In hypopituitarism, there is a lack of one or more pituitary hormones. Lack of the hormone leads to loss of function in the gland or organ that it controls. For example, no TSH leads to loss of function in the thyroid gland.
Levels of a pituitary hormone may be high in the bloodstream if you have a pituitary tumor that is producing too much of that hormone. The tumor may crush other cells of the pituitary, leading to low levels of other hormones.
If hypopituitarism is caused by a tumor, you may need surgery to remove the tumor, with or without radiation therapy.
You will need lifelong hormone therapy to replace hormones that are no longer made by organs under the control of the pituitary gland. These may include:
Drugs are also available to treat related infertility in men and women.
Hypopituitarism is usually permanent and requires lifelong treatment. However, you can expect a normal life span.
Side effects of drug therapy can develop. In severe illness, failing to take extra corticosteroids can be life-threatening.
Calling your health care provider
Call your health care provider if you develop symptoms of hypopituitarism.
In most cases, the disorder is not preventable. Awareness of risk may allow early diagnosis and treatment.
Melmed S, Kleinberg D, Ho K. Pituitary physiology and diagnostic evaluation. In: Kronenberg H, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 8.
Nancy J. Rennert, MD, Chief of Endocrinology & Diabetes, Norwalk Hospital, Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.