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ACCORD-MIND Sub Study

What is the ACCORD-MIND Sub Study?

ACCORD-MIND is a research sub study to determine whether or not intensive therapy or control of blood glucose will reduce or increase the risk for impairment in memory and daily functioning compared to standard. Some persons with diabetes are more likely to develop difficulty remembering how to do things like manage their money, prepare meals, or monitor their diabetes. The ACCORD-MIND Sub Study will involve a group of 2,800 people with diabetes already participating in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study. This program is sponsored by the National Institute on Aging and the National Heart, Lung and Blood Institute in collaboration with participating healthcare providers. This ACCORD-MIND is a sub study to ACCORD and you do not have to volunteer for ACCORD-MIND to stay in ACCORD.

What is the purpose of ACCORD-MIND?

The goal of this study is to investigate the relationship between diabetes, treatment intensity, and thinking and memory in older patients. We also hope to find out why some individuals with Type 2 diabetes develop difficulties in managing their diabetes treatment regimen. Your participation in ACCORD-MIND will help doctors better understand and prevent declines in thinking and memory associated with diabetes.

The MIND MRI Study

It is known that some people with diabetes exhibit difficulty with thinking and memory. Magnetic Resonance Imaging (MRI) provides a picture of the brain that may identify changes that explain declines in mental function. Only about 650 people in ACCORD-MIND will receive an MRI and you do not have to have an MRI to volunteer. The MRI results will be used to understand the effects of various treatments for diabetes on the brain.

Who can participate?

Men and women 55 years or older who are already participating in the ACCORD Study are eligible for ACCORD-MIND.

What is involved in participation?

  1. You will have 30 minutes of memory testing every two years.
  2. In addition, you will need to identify a person to serve as a contact for you in case you develop difficulty with your memory. Ideally, the contact should have frequent interaction with you in order to provide information about your health.
  3. You will receive a brain MRI at the beginning of ACCORD-MIND and again in four years.

What are the benefits of participating?

  1. In addition to your regular medical care, the information given by you at each visit will be looked at by other doctors working on this program.
  2. All services related to this study are provided to you at no cost.
  3. This is a chance for you to join in a research effort which could help people like you who are at a greater risk for declines in thinking and memory and daily function. You will be contributing to medical knowledge regarding the possible usefulness of an intensive diabetes treatment program for preventing memory loss and functional decline.
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