Treatment depends on the cause of the problem. Avoiding medications that lead to this condition may relieve symptoms quickly.
Limiting salt and fluid in the diet can improve swelling and high blood pressure. Limiting protein in the diet can help control the buildup of waste products in the blood (azotemia) that can lead to symptoms of acute kidney failure.
If dialysis is necessary, it usually is required for only a short time.
Corticosteroids or stronger anti-inflammatory medications such as cyclophosphamide can sometimes be helpful.
Most often, interstitial nephritis is a short-term disorder. In rare cases, it can cause permanent damage, including chronic kidney failure.
Acute interstitial nephritis may be more severe and more likely to lead to long-term or permanent kidney damage in elderly people.
Remuzzi G, Perico N, DeBroe ME. Tubulointerstitial diseases. In: Brenner BM, ed. Brenner and Rector's the Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 33.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Herbert Y. Lin, MD, PHD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.