Transposition of the great vessels is a heart defect that occurs from birth (congenital). The two major vessels that carry blood away from the heart -- the aorta and the pulmonary artery -- are switched (transposed).
Transposition of the great arteries; TGA; d-TGA
Causes, incidence, and risk factors
The cause of most congenital heart defects is unknown.
Factors in the mother that may increase the risk of this condition include:
Age over 40
Poor nutrition during pregnancy (prenatal nutrition)
Rubella or other viral illness during pregnancy
Transposition of the great vessels is a cyanotic heart defect. This means there is decreased oxygen in the blood that is pumped from the heart to the rest of the body.
In normal hearts, blood that returns from the body goes through the right side of the heart and pulmonary artery to the lungs to get oxygen. The blood then comes back to the left side of the heart and travels out the aorta to the body.
In transposition of the great vessels, the blood goes to the lungs, picks up oxygen, returns to the heart, and then flows right back to the lungs without ever going to the body. Blood from the body returns to the heart and goes back to the body without ever picking up oxygen in the lungs.
Symptoms appear at birth or very soon afterward. How bad the symptoms are depends on the type and size of heart defects (such as atrial septal defect or patent ductus arteriosus) and how much oxygen moves through the body's general blood flow.
The condition is the second most common cyanotic heart defect.
Blueness of the skin
Clubbing of the fingers or toes
Shortness of breath
Signs and tests
The health care provider may detect a heart murmur while listening to the chest with a stethoscope. The baby's mouth and skin will be a blue color.
Tests often include the following:
Echocardiogram (if done before birth, it is called a fetal echocardiogram)
Pulse oximetry (to check blood oxygen level)
The baby will immediately receive a medicine called prostaglandin through an IV (intravenous line). This medicine helps keep a blood vessel called the the ductus arteriosus open, allowing some mixing of the two blood circulations.
A procedure using a long, thin flexible tube (balloon atrial septostomy) may be needed to create a large hole in the atrial septum to allow blood to mix.
A surgery called an arterial switch procedure is used to permanently correct the problem within the baby's first week of life. This surgery switches the great arteries back to the normal position and keeps the coronary arteries attached to the aorta.
The child's symptoms will improve after surgery to correct the defect. Most infants who undergo arterial switch do not have symptoms after surgery and live normal lives. If corrective surgery is not performed, the life expectancy is only months.
Coronary artery problems
Heart valve problems
Irregular heart rhythms (arrhythmias)
Calling your health care provider
This condition can be diagnosed before birth using a fetal echocardiogram. If not, it is usually diagnosed soon after a baby is born.
Go to the emergency room or call the local emergency number (such as 911) if your baby's skin develops a bluish color, especially in the face or trunk.
Call your health care provider if your baby has this condition and new symptoms develop, get worse, or continue after treatment.
Women who plan to become pregnant should be immunized against rubella if they are not already immune. Eating well, avoiding alcohol, and controlling diabetes both before and during pregnancy may be helpful.
Webb GD, Smallhorn JF, Therrien J, Redington AN. Congenital heart disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 9th ed. Philadelphia, Pa:Saunders Elsevier; 2011:chap 65.
Kurt R. Schumacher, MD, Pediatric Cardiology, University of Michigan Congenital Heart Center, Ann Arbor, MI. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.