Carolinas HealthCare System

Research and Clinical Trials

HIV 

Brief Description Principal Investigator
The purpose of this study is to evaluate the experimental drug elvitegravir which is one of a new class of anti-HIV medications called integrase inhibitors. The study will attempt to determine if elvitegravir is safe and effective when given in combination with the background regimen (the other antiviral medications that a patient may currently be taking or will take to participate in the study), in subjects who are failing their current regimen of HIV medications. Johnson, Marc 
A study for HIV-1 infected individuals currently taking Complera® with an undectable viral load. Complera will be compared to an investigational fixed dose combination (FDC) tablet containing FTC/RPV/TAF. The trial is not only measuring the effectiveness of the medication to suppress viral load, but also comparing the side effects of the two medications. Patients will be asked to follow-up for at least one year. Fixed Dose Combination tablets help to decrease the pill burden for patients. Johnson, Marc 
HIV treatment experienced study looking at those on a current regimen containing EFV/FTC/TDF FDC (Atripla) to continue treatment, versus switching to FTC/RPV/TAF FDC. Polk, Christopher 
The purpose of this study is to determine if an investigational treatment regimen of BMS-663068 (BMS Attachment Inhibitor) twice a day, plus other antiretroviral medications used in combination is safe and effective for the treatment of subjects who are infected with Human Immunodeficiency Virus (HIV-1). HIV positive subjects in this research study must be "Heavily Treatment Experienced". This means you must have taken many HIV medications during the history of your disease. Johnson, Marc 
This trial is comparing a new single tablet combination medication (MK-1439A) to Atripla in HIV patients who are treatment naïve (never been on medications). Johnson, Marc 
This trial is comparing the safety and efficacy of a new single tablet regimen (MK1439A) to current PI boosted regimen in HIV infected adults that are suppressed on their medications. Johnson, Marc 
To determine the safety and efficacy of an experimental drug, abacavir/dolutegravir/lamivudine (ABC/DTG/3TC) fixed dose combination as a single tablet regimen compared with subjects taking their current combined antiretroviral therapy (cART) for the treatment of HIV-1 infected adults in whome the HIV-1 virus is currently suppressed. Johnson, Marc 
The purpose of this study is to determine the safety and efficacy of an experimental drug, abacavir/dolutegravir/lamivudine (ABC/DTG/3TC) fixed dose combination as a single tablet regimen compared with subjects taking their current combined antiretroviral therapy (cART) for the treatment of HIV-1 infected adults in whom the HIV-1 virus is currently suppressed Johnson, Marc 
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