Carolinas HealthCare System

Research and Clinical Trials

Hodgkin's Lymphoma 

Brief Description PrincipalĀ Investigator
The purpose of this study is to establish a biologic specimen repository (of tumor tissue, tissue arrays, lymphoblastoid cell lines, host DNA, tumor and host RNA, serum, and plasma) and database linked to clinical features and outcomes from well-characterized cohorts of children and young adults with Hodgkin's lymphoma. Kaplan, Joel Adam 
To evaluate the feasibility of ABVD followed by brentuximab vedotin
consolidation in patients with previously untreated stage I or II non-bulky HL
based on the percentage of patients who achieve complete response (CR) by PET
post treatment.
Ghosh, Nilanjan 
Primary:
To collect high quality specimens from patients with hematologic disorders and normal volunteers.
Exploratory:
Future specimen analyses will be performed to determine the differences between sick and normal cells. Data used for these comparisons will include, but are not limited to: gene expression data, DNA, RNA, epigenetics, proteomics, metabolomics, and pathway analysys.
Avalos, Belinda Rene 
This open-label, randomized, 2-arm, multicenter, phase 3 study has the primary objective of comparing the modified progression-free survival (mPFS) obtained with brentuximab vedotin (ADCETRISĀ®) plus AVD (doxorubicin [Adriamycin], vinblastine, and dacarbazine; abbreviated A+AVD) versus that obtained with ABVD (doxorubicin [Adriamycin],bleomycin, vinblastine, and dacarbazine) for the frontline treatment of advanced classical Hodgkin lymphoma(HL)


Ghosh, Nilanjan 
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