Carolinas HealthCare System

Research and Clinical Trials

Soft Tissue 

Brief Description PrincipalĀ Investigator
Describe the sensitivity of flow cytometry to detect tumor cells in the
blood and bone marrow of Ewing sarcoma patients, using FISH as a goldstandard comparison to confirm the presence of tumor cells.
Oesterheld, Javier E 
The purpose of this study is to collect and store tumor tissue, blood, and bone marrow samples from patients with soft tissue sarcoma that will be tested in the laboratory. Kaplan, Joel Adam 
COG ANBL0032: Phase III Randomized Study of Chimeric antibody 14.18 (Ch 14.18) in High Risk Neurobl Kaplan, Joel Adam 
The purpose of this study is to evaluate the factors currently used for risk-group assignment (DNA content, MYCN copy number, and tumor histology) in patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Kaplan, Joel Adam 
The first part of the study will determine the feasibility of adding pazopanib in combination with radiation or chemoradiation in pediatric and adult patients newly diagnosed with unresected intermediate- and high-risk (Non-Rhabdomyosarcoma Soft Tissue Sarcomas) NRSTS.

The second part of the study will compare the rates of response of (1) preoperative pazopanib plus chemoradiation versus preoperative chemoradiation alone for potentially resectable > 5 cm, Grade 3 intermediate to high risk ch
Kaplan, Joel Adam 
The primary objective of this study is to determine the efficacy of administration of aldoxorubicin compared to investigator's choice of treatment in subjects with metastatic, locally advanced, or unresectable soft tissue sarcomas who have relapsed or were refractory to prior non-adjuvant chemotherapy, as measured by progression-free survival (PFS). Livingston, Michael Balfour 
To evaluate the preventative activity of DFMO as a single agent in patients that are in remission based on: Event Free Survival (EFS). Oesterheld, Javier E 
To compare the progression-free survival (PFS) of eligible subjects treated with regorafenib or placebo according to modified RECIST version 1.1. Livingston, Michael Balfour 
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