Carolinas HealthCare System

Research and Clinical Trials

Brain and Nervous System 

Brief Description PrincipalĀ Investigator
To determine if nivolumab monotherapy improves overall survival (OS), as compared with bevacizumab in recurrent glioblastoma multiforme subjects treated with first line treatment with radiotherapy and temozolomide. Sumrall, Ashley Love 
The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Kaplan, Joel Adam 
This randomized phase II trial is studying how well giving temozolomide and irinotecan hydrochloride together with or without bevacizumab works in treating young patients with recurrent or refractory medulloblastoma or CNS primitive neuroectodermal tumors. Kaplan, Joel Adam 
This randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patients with newly diagnosed ependymoma. Kaplan, Joel Adam 
Primary Objective
The primary objective of this phase II study is to assess the efficacy of a treatment regimen that involves the administration of temozolomide and bevacizumab with concurrent use of the medical device, NovoTTF?-100A System, by evaluating the percentage of newly diagnosed unresectable glioblastoma (GBM) patients who are alive at 12 months.

Secondary Objective
- Evaluate progression free survival (PFS)
- Evaluate overall response rate (ORR) and disease control rate (DCR)
Sumrall, Ashley Love 
This randomized phase II/III trial is studying how well image-guided radiosurgery or stereotactic body radiation therapy works and compares it to external-beam radiation therapy in treating patients with localized spine metastasis. Sharp, Hadley Jean 
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