Carolinas HealthCare System

Research and Clinical Trials

Multiple Myeloma 

Brief Description PrincipalĀ Investigator
Estimate the progression-free survival (PFS) of patients treated with carfilzomib + ARRY-520 and of patients treated with single-agent carfilomib. Usmani, Saad 
The primary objective is to determine the efficacy of 2 treatment regimens of daratumumab in subjects with multiple myeloma who have received at least 3 prior lines of therapy or are double refractory to a Proteasome Inhibitor and an IMiD. Usmani, Saad 
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda 
Phase I: to determine the maximum tolerated doses (MTD) and the recommended Phase 2 dose (RP2D) of ibrutinib in combination with carfilzomib; and to describe the toxicities associated with the combination of ibrutinib and carfilzomib in subjects with relapsed or relapsed and refractory multiple myeloma (MM). Usmani, Saad 
Phase I: To determine appropriate Phase II dose of elotuzumab to use in combination with lenalidomide, bortezomib and dexamethasone for patients with multiple myeloma.
Phase II: To assess whether incorporation of the novel agent elotuzumab into the treatment algorithm of high risk multiple myeloma (HRMM) will improve progression-free survival (PFS). Also, to estimate the frequency and severity of toxicities of this treatment strategy in this patient population.
Usmani, Saad 
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