalĀ Investigator
To determine if nivolumab monotherapy improves overall survival (OS), as compared with bevacizumab in recurrent glioblastoma multiforme subjects treated with first line treatment with radiotherapy and temozolomide. Sumrall, Ashley 
The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Kaplan, Joel 
This randomized phase III trial is studying different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma or supratentorial primitive neuroectodermal tumor. Kaplan, Joel 
This randomized phase II trial is studying how well giving temozolomide and irinotecan hydrochloride together with or without bevacizumab works in treating young patients with recurrent or refractory medulloblastoma or CNS primitive neuroectodermal tumors. Kaplan, Joel 
This randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patients with newly diagnosed ependymoma. Kaplan, Joel 
This randomized phase II/III trial is studying how well image-guided radiosurgery or stereotactic body radiation therapy works and compares it to external-beam radiation therapy in treating patients with localized spine metastasis. Sharp, Hadley 
This trial studies the natural history of brain function, quality of life, and seizure control in patients with brain tumor who have undergone surgery. Sumrall, Ashley 
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