Carolinas HealthCare System

Research and Clinical Trials

Multiple Myeloma 

Brief Description PrincipalĀ Investigator
This multicenter Phase 2 study is designed to assess the efficacy and safety of ARRY-520 in approximately 160 patients with multiple myeloma who have received at least 2 prior lines of therapy; have received prior bortezomib and lenalidomide; and have disease refractory to carfilzomib and/or pomalidomide Usmani, Saad Zafar 
Estimate the progression-free survival (PFS) of patients treated with carfilzomib + ARRY-520 and of patients treated with single-agent carfilomib. Usmani, Saad Zafar 
The purpose of this study is to compare the effectiveness of CMX001 to placebo for the prevention of CMV infection in stem cell transplant patients who do not have CMV before starting treatment with CMX001.

Shahid, Zainab 
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda Rene 
Phase 1b: To determine the maximum tolerated dose and identify the recommended Phase 3 dose of oprozomib in combination with pomalidomide and dexamethasone.
Phase 3: To compare progression-free survival between subjects treated with OPomD versus those treated with PomD.
Usmani, Saad Zafar 
Phase I: To determine appropriate Phase II dose of elotuzumab to use in combination with lenalidomide, bortezomib and dexamethasone for patients with multiple myeloma.
Phase II: To assess whether incorporation of the novel agent elotuzumab into the treatment algorithm of high risk multiple myeloma (HRMM) will improve progression-free survival (PFS). Also, to estimate the frequency and severity of toxicities of this treatment strategy in this patient population.
Usmani, Saad Zafar 
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