Carolinas HealthCare System

Research and Clinical Trials

Multiple Myeloma 

Brief Description PrincipalĀ Investigator
This multicenter Phase 2 study is designed to assess the efficacy and safety of ARRY-520 in approximately 160 patients with multiple myeloma who have received at least 2 prior lines of therapy; have received prior bortezomib and lenalidomide; and have disease refractory to carfilzomib and/or pomalidomide Usmani, Saad 
Estimate the progression-free survival (PFS) of patients treated with carfilzomib + ARRY-520 and of patients treated with single-agent carfilomib. Usmani, Saad 
To compare the efficacy of daratumumab when combined with
lenalidomide and dexamethasone (DRd) to that of lenalidomide and
dexamethasone (Rd), in terms of progression-free survival (PFS) in
subjects with relapsed or refractory multiple myeloma.
Usmani, Saad 
Primary:
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Exploratory:
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda Rene 
Phase 1b: To determine the maximum tolerated dose and identify the recommended Phase 3 dose of oprozomib in combination with pomalidomide and dexamethasone.
Phase 3: To compare progression-free survival between subjects treated with OPomD versus those treated with PomD.
Usmani, Saad 
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