Carolinas HealthCare System

Research and Clinical Trials

Leukemia, not otherwise specified 

Brief Description Principal Investigator
Primary: To determine the safety, tolerability, DLT and combination maximum tolerated dose (combination MTD) of
urelumab in combination with rituximab in subjects with relapsed/refractory B-NHL (including FL and DLBCL) or
CLL.
Secondary Objectives:
1) To characterize the preliminary multidose PK profile of urelumab in combination with rituximab in subjects with
relapsed/refractory B-NHL (including FL and DLBCL) or CLL.
2) To characterize the immunogenicity of urelumab in combination with r
Ghosh, Nilanjan 
To compare EFS in patients with newly diagnosed T-ALL and T-LLy who are randomized to a modified ABFM backbone versus bortezomib plus the modified ABFM backbone.
The primary goal in this trial is to prevent relapse. AALL1231 will test two major strategies to meet this goal: (1) to modify the existing chemotherapy platform to mirror the most efficacious backbone that has been tested in Phase 3 trials; and, (2) to randomize patients to receive/not receive a novel agent (bortezomib), with strong b
Kaplan, Joel Adam 
To determine the ability of CD34+ cell selection using the CliniMACS® device as the sole
GVHD prophylaxis to prevent severe (grade III-IV) acute GVHD in recipients of
alternative donor (mismatched related donor and unrelated donor) hematopoietic stem
cell transplants.
Gilman, Andrew Lee 
Primary:
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Exploratory:
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda Rene 
Primary:
1.0 To obtain high quality and germline tissue from patients with myeloid hematologic malignancies in pre-malignant conditions. This material will be used for a variety of genetic analyses aimed at identification of novel mutations involved in the initiation and progression of these diseases.

Exploratory:
1.0 To sequence AML genomes for the discovery of mutations or germline variants.

2.0 To identify inherited genetic polymorphisms or mutations in germline DNA that increase susc
Avalos, Belinda Rene 
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