Carolinas HealthCare System

Research and Clinical Trials

Breast - Female 

Brief Description PrincipalĀ Investigator
This phase II trial studies how well breast-conserving surgery and radiation therapy work in treating patients with multiple ipsilateral breast cancer White, Richard L 
Celera Corporation: Comparison of Breast Cancer Somatic Gene Expression Measurements for Potential O Calhoun, Ben 
The purpose of this study is to observe the cosmetic outcomes, patient satisfaction, and complications after skin sparing mastectomy with preservation of the nipple areolar complex. White, Richard L 
This trial is studying how well hormone therapy or chemotherapy before surgery based on gene expression analysis works in treating patients with breast cancer. Limentani, Steven A 
The purpose of this study is to determine whether the addition of daily BKM120 to fulvestrant is effective and safe in treating patients with hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer refractory to aromatase inhibitor.


Brick, Wendy 
The primary aim of this Phase III randomized clinical trial is to determine whether trastuzumab given concurrently with radiation therapy (RT) is more beneficial in preventing subsequent ipsilateral breast cancer recurrence, ipsilateral skin cancer recurrence, or ipsilateral DCIS, when compared with RT alone in women with HER2-positive ductal carcinoma in situ (DCIS) resected by lumpectomy.
Limentani, Steven A 
To determine whether the addition of trastuzumab to chemotherapy (TC or AC?_WP) improves invasive disease-free survival (IDFS) in women with resected node-positive or high-risk node-negative breast cancer which is reported as HER2-low by all HER2 testing performed. Limentani, Steven A 
NSABP B-50-I: A randomized, multicenter, open-label phase III study to evaluate the eff Limentani, Steven A 
The primary aim of the study is to determine the pathologic complete response (pCR) rate in breast and axillary nodes following the neoadjuvant therapy regimens. Limentani, Steven A 
The purpose of this study is to assess the safety and tolerability of iniparib administered as monotherapy or in combination regimens in patients previously treated with iniparib in a clinical study and who have derived clinical benefit after completion of the parental study's objectives. Limentani, Steven A 
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