Carolinas HealthCare System

Research and Clinical Trials

Multiple Myeloma 

Brief Description PrincipalĀ Investigator
Estimate the progression-free survival (PFS) of patients treated with carfilzomib + ARRY-520 and of patients treated with single-agent carfilomib. Usmani, Saad 
The primary objective is to determine the efficacy of 2 treatment regimens of daratumumab in subjects with multiple myeloma who have received at least 3 prior lines of therapy or are double refractory to a Proteasome Inhibitor and an IMiD. Usmani, Saad 
Primary:
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Exploratory:
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda 
Phase I: to determine the maximum tolerated doses (MTD) and the recommended Phase 2 dose (RP2D) of ibrutinib in combination with carfilzomib; and to describe the toxicities associated with the combination of ibrutinib and carfilzomib in subjects with relapsed or relapsed and refractory multiple myeloma (MM). Usmani, Saad 
Phase I: To determine appropriate Phase II dose of elotuzumab to use in combination with lenalidomide, bortezomib and dexamethasone for patients with multiple myeloma.
Phase II: To assess whether incorporation of the novel agent elotuzumab into the treatment algorithm of high risk multiple myeloma (HRMM) will improve progression-free survival (PFS). Also, to estimate the frequency and severity of toxicities of this treatment strategy in this patient population.
Usmani, Saad 
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