Carolinas HealthCare System

Research and Clinical Trials

Myeloid and Monocytic Leukemia 

Brief Description PrincipalĀ Investigator
This phase II trial is studying donor stem cell transplant to see how well it works in treating young patients with acute myeloid leukemia with monosomy 7, -5/5q-, high FLT3-ITD AR, or refractory or relapsed acute myelogenous leukemia. Kaplan, Joel 
This randomized phase II/III trial is studying how well giving bortezomib and sorafenib tosylate together works in treating patients with newly diagnosed acute myeloid leukemia with or without mutations Kaplan, Joel 
This trial is studying caspofungin acetate to see how it works compared to fluconazole in preventing invasive fungal infections in patients with acute myeloid leukemia who are undergoing chemotherapy. Kaplan, Joel 
To determine the ability of CD34+ cell selection using the CliniMACSĀ® device as the sole
GVHD prophylaxis to prevent severe (grade III-IV) acute GVHD in recipients of
alternative donor (mismatched related donor and unrelated donor) hematopoietic stem
cell transplants.
Gilman, Andrew 
Primary:
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Exploratory:
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda 
To determine the maximal tolerated dose (MTD) and/or tolerable dose of escalating doses of clofarabine starting from 20mg/m2/day to 40mg/m2/day from Day 1 to Day 5 in combination with mitoxantrone 12mg/m2/day on Day 3-6 as reinduction therapy for children, adolescents and young adults with poor risk refractory/relapsed acute leukemia or high grade NHL. Oesterheld, Javier 
To evaluate the feasibility of using azacitidine (AZA) followed by fludarabine and high dose cytarabine in pediatric patients with relapsed or refractory AML or ALL. Oesterheld, Javier 
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