Carolinas HealthCare System

Complementary and Alternative Medicine - Supplement Interaction

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Possible Interactions with: Eicosapentaenoic Acid (EPA)

Also listed as: Eicosapentaenoic Acid (EPA); EPA


In combination with aspirin, omega-3 fatty acids could help treat coronary artery disease. Consult your health care provider about whether this combination would be appropriate for you if you have coronary artery disease.

Omega-3 fatty acids may reduce some of the side effects associated with cyclosporine therapy, which is often used to lower the chances of rejection in transplant recipients. Consult your health care provider before adding any new herbs or supplements to your existing medication regimen.

In an animal study, omega-3 fatty acids protected the stomach against ulcers induced by reserpine and nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin. Consult your health care provider before using omega-3 fatty acids if you are currently taking these medications.

EPA has also been shown to boost the effects of a combination of low-dose etretinate and a topical corticosteroid medication used to treat severe, chronic psoriasis. Consult your health care provider to determine if this combination therapy may be of benefit for you if you suffer from chronic psoriasis.

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