Chinese restaurant syndrome is a collection of symptoms that some people experience after eating Chinese food. A food additive called monosodium glutamate (MSG) has been implicated, but it has not been proved to be the substance that causes this condition.
Hot dog headache; Glutamate-induced asthma; MSG (monosodium glutamate) syndrome
Causes, incidence, and risk factors
In 1968, reports of a series of serious reactions to Chinese food were first described. MSG was felt to be the cause of these symptoms. Since then, many studies have failed to show a connection between MSG and the symptoms that some people describe after eating Chinese food.
For this reason, MSG continues to be used in some meals. However, it is possible that some people are particularly sensitive to food additives, and MSG is chemically similar to one of the brain's most important chemicals, glutamate.
Treatment depends on the symptoms. Most, such as headache or flushing, need no treatment.
Life-threatening symptoms require immediate medical attention. They may be similar to any other severe allergic reaction and include:
Shortness of breath
Swelling of the throat
Most people recover from mild cases of Chinese restaurant syndrome without treatment and with no lasting problems.
People who have experienced life-threatening reactions need to be extremely cautious about what they eat and should always carry medication prescribed by their doctor for emergency treatment.
Calling your health care provider
If you experience any symptoms such as shortness of breath, heart palpitations, chest pain, or swelling of the lips or throat, go to the nearest emergency room immediately.
Bush RK, Taylor SL. Adverse reactions to food and drug additives. In: Adkinson NF Jr, ed. Middleton’s Allergy: Principles and Practice. 7th ed. Philadelphia, Pa: Mosby Elsevier; 2008:chap 66.
Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.