Carolinas HealthCare System

Research and Clinical Trials


Brief Description PrincipalĀ Investigator
To compare overall survival (OS) between study arms in subjects treated with AGS-003 in combination with standard treatment (combination arm) versus active control of standard treatment alone (control arm) Amin, Asim 
The purpose is to determine the safety, effectiveness and best dose to use when giving Nivolumab in combination with Sunitinib, Pazopanib, or Ipilimumab for the treatment of metastatic renal cell carcinoma. Amin, Asim 
The purpose of this study is to classify patients with renal tumors by histological categorization, surgicopathological stage, presence of metastases, age at diagnosis, tumor weight and loss of heterozygosity for chromosomes 1p and 16q, to thereby define eligibility for a series of therapeutic studies. Kaplan, Joel 
This phase III clinical trial is studying how well combination chemotherapy and surgery work in treating young patients with Wilms tumor. Kaplan, Joel 
To determine if DASL subclassification can identify a group of patients with advanced
melanoma who are significantly more likely to respond to high dose IL-2-based therapy
(Class 2) than the historical 16% response rate in an unselected patient population.
Amin, Asim 
The purpose of this registry is to collect information on patients who are receiving treatment with Proleukin in an organized way, and to learn more about patient care during and after treatment. Amin, Asim 
Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor. This phase III trial is studying everolimus to see how well it works in treating patients with kidney cancer who have undergone surgery. Amin, Asim 
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