Carolinas HealthCare System

Research and Clinical Trials


Brief Description PrincipalĀ Investigator
To investigate the safety and tolerability of AZD9291 when given orally to patients with locally advanced or metastatic Non Small Cell Lung Cancer (NSCLC) who have progressed following prior therapy with an Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) agent.

Secondary objectives include defining the maximum tolerated dose or maximum feasible dose of AZD9291; to investigate the safety and tolerability of AZD9291 when given orally as first line therapy to patients
Haggstrom, Daniel 
The purpose of this study is to evaluate the objective response rate (ORR) of nivolumab monotherapy or nivolumab combined with ipilimumab in subjects with advanced or metastatic tumors. Amin, Asim 
To evaluate progression free survival (PFS) with nab-paclitaxel as maintenance treatment after response or stable disease (SD) with nab-paclitaxel plus carboplatin in subjects with squamous cell NSCLC. Mileham, Kathryn 
The primary objective of this study is to evaluate the safety and tolerability of LY2835219 when administered orally in combination with multiple single-agent options to patients with Stage IV non-small cell lung cancer (NSCLC) using Common Terminology Criteria for Adverse Events (CTCAE version 4.0, NCI 2009). The secondary objectives of the study are to determine the pharmacokinetics (PK) of LY2835219 when given in combination with multiple single-agent options; to document the antitumor activ Kim, Edward 
The purpose of this specimen banking study is to determine the positive predictive value (PPV) and negative predictive value (NPV) of the multi-protein classifier based on the observed prevalence of Non-Small Cell Lung Cancer, for patients with a lung nodule between 8 mm to 20 mm in size, except for those characterized as "pure ground glass opacity" or "non-solid." Mileham, Kathryn 
To compare the overall survival (OS) of previously treated patients with SCC NSCLC treated with MK-3475 compared to docetaxel. Carrizosa, Daniel 
To determine the maximum tolerated dose (MTD) of carfilzomib given in combination with standard dose carboplatin on Day 1 and etoposide on Days 1, 2, and 3 every 3 weeks as treatment for previously untreated extensive-stage small-cell lung cancer (ES-SCLC). Haggstrom, Daniel 
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